HLA loci associated with MS
Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk
... was associated with a 2-fold elevated risk of SCC, and contained three individually significant alleles (B*4402, Cw*0501, and ...specific HLA alleles or HLA-linked genes. As genotyping of the ...
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Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk
... was associated with a 2-fold elevated risk of SCC, and contained three individually significant alleles (B*4402, Cw*0501, and ...specific HLA alleles or HLA-linked genes. As genotyping of the ...
28
High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.
... known HLA alleles that were typed directly in our sample, together with a second set of 38 common SNPs, which had low pairwise LD and were distributed uniformly across the classical HLA ...the HLA ...
12
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
... independent loci in the MHC region that are associated with CIAG: HLA-DQB1 and ...and HLA-B 158T), but cannot distinguish whether these amino acids are causal or if the overall configuration ...
23
Genetic studies of non-HLA loci in rheumatoid arthritis : expression and interaction of candidate genes
... II HLA, including HLA-DRB1, gives it a promising role as a gene candidate to study for autoimmune ...RA, MS and MI (myocardial infarction) [55] it became a target for many replication ...
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Common HLA alleles associated with health, but not with facial attractiveness
... specific HLA class I alleles and resistance to chronic Hepatitis B [28], malaria [29] and delayed progression to AIDS ...at HLA loci, which may be driven by less frequent diseases or by inbreeding ...
8
Amplified fragment length polymorphism typing of HLA-DPB1 and associations with IDDM and MS
... fourth HVRs on DPB1. By combining allele frequencies based on HVR similarities, associations of putative epitopes shared by different DPB1 alleles can be assessed. This approach has been used for other HLA ...
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Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
... strongly associated SNP, was also significantly associated with a higher susceptibility to EGFR mutation-positive LADC (Supplementary Table 14), indicating that ...is associated with a higher risk of ...
8
The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA
... epitope-specific HLA DSA [20–22, 24–28]. Although the immunogenicity of HLA molecules is dependent on the mismatched amino acid residues between the donor and the recipient and on the number and ...
13
Non HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA defined subgroups of rheumatoid arthritis
... The HLA-DRB1 locus is known as the most important genetic contributor for the risk of RA, but is not sufficient to drive autoimmunity and additional genetic and environmental factors are ...RA loci with ...
12
HLA C increases HIV 1 infectivity and is associated with gp120
... the HLA-C gene, 35 kb away from transcription initiation and has been reported to be associated with differences in HLA-C expression levels ...gene, HLA- C has the potential to restrict HIV-1 ...
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Contrasting roles of interallelic recombination at the HLA-A and HLA-B loci.
... Allelic phylogenies: Phylogenetic trees were con- structed for A (Figure 3) and B (Figure 4) locus alleles of human and chimpanzee by the neighborjoining method (S[r] ...
12
Organic solvents and MS susceptibilityInteraction with MS risk HLA genes
... exposure strongly suggests that these environmental risk factors mechanistically act on the adaptive immunity. The previous findings that smoking and exposure to passive smoking, 10,11 but not oral tobacco, 17 increase ...
9
HLA-B27 ASSOCIATED UVEITIS
... This condition is present in 1 in 1000 to 1 in 2000 of the white population; it shows a lower incidence in Blacks and Asians. It is was traditionally considered more common in males, but it is now recognized that it may ...
9
HLA allele frequencies in Iranian opticospinal multiple sclerosis patients——HLA in Opticospinal MS
... 1 MS Research Center, Mehr and Loghman Hospital Shahid Beheshti, University of Medical Sciences,Tehran, Iran; 2 Bahar Medical Laboratory, Department of Immunology and Transplantation, Tehran, Iran; 3 Loghman ...
5
Takayasu's arteritis is associated with HLA B*52, but not with HLA B*51, in Turkey
... of HLA-B*52 and HLA-B*51 alleles, DNA was amplified using the forward primers HLA 192 and HLA 193, respectively, and reverse primer HLA 216 (for both) for the specific product with ...
5
HLA-DRB1 Al allele Interaction and Network Analysis in MS
... There may well be similar effects from other DRB1 resistance alleles of lower frequency or with smaller effect size on outcome, which might be most efficiently sought by using larger numbers of extremes. Given the ...
6
Detecting signatures of past pathogen selection on human HLA loci : are there needles in the haystack?
... two HLA loci in the host r Each individual’s genotype is explicitly simulated, making it possible to simulate recombination between maternal and paternal chromosomes in either the mother or the father when ...
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Selection, hitchhiking and disequilibrium analysis at three linked loci with application to HLA data.
... Using the criteria of a large positive 6 value as a test to identify a selected allele will be very conservative; only certain combinations of initial allele frequenc[r] ...
18
HLA-B27 Positivity: associated health implications
... Medical management of AAU involves the use of topical or systemic corticosteroids and topical cycloplegics. Occasionally, in recalcitrant or noncompliant cases and when the posterior segment is also involved ...
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