Host responses
Respiratory viral infections and host responses; insights from genomics
... interferon responses [117, ...aberrant host responses resulting in mortality, whereas the poly- merase and NP proteins confers high viral loads, but does not induce lethal disease ...1918-induced ...
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Characterization of early host responses in adults with dengue disease
... [4], non-small lung cancer cells [5], HepG2 [6,7]; pri- mary human immune cells [8] and muscle satellite cells [9]; to whole blood or isolated mononuclear cells from DENV-infected patients [10-14], the first studies ...
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Spatially resolved transcriptomics reveals plant host responses to pathogens
... We analysed all clusters for enriched biological pro- cesses using GO-term analysis. We could not detect any enrichment in biological processes for the cluster con- taining the DE genes which were lower expressed at the ...
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Cell to Cell Variation in Defective Virus Expression and Effects on Host Responses during Influenza Virus Infection
... virus- host interactions have been greatly facilitated by the application of fast-evolving single-cell RNA-seq approaches (reviewed in reference ...cellular responses, especially the innate antiviral ...
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Recent advances in our understanding of human host responses to tuberculosis
... in host responses against tuberculosis, and the TLR-mediated stimulation of interleukin-12 was itself medi- ated through the transcription factor nuclear ...the host response against M ...
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Host responses to interspecific brood parasitism: a by-product of adaptations to conspecific parasitism?
... The evolution of fine-tuned egg discrimination is un- necessary in the absence of parasitic eggs that closely re- semble those of hosts, e.g., from conspecific parasites or interspecific parasites with closely mimetic ...
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Host responses to concurrent combined injuries in non-human primates
... The ideal MOF model on which to preclinically test immunomodulatory strategies should address these issues by selecting an appropriate large animal model that most closely resembles the human genetic, im- munologic, and ...
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A practical method for preparation of pneumococcal and nontypeable Haemophilus influenzae inocula that preserves viability and immunostimulatory activity
... Findings: S. pneumoniae and NTHi retained >90% viability following cryopreservation in fetal calf serum for at least 8 weeks. Host responses to live, cryopreserved (1 week and 4 weeks), heat-killed or ...
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Host Immune Responses to Chronic Adenovirus Infections in Human and Nonhuman Primates
... modulating host responses to virus infection, did demonstrate structural differences that may further explain the apparent differences in host ...of host responses and a different ...
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Phytoalexin-Deficient Mutants of Arabidopsis Reveal That PAD4 Encodes a Regulatory Factor and That Four PAD Genes Contribute to Downy Mildew Resistance
... isolate involves a different signaling pathway for host responses than other RPP genes. Genetic dissection of host defense responses using the Arabidopsis model system is [r] ...
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Transcriptional profiling of host cell responses to encephalomyocarditis virus (EMCV)
... between host and virus is largely unknown, ...and host cell pathological re- sponses triggered by EMCV ...subsequent host responses to the virus are significant to understand host ...
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Differences in Host Innate Responses among Coccidioides Isolates in a Murine Model of Pulmonary Coccidioidomycosis
... susceptible host inhales the conidia, a transition to mature endosporulated spherules can occur within the first 5 days of ...the host response in a murine model of coccidioidomycosis dur- ing a time period ...
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hsp72, a Host Determinant of Measles Virus Neurovirulence
... immunocompetent host, hsp72-dependent increases in MV gene expression can facilitate immune clear- ance by overcoming host-restricted low levels of viral gene expression that otherwise promote viral ...
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Modulation of host signaling and cellular responses by Chlamydia
... the host cell via the TTSS ...the host Arp2/3 complex emphasizing the complexity of bacterially induced cytoskeletal modulation [65,66] (Figure ...with host AHNAK and actin ...
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The generation of oxygen radicals during host plant responses to infection
... stimulate superoxide initiated lipid peroxidation in plant cells [35]. In both the hypersensitive response and paraquat treatment, a lowering in the level of membrane unsaturation was observed [76], consistent with the ...
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Modulating host immune responses to fight invasive fungal infections
... Immune modulation in HIV-associated mycoses remains complicated by the risk of immune reconstitution inflammatory syndrome and although exogenous interferon-gamma therapy may be benef[r] ...
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Optimization of the Timing of Induction for the Assessment of Nitric Oxide Production in Leishmania major Infected Macro-phage Cells
... which lack flagellum and reside in mammalian host macrophages, and promastigotes, which have anterior flagella found in the body of sandflies and culture media (1). Phagocytosis and anti-leishmanial activity of ...
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Host immune responses to the itch mite, Sarcoptes scabiei, in humans
... IL-17 is a potent proinflammatory cytokine, commonly recognised to be secreted by Th17 cells but it is also se- creted by other cell types such as γδ + and CD8 + T cells. Th17 cell generation and IL-17 secretion is ...
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Modelling host evolutionary responses to infection
... a host first becomes infected with cells but there has been insufficient time for the cells to replicate to the point that they can be transmitted to other ...single host can infect, a term which is called ...
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Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys
... Plasma and milk SIVsab env variants exhibit similar neutral- ization sensitivity. To determine if neutralization sensitivity dif- fers between plasma and milk SIVsab variants and accounts for the anatomic ...
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