HIV-1 latency
HIV 1 latency in actively dividing human T cell lines
... integrated HIV-rtTA provirus is prohibited by silencing/latency of the HIV LTR promoter we tried to activate the provirus in these ...preventing HIV-1 latency ...and ...
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Identification of novel genes associated with HIV-1 latency by analysis of histone modifications
... of latency in the early stages of ...repress HIV-1 replication and delay the pro- gression of AIDS, HIV-1 reemerges rapidly after an interruption in treatment [2, ...of ...
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Cellular and molecular mechanisms involved in the establishment of HIV 1 latency
... of HIV-1 latency and the pathways leading to viral reactivation, less is known about the establishment of latent ...how HIV-1 latency is established at the cellular and molecular ...
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Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV 1 Latency
... of HIV-1 latency in Th17 cells slightly reduces the yield of latent proviruses and highly sensitizes them to exogenous stimulators such as IL-15, ConA, or TCR ...on HIV-1 as it ...
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Gene silencing in HIV 1 latency by polycomb repressive group
... complex 1 (PRC1) and 2 (PRC2) ...HSV-1 latency [32]. To elucidate the HIV-1 latency related to H3K27me3 in more detail, we examined the expression levels of EED, BMI1 and RING2 ...
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Ex vivo analysis identifies effective HIV 1 latency–reversing drug combinations
... cell-associated HIV-1 RNA and virion release described here may represent increases in the magnitude of HIV-1 gene expression by a fixed number of cells, increases in the num- ber of cells ...
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Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins
... to HIV-1 LTR. The CTIP-2 and LSD-1 complex then synergistically downregulate the HIV-1 replication and transcription by modulating the epigenetic status of H3K9 in microglial cells, the ...
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The Viral Protein Tat Can Inhibit the Establishment of HIV-1 Latency
... of HIV-1 latency can best be appreciated in the results of ...in latency levels was observed for wt tat virus infections by day 56 ...of latency, since in the latter case, silencing has ...
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HIV 1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells
... of HIV-1 latency rely heavily on in vitro models, with several promi- nent systems utilizing direct infection of resting T cells (reviewed in ...unintegrated HIV-1 DNA, especially when ...
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Epigenetic Regulation of HIV-1 Latency in Astrocytes
... (class 1 and class II HDAC inhibitor), and trichostatin A (TSA) (an HDAC inhibitor) all po- tently induced HIV promoter activity ...of HIV LTR promoter activity was lower (5- to 14-fold) than that of ...
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Direct and Quantitative Single-Cell Analysis of Human Immunodeficiency Virus Type 1 Reactivation from Latency
... type 1 (HIV-1) to establish latent infections in cells has received renewed attention owing to the failure of highly active antiretroviral therapy to eradicate HIV-1 in ...of ...
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Epigenetic control of HIV-1 post integration latency: implications for therapy
... and HIV-1 latently infected primary CD4 + T cells ...of HIV-1 pro- virus methylation has been suggested in promoting la- tency as a late event of latency establishment and could be an ...
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Combination of Biological Screening in a Cellular Model of Viral Latency and Virtual Screening Identifies Novel Compounds That Reactivate HIV-1
... for HIV-1 la- tency in primary CD4 ⫹ T cells have been described (6, 9, 10, 51, FIG 6 MMQO enhances TCR/CD3 stimulation of HIV-1 reactivation from latency and prevents TCR-induced ...
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RNA induced epigenetic silencing inhibits HIV 1 reactivation from latency
... of HIV-1 latency that expresses GFP upon reactivation of full-length provirus [16], and Jurkat E6 cells were obtained through the NIH AIDS Rea- gent Program, Division of AIDS, NIAID, NIH: J-Lat ...
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Latency: the hidden HIV 1 challenge
... of HIV-1 transcription, the crucial molecular events that control maintenance of the quiescent state in resting T cells remain ...of latency in these cell lines is driven by selection of cells that ...
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Anti-HIV-1 ADCC Antibodies following Latency Reversal and Treatment Interruption
... type 1 (HIV-1) cure research is to develop agents and strategies that reactivate HIV-1 from latency, induce killing of the reactivated cells, and achieve HIV-1 ...
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A novel HIV 1 encoded microRNA enhances its viral replication by targeting the TATA box region
... targeting HIV-1 TATA box activate viral production from latently infected resting CD4 + T cells HIV-1 latency in resting primary CD4 + T cells is the major barrier for the eradication ...
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Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro
... modified HIV-1 strains — particularly those with the Nef gene deleted (32, 58, ...replication–competent HIV-1 viruses, X4 tropic NL4-3, and the R5 tropic J32228M4, as these recapitulate ...
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HIV 1 transcription and latency: an update
... in HIV-infected patients: one directed by ...next 1–2 years (reported in ...disrupts HIV-1 latency in blood resting CD4+ T ...exposure, HIV-1 RNA expression and chromatin ...
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Molecular control of HIV 1 postintegration latency: implications for the development of new therapeutic strategies
... of HIV-1 genes, but a marked activation of viral gene expression following treatment with cytokines or ...of HIV-1 latency, despite the fact that mutations in Tat (U1) [95] or in its ...
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