HLA-DR
Original Article Amino acids at positions 30β1 and 57β1 of HLA-DR confer susceptibility to or protection from chronic hepatitis B virus infection
... In HLA-DR molecules, HLA- DRα1 chain encoded by HLA-DRA is almost an invariant chain, but HLA-DR β1 chains encoded by HLA-DRB alleles show high ...of HLA class II ...
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Indirect recognition of donor HLA DR peptides in organ allograft rejection
... To our knowledge the present study describes for the first time the kinetics of indirect allorecognition in patients with or- gan allografts. These investigations demonstrate that in heart transplantation the ...
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Epidermal HLA DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis
... increased proliferative response to SAg’s correlated with extent of disease activity (44). The increased cytokine gene and protein expression in psoriatic skin treated with SEB suggests an intrinsic psoriasis epider- mal ...
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Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL 1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL 1Ra 2/2 genotypes on disease susceptibility
... les have been suggested as a minor risk factor in suscepti- bility to SLE in several populations [8,10,12]. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring com- petitive inhibitor of IL-1. The IL-1Ra ...
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The HLA DRB1 locus as a genetic component in giant cell arteritis Mapping of a disease linked sequence motif to the antigen binding site of the HLA DR molecule
... demonstrated heterogeneity for the sequence polymorphism of the third hypervariable region (HVR), but homology for the polymorphic residues within the HVR2 of the HLA- DRB1 gene. The GCA patients shared a sequence ...
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Myofiber HLA-DR expression is a distinctive biomarker for antisynthetase-associated myopathy
... Myofiber HLA-DR expression was ascribed to the presence of interferon (IFN)γ in the microenvironment of myofi- bers ...ASM, HLA-DR immunostaining was proposed as a marker of inflam- matory ...
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Original Article Expression of monocyte HLA-DR and blood lactic acid level in patients with sepsis and correlation with prognosis
... Chen et al. investigated the relationship be- tween the dynamic changes of monocyte HLA- DR expression rate and the prognosis of sep- sis. Results showed that patients with dynamic decline of expression ...
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HLA-DR expression on monocytes is decreased in polytraumatized patients
... monocyte HLA-DR expression fell within hours of trauma or surgery, but returned to normal within 1 week [6, ...for HLA-DR expression to return to base level in those who developed infection, ...
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Original Article Overexpression of HLA-DR is associated with prognosis of glioma patients
... Western blotting: Tumor tissues and normal tis- sues were completely homogenated, then were qualified by the method of Coomassie brilliant blue (CBB). Same amount of protein were test- ed by SDS-PAGE and transfered with ...
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The role of platelet microparticles in the production of antibodies from B lymphocytes against HLA-DR antigen in vitro
... anti-human HLA-DR monoclonal antibody (OriGene Technologies, USA) to Cyanogene bromide-activated sepharose 4B according to the manufacturer's instructions and preparing the chromatography column, the cell ...
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Expression of HLA-DR genes in gliomas: correlation with clinicopathological features and prognosis
... the HLA- DRA gene, while the β-chain is mainly encoded by 4 genes, including HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5 ...high HLA-DR expression had a significantly lower ...
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HLA DR and HLA DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance
... loci, HLA-A, -B, and -C, bind peptides of intra-cellular origin and present them to CD8+T cells, resulting in the death of cells infected by ...loci, HLA-DR, -DQ, and -DP, pri- marily bind peptides ...
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The Polyomavirus BK Large T-Antigen-Derived Peptide Elicits an HLA-DR Promiscuous and Polyfunctional CD4+ T-Cell Response
... diverse HLA-DR types were reactive to ...strict HLA-DR restriction is not a prerequisite for the devel- opment of a successful cell-mediated immune response to ...stringent ...
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Prognostic Value of CD74 and HLA DR Expressions in Invasive Ductal Breast Cancer
... and HLA-DR expressions on the prognosis of patients who have had a mastectomy for the treatment of breast ...and HLA-DR expression and the level of tumor infiltrating lymphocyte ...Similarly, ...
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Impaired Regulation of HLA-DR Expression in Human Immunodeficiency Virus-Infected Monocytes
... target HLA-DR molecules to endosomal processing compart- ments, a 33-kDa isoform and a 35-kDa isoform ...with HLA-DR, is targeted to late endosomes and lysosomes via dileucine-based motifs ...
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An effective and effecient peptide binding prediction approach for a broad set of HLA-DR molecules based on ordered weighted averaging of binding pocket profiles
... Here, we evaluate the OWA-PSSM method on a large- scale MHC II ligand dataset. This dataset covers 1164 HLA-DR ligands restricted to 28 HLA-DR alleles [5,14]. We applied a similar approach as ...
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Gamma interferon induces different keratinocyte cellular patterns of expression of HLA DR and DQ and intercellular adhesion molecule I (ICAM I) antigens
... In normal skin, both HLA-DR and HLA-DQ are found on the same cells, namely vascular endothelium,** Langerhans cells'* and the acrosyringial epithelium.'^ Under normal circumstances neith[r] ...
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Decreased HLA DR antigen associated invariant chain (CD74) mRNA expression predicts mortality after septic shock
... Results: A significant correlation was found among MHC class II related gene expressions. Among mRNA markers, the best prognostic value was obtained for CD74 (HLA-DR antigen-associated invariant chain). For ...
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A diabetes susceptible HLA haplotype is best defined by a combination of HLA DR and DQ alleles
... these DR and DQ alleles in ...both DR and DQ loci; (b) that the combination of certain DR and DQ alleles marks haplotypes with the true susceptibility allele at a third locus; or (c) that Dw4 and 10 ...
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Sputum Changes In Children With Obstructive Bronchitis
... and HLA-DR receptors in induced sputum is different in patients with asthma and chronic obstructive bronchitis and in both groups depends on the period of the disease and the therapy ...
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