HLA class I alleles
Additive Contribution of HLA Class I Alleles in the Immune Control of HIV-1 Infection
... three HLA class I loci, HLA-B plays the dominant role in controlling viral replication, as indicated by steady-state VL and absolute CD4 ...individual HLA alleles associated with ...
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Associations between HLA Class I Alleles and Escape Mutations in the Hepatitis B Virus Core Gene in New Zealand-Resident Tongans
... an HLA class I allele and the presence of nonsynonymous mutations was found at five of these ...the HLA class I alleles that are common in areas where there is a high ...
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Favorable and Unfavorable HLA Class I Alleles and Haplotypes in Zambians Predominantly Infected with Clade C Human Immunodeficiency Virus Type 1
... same alleles lacked any appreciable effect in ...eral class I allele (B*13 and B*39) or haplotype (A*30-Cw*03 and A*23-B*14) associations observed in Zambians have not shown consistent effects in ...
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Protective HLA Class I Alleles That Restrict Acute-Phase CD8+ T-Cell Responses Are Associated with Viral Escape Mutations Located in Highly Conserved Regions of Human Immunodeficiency Virus Type 1
... 76 HLA-associ- ated polymorphisms located at 47 distinct amino acid residues across HIV-1 (see Table S2 in the supplemental ...These HLA-associated mutations were then categorized into four classes based on ...
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HLA class I alleles frequencies in the Syrian population
... Macedonians. HLA-A*24 was the second most frequent HLA-A allele in the studied Syrian popu- lation, this allele was also the second most frequent HLA-A allele in Southeastern European populations, ...
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Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression
... “good,” HLA class I alleles A*11, B*27, B*51, B*57, and B*58 and the “other” HLA class I ...good HLA alleles restricted epitopes which were significantly ...
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Definition of the viral targets of protective HIV 1 specific T cell responses
... between HLA allele and HIV-1 disease outcome ...common HLA class I alleles will likely still call for somewhat population tailored vaccine approaches, especially if the immunogen ...
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Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants
... distinct HLA class I ...had HLA class I molecules in common, the recipient’s CTL response to those epitopes was prevented, thus impeding adequate viral ...when HLA ...
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Human leukocyte antigen class 1 genotype distribution and analysis in persons with active tuberculosis and household contacts from Central Uganda
... agents. HLA diversity plays a crucial role in the host-pathogen interaction and can affect the rates of disease acquisition and outcome ...individual’s HLA profile can determine resistance or susceptibility ...
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Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection
... and HLA-restricted viral escape mutants are a critical aspect of this host-virus ...the HLA types present in two host ...and HLA class I alleles were assessed in 118 individuals ...
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Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1
... of HLA class I alleles associated with a large number of population- level Gag escape associations (16, 30, 65), a large number of re- verting associations (56), and/or a large number of ...
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Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies
... common HLA class I alleles (LCL 1 = HLA-A*01:01, −A*03:01, -B*08:01, -B*35:01 and LCL 2 = HLA-A*02:01, −A*11:01, -B*07:02, -B*44:02), were retrovirally transduced with a ...
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HLA typing from RNA-Seq sequence reads
... The HLA calls for each sample are listed in Table S9 in Additional file ...determined HLA class I alleles from 59 CEU HapMap individuals with European ethnicity (50 Montgomery test ...
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Mapping the Landscape of Host-Pathogen Coevolution: HLA Class I Binding and Its Relationship with Evolutionary Conservation in Human and Viral Proteins
... of HLA binding preferences has been driven by the sequence diversity of short segments of relevant pathogenic proteins presented by HLA molecules to the immune ...in HLA binding preferences, we ...
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The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients
... the HLA class I and II molecules, which have immunologi- cal ...with HLA-DRB1*1501 and nega- tively associated with HLA-DRB1*07 in Caucasian popu- lation ...populations, ...
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Association of HLA alleles with autism
... any HLA haplotypes and ASD in our ...one HLA extended haplotype containing the complement C4B null allele in the class III region, DRB1*04 in the class II region, and A*02 and B*44 ...
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HLA Class II Profile and Distribution of HLA-DRB1 and HLA-DQB1 Alleles and Haplotypes among Lebanese and Bahraini Arabs
... polymorphic class I (HLA-A, -B, and -C) and class II (HLA-DP, -DQ, and -DR) loci, which are subdivided into distinct regions (refer to the IMGT/MLA database for up-to- date listings of ...
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Human Leukocyte Antigens A*3001 and A*3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition
... for HLA-A*3002 (26), indicating a preference for tyrosine residues at the C-terminal position and a preference for hydrophobic or aromatic amino acids at position ...22 HLA-A*3002-binding peptides evaluated ...
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Investigation of Human Leukocyte Antigen (HLA) Class I and II Alleles and Hepatitis C Virus (HCV) Genotypes in Patients Infected with HCV
... Studies have reported the effect of many factors in disease development such as viral factors including viral genotype and viral load, and host factors including age, sex, environment, associated medical conditions as ...
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... while HLA-DRB* had no aff ect on the ...of Class II with Cutaneous manifestations in Japanese population and found a positive malar rash associations with DRB* and skin ulcers with ...between ...
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