HLA class I peptide binding
Computer-Based Design of an HLA-Haplotype and HIV-Clade Independent Cytotoxic T-Lymphocyte (CTL) Assay for Monitoring HIV-Specific Immunity
... of HLA class I peptide-binding motifs by using the Epitope motif search facility at the HIV- Immunology Database covering 94 HLA-class I serotypes (see Methods ...
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Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell mediated function, are present in pooled normal immunoglobulin for therapeutic use
... (13). Class I molecules consist of an MHC-encoded polymorphic a glycoprotein heavy chain of 44-kD and the invariant 12-kD b 2 microglobu- lin ...of class I molecules has shown that the ...
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HLA class I deficiencies due to mutations in subunit 1 of the peptide transporter TAP1
... most HLA class I heavy chain/β2m complexes are retained in the ER and are unstable at ...by binding with exogenous HLA-A–specific pep- tides. HLA-B appeared to be more unstable ...
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The Use of Epstein-Barr Virus-Transformed B Lymphocyte Cell Lines in a Peptide-Reconstitution Assay: Identification of CEA-related HLA-A*0301-Restricted Potential Cytotoxic T-Lymphocyte Epitopes
... MHC class I on a peptide cell line after overnight incu- bation with exogenous peptide, has been used suc- cessfully to detect peptides binding to human leu- kocyte antigen ...expressed ...
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HLA Class I Binding Promiscuity of the CD8 T-Cell Epitopes of Human Papillomavirus Type 16 E6 Protein
... common HLA types by measuring the binding of each of 150 nonamer peptides using purified HLA molecules and radiolabeled ...for HLA- A0201 was tested. Using HLA-A0201 transgenic mice in ...
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Generation of functional CD8+ T Cells by human dendritic cells expressing glypican-3 epitopes
... the binding of a peptide to MHC class I molecules does not necessarily mean that the epitope will be able to induce MHC-restricted CTL, we examined whether these peptides could generate ...
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Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing
... for HLA-B*51-associ- ated selection pressure was only observed in the epitope flanking ...second HLA-B*51 binding motif by analysis with prediction algorithms for HLA class I ...
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The Endoplasmic Reticulum Lumenal Domain of the Adenovirus Type 2 E3-19K Protein Binds to Peptide-Filled and Peptide-Deficient HLA-A*1101 Molecules
... for peptide-filled and peptide-deficient HLA-A11 mol- ecules can be accounted for on the basis of the distinct matu- ration levels of these ...of class I MHC mol- ecules is accompanied ...
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2981.full.pdf
... highest binding affinities, of having mul- tiple viral proteins sampled, and for having epitope sequences conserved among numerous viral isolates (data not ...MHC class I and efficiently targeted by ...
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Evidence for successive peptide binding and quality control stages during MHC class I assembly
... and HLA-Cw4 could be recovered by coim- munoprecipitation with both anti-TAP2 and anti-calretic- ulin antibodies in digitonin lysates, but no association with T134K was ...wild-type HLA-A*0201 and the T134K ...
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Human histocompatibility leukocyte antigen binding supermotifs predict broadly cross reactive cytotoxic T lymphocyte responses in patients with acute hepatitis
... tiple HLA class I alleles with high affinity are recognized as cytotoxic T lymphocyte (CTL) epitopes in acutely infected ...several class I alleles from the HLA-A2–, ...
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Human Leukocyte Antigens A*3001 and A*3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition
... if HLA-A*3001/HLA-A*3002- binding peptides were recognized by CD8 ⫹ T cells from pa- tients with TB and if HLA-A*3001-presented peptides were recognized from T cells obtained from an ...
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Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants
... If HLA class I molecules are shared between partners, the recipient’s ability to mount a response against infection will be impeded, particularly if es- cape has occurred through change at an ...
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Investigating the role of HLA class I derived peptide in alloreactivity
... of peptide related alloresponses are responsible for direct recognition, rather than the single concept outlined in the multiple binary complex ...mismatched HLA and presented by matched HLA, as ...
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Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV resistant prostitutes in Nairobi
... Both class I and II HLA alleles are associated with reduced risk of HIV-1 infection (MacDonald, ...individual class I molecules are with HLA-A*6802, A*0202, and ...these ...
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HLA CLASS I IN IRANIAN P SORIATIC PATIENTS
... A total of 51 unrelated, Iranian caucasian psoriatic patients were studied. A definitive clinical diagnosis of psoriasis was established b y at least two dennatologists in Razi hospital, a dennatologic center in Tehran, ...
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beta2 Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma
... of HLA class I antigen expression by melanoma cell lines Me18105, Me9923, and ...restored HLA class I antigen expression and, in Me18105 cells, recognition by ...
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Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review
... the HLA poly- morphism in cases and controls ...assessed HLA poly- morphism in visceral leishmaniasis including a large scale multicentre study in Brazil and India [45], but not for cutaneous ...no ...
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Lack of HLA class I antigen expression by cultured melanoma cells FO 1 due to a defect in B2m gene expression
... gene. HLA class I antigen expression was reconstituted on melanoma cells FO-1 after transfection with the wild-type mouse B2m gene, thereby confirming the abnormality of the endogenous B2m ...of ...
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HLA and proteasome expression body map
... of HLA expression in these substructures revealed very similar median classical HLA class I and HLA class II expression levels within the same tissue (Additional file 2: Figure ...
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