HIV-1 RT
MOLECULAR DOCKING STUDIES OF NOVEL IMIDAZOLE ANALOGS AS HIV 1 RT INHIBITORS
... of RT, where, acting as substrate decoys, they pre-terminate DNA chain elongation during viral DNA synthesis ...of HIV-1 RT (non-nucleoside inhibitor binding pocket), leading to a ...
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MOLECULAR DOCKING STUDIES AND ADME PREDICTION OF NOVEL ISATIN ANALOGS AS HIV 1 RT INHIBITORS WITH BROAD SPECTRUM CHEMO THERAPEUTIC PROPERTIES
... analogs 1-100 were docked into the active sites of different proteins ...of RT PDB code 1RT2, while compound 88, compound 13, and compound 38 showed highest docking score of ...namely HIV-1 ...
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The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance
... several HIV-1 proteins (Figure 2), facilitates quick mutation hotspot ...in HIV-1 RT structure, where mutated p51 could potentially cause varying (de)stabilization effects on p66, but ...
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Comparative Evaluation of Three Human Immunodeficiency Virus Genotyping Systems: the HIV GenotypR Method, the HIV PRT GeneChip Assay, and the HIV 1 RT Line Probe Assay
... of HIV type 1 (HIV-1). The HIV-GenotypR method (GenotypR; Specialty Laboratories, ...the HIV PRT GeneChip assay (GeneChip; Affymetrix, Santa Clara, ...the HIV-1 ...
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Drug-Resistant HIV-1 RT Gene Mutations in Patients under Treatment with Antiretroviral Drugs (HAART) in Iran
... of HIV standard genotyping among antiretroviral-naive individuals with unknown duration of ...Drug-resistant HIV-1 in Cuban children and their seropositive ...
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Virion Instability of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Mutated in the Protease Cleavage Site between RT p51 and the RT RNase H Domain
... g, 1 h at ...anti-HIV-1 RT (5 g/ml) or anti-HIV-1 p24 (5 g/ml) monoclonal antibodies or mouse anti-IN polyclonal serum (1:50) followed by incubation with secondary ...
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The mutation T477A in HIV 1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag Pol mutated in the p51 RNH cleavage site
... to 1 μg viral p24) at 175,000×g for ...anti-HIV-1 RT mAbs (6 μ g/mL), anti-HIV-1 IN (mixed 2C11 and 8G4, 1:40 dilution), anti-HIV-1 PR monospecific antiserum ...
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Comparison of Second-Strand Transfer Requirements and RNase H Cleavages Catalyzed by Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) and E478Q RT
... WT RT and E478Q RT polymerase-dependent and polymerase-independent RNase H ...for HIV-1 RT and E478Q RT are shown. (A to C) WT RT and E478Q RT are shown positioned ...
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Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
... active RT in virions led to hypersusceptibility of HIV-1 to azidothymidine (AZT), but not 2,3-dideoxy-3- thiacytidine (3TC), and that the results were likely due to the ability of RT to excise ...
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RT SHIV subpopulation dynamics in infected macaques during anti HIV therapy
... of HIV-1 subpopulations can be shaped by several selective forces, including host immune surveillance, ART, and competition between dif- ferent virus variants for host resources ...affecting ...
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VIRTUAL SCREENING OF NOVEL HIV RT NNRT INHIBITORS USING ZINC DATABASE
... inhibit HIV-1 reverse transcriptase (RT) by allosteric bind to change its ...with HIV-1 RT by binding to a single site on the p66 subunit of the p66/p51 heterodimeric enzyme, ...
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HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors
... and HIV-1 RT ...of HIV-1 RT expressed within bacterial colonies, and isolated two var- iants of recombinant HIV-1 RT bearing the substitutions N255D or ...
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High level of HIV 1 drug resistance among patients with HIV 1 and HIV 1/2 dual infections in Guinea Bissau
... with HIV-1 or HIV-1/2 dual infections that had CD4 cell counts and stored plasma samples acquired before and after 3–12 months of ...ART. HIV-1/HIV-2 discrimination was ...
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Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors
... of HIV-1 Env from a late prebundle configuration into the six-helix bundle, and thereby also slows down the fusion process ...of HIV-1 Env mediated transduc- tion was specific, since ...
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Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1–HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1
... pseudotyped HIV-1 capable of infecting naive epithelial cells, progeny virus collected from VAG, CER, and HeLa cells cocultured with HIV-1– HTLV-1-coinfected T cells was used to infect ...
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Interaction of Reverse Transcriptase (RT) Mutations Conferring Resistance to Lamivudine and Etravirine: Effects on Fitness and RT Activity of Human Immunodeficiency Virus Type 1
... virion-associated RT activ- ity of recombinant HIV-1 carrying mutations that confer resis- tance to the NNRTIs ETV and RPV and the nucleoside re- verse transcriptase inhibitors (NRTIs) 3TC and ...of ...
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Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication
... , Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JML, Lee MJ, Lee ...
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Construction and Operation of an Internal Coil Device, RT-1, with a High-Temperature Superconductor
... An internal coil device called Ring Trap-1 (RT-1) has been constructed to explore an innovative concept for a high-beta plasma based on a new relaxation theory. A high-temperature superconductor ...
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MxB binds to the HIV 1 core and prevents the uncoating process of HIV 1
... to HIV-1 cap- sid in restriction, we tested the ability of MxB to bind in vitro assembled HIV-1 CA-NC complexes bearing the capsid changes P90A, G89V or N57S, which when incor- porated into ...
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Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2
... with HIV-1 were an age of at least 18 years, seroposi- tivity for HIV-1 and HSV-2, a CD4 count of 250 or more cells per cubic millimeter, no conditions associated with acquired ...
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