HLA-A*0201
Lack of strong immune selection pressure by the immunodominant, HLA A*0201 restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus 1 infection
... Antiviral drugs can mediate selective pressure to which the virus readily adapts and even slight advantages in replication rates can allow one strain to dominate the viral population very rapidly (14). One would expect ...
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Identification of Mycobacterium tuberculosis CTL Epitopes Restricted by HLA-A*0201 in HHD Mice
... subtype HLA-A*0201 is one of the most prevalent class I alleles, with a frequency of over 30% in most ...populations. HLA-A*0201 transgenic, H-2D b /mouse beta2- microglobulin double-knockout ...
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HLA A*0201 restricted CD8+T cell epitopes identified in dengue viruses
... HLA-A*0201 transgenic mice were subdivided into 12 groups (4 mice/group). Mice were inoculated subcutane- ously with high-affinity peptide (50 μg/mouse) emulsified in Freund’s complete adjuvant. One week ...
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Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure
... were detected at the mRNA level. Since that there are no TCR V alpha chain-specific antibodies available, we were unable to ascertain whether both chains were expressed on the cell sur- face, thus contributing to two ...
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Immune reconstitution of HLA A*0201/BMLF1 and HLA A*1101/LMP2 specific Epstein Barr virus cytotoxic T lymphocytes within 90 days after haploidentical hematopoietic stem cell transplantation
... This study was a preliminary investigation of the dy- namics of GLC-specific and SSC-specific EBV-CTL re- constitution after haplo-HSCT. Compared with healthy EBV carriers, GLC-specific EBV-CTLs appeared at + 30 days ...
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The Human HLA-A*0201 Allele, Expressed in Hamster Cells, Is Not a High-Affinity Receptor for Adenovirus Type 5 Fiber
... The coxsackie B virus and adenovirus receptor (CAR) and the major histocompatibility complex (MHC) class I a 2 domain have been identified as high-affinity cell receptors for adenovirus type 5 (Ad5) fiber. In this study ...
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Molecular Identification of Pre-Existing Immunityin Human against H9N2 Influenza Viruses Using HLA-A*0201 Binding Peptides
... or HLA in human) is an important host genetic risk factor in viral ...The HLA restriction with CTL plays a major role in the immune response which associated with the host response to the ...supertype ...
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Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope despite Multiple Variations in the Epitope Flanking Sequences
... Figure 3 shows the results for inhibition of HIV-1 isolates with flanking sequence changes. Both patient-derived primary isolates (Table 3) were efficiently inhibited by clone 115D4, indicating efficient processing of ...
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Cytotoxic T-Lymphocyte Responses to Human Papillomavirus Type 16 E5 and E7 Proteins and HLA-A*0201-Restricted T-Cell Peptides in Cervical Cancer Patients
... of HLA-A2 lymphocytes from human healthy donors with rAd-16E5 or ...four HLA-A*0201 binding peptides of HPV-16 E5, peptide E5 63-71, stimulated the largest amount of IFN- ␥ in five ...
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Cytolytic Activity of the Human Papillomavirus Type 16 E711-20 Epitope-Specific Cytotoxic T Lymphocyte Is Enhanced by Heat Shock Protein 110 in HLA-A*0201 Transgenic Mice
... to HLA-A2 in vitro (8, 30, ...in HLA-A2 transgenic mice (32). HLA-A2 is the most frequent HLA-A specificity in the human population, with an allele fre- quency of 10 to 40% in different ethnic ...
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Use of Transgenic HLA A*0201/Kb and HHD II Mice To Evaluate Frequency of Cytomegalovirus IE1-Derived Peptide Usage in Eliciting Human CD8 Cytokine Response
... human HLA Aⴱ0201with the mu- rine ␣3 chain (Kb) (9, 19, ...transgenic HLA Aⴱ0201 mouse that contains a disrupted murine major histocompatibility complex (MHC) molecule, forcing the mouse to present all its ...
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Rapid generation of broad T cell immunity in humans after a single injection of mature dendritic cells
... µM HLA-A*0201 restricted influenza matrix peptide (MP) (GILGFVFTL) (18) and 1 µg/mL HLA-A*0201 restricted HIV gag peptide (SLYNTVATL) (as ...
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8166.full.pdf
... We have identified a peptide, I1Y, which has (i) increased complex stability for HLA-A*0201, (ii) maintains recognition by WT pol-specific CTL lines, and (iii) is more stimulatory for WT[r] ...
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Development of an Artificial-Antigen-Presenting-Cell-Based Assay for the Detection of Low-Frequency Virus-Specific CD8+ T Cells in Whole Blood, with Application for Measles Virus
... MV HLA- A*0201 CD8 ⫹ T-cell epitopes and demonstrated their use in evaluating CD8 ⫹ T-cell responses to MV infection and mea- sles vaccination using HLA-A*0201 tetramers and HLA Ig ...
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Monofunctional and Polyfunctional CD8+ T Cell Responses to Human Herpesvirus 8 Lytic and Latency Proteins
... We next mapped minimal epitope sequences for 10 of these hot-spot peptides. To determine the minimal, optimal epitope, we used peptide families consisting of the putative optimal 9-mer based on anchor residues for ...
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Characterization of human cytomegalovirus peptide-specific CD8<sup>+</sup> T-cell repertoire diversity following in vitro restimulation by antigen-pulsed dendritic cells
... the HLA-A*0201 and HLA-B*0702 tetrameric com- plexes (Figure ...the HLA-B*0702– sorted population was ...the HLA-A*0201–sorted population was also identical but differed from ...
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P53, a potential target for tumor-directed cells
... We identified the p53 peptides with the highest affinity to the HLA-A*0201 molecule using two assays: the peptide binding assay and the peptide competition assay.. The results of both te[r] ...
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Frequency and Phenotype of JC Virus-Specific CD8+ T Lymphocytes in the Peripheral Blood of Patients with Progressive Multifocal Leukoencephalopathy
... tetramer-positive cells was lower than 0.001% in the unstimu- lated CD8 ⫹ T-cell-enriched fraction (Fig. 1A), negligible tet- ramer-positive cells were observed after subsequent in vitro peptide stimulation for 10 to 14 ...
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Cytotoxic T lymphocyte lysis of HTLV 1 infected cells is limited by weak HBZ protein expression, but non specifically enhanced on induction of Tax expression
... of HLA-A*02 expression was observed after incubation with either the Tax-specific CTL clone or the HBZ-specific ...of HLA-A*02, and that the intensity of expression of HLA-A*0201 is more ...
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<p>Dendritic Cell-Based Therapy Using LY6E Peptide with a Putative Role Against Colorectal Cancer</p>
... Generation of carcinoembryonic antigen (CEA)-speci fi c T-cell responses in HLA-A*0201 and HLA- A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded [r] ...
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