Hot Melt Extrusion
RECENT ADVANCES IN HOT MELT EXTRUSION TECHNOLOGY
... Melt extrusion process which is well known in the polymer and food industry is now being used for pharmaceutical manufacturing to create innovative new formulations and is a continuous process of mixing and ...
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SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IVACAFTOR TABLETS BY USING SOLID DISPERSION TECHNIQUE OF HOT MELT EXTRUSION A DESIGN OF EXPERIMENTAL APPROACH
... In the present study, the SDs of the poorly soluble drug substance Ivacaftor were successfully prepared using HME. The in vitro dissolution test shows a significant increase in dissolution rate of SDs prepared by HME ...
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DISSOLUTION ENHANCEMENT OF POORLY WATER SOLUBLE EPROSARTAN BY HOT MELT EXTRUSION TECHNIQUE
... pressure. Hot melt extrusion (HME) is the process of applying heat and pressure to melt a polymer and force it through an orifice in a continuous ...by hot melt extrusion ...
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Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion
... The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both ...
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Development and Characterisation of Natamycin Mini Matrices Prepared by Hot Melt Extrusion for Vaginal Delivery
... years, hot-melt extrusion technology has gained popularity due to pharmaceutical applications of poorly water-soluble ...In melt extrusion processes, the drug/carrier powder blend is ...
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A COMPARATIVE STUDY OF LEDIPASVIR SOLID DISPERSION TECHNIQUE USING SPRAY DRYING AND HOT MELT EXTRUSION
... and hot-melt extrusion by using various carriers like polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (soluplus), hypromellose 5 cPs and copovidone (kollidonVA64) to ...
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Solvent-free Hot Melt Extrusion Technique in Improving Mesalamine Release for Better Management of Inflammatory Bowel Disease
... by Hot-Melt Extrusion (HME) technique could be utilized for better management of Inflammatory Bowel Disease ...were hot-melt extruded using a co-rotating twin-screw laboratory ...
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Hot melt extrusion method for preparation of ibuprofen/sucroester WE15 solid dispersions: evaluation and stability assessment
... Low melting points Sucroesters (SEs) are used in hot-melt extrusion technology (HME). However, there are few literatures studying the effect of SEs on drug release and their storage stability. In ...
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“HOT-MELT EXTRUSION” by Sachin Mamidwar, Shrikant Hodge, Dr. Vilas Deshmukh, Vishal Borkar, India.
... Hot-melt extrusion (HME) is one of the most widely applied processing technologies in the plastic, rubber and food ...processing. Melt extrusion is considered to be an efficient ...
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FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY OF VALSARTAN USING HOT MELT EXTRUSION TECHNIQUE
... utilizing hot melt extrusion technique (HME). Hot melt extrudates were prepared by novel polymeric matrices such as HPMCAS and Plasdone S630 copovidone at different ...its ...
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FORMULATION AND EVALUATION OF NOVEL FLOATING CONTROLLED RELEASE DRUG DELIVERY SYSTEM OF LAFUTIDINE PREPARED BY HOT-MELT EXTRUSION METHODDr. Amit singh, N.Sandeepthi*, Dr.L.SatyanarayanaDOWNLOAD/VIEW
... form. Hot-melt extrusion (HME) has recently emerged as a novel processing technology in the development of molecular dispersions in polymer and lipid carriers for the preparation of controlled, ...
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Use of Terahertz-Raman spectroscopy to determine solubility of crystalline API in polymeric matrices during hot melt extrusion
... In this work, terahertz (THz) Raman spectroscopy was introduced as a novel empirical approach to determine the saturated solubility of crystalline active pharmaceutical ingredient (API) in polymeric matrices directly ...
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DESIGN AND EVALUATION OF BILAYER TABLETS OF GLIMEPIRIDE AND METFORMIN HYDROCHLORIDE WITH COMBINATION OF HYDROPHILIC AND HYDROPHOBIC POLYMERS BY HOT MELT EXTRUSION
... The aim of the present study was to design and evaluate bilayered tablets of metformin hydrochloride as sustained release (SR) and glimepiride as immediate release form for the treatment of diabetes mellitus. Immediate ...
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HOT MELT EXTRUSION AND FREEZE PELLETIZATION: BETTER ALTERNATIVE FOR DRUGS HAVING STABILITY PROBLEM DUE TO PRESENCE OF WATER
... novel hot-melt extrusion and freeze pelletization technique, recently reported to produce spherical pellets, eliminates problem associated with other ...Today melt extrusion technology ...
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Enhancing Dissolution and Bioavaibility of Purely Water Insoluble Natural Compounds by Solid Dispersion with Hot Melt Extrusion Technique
... The use of herbal remedies is still a trend in the world, especially Indonesia as the second largest country after Brazil is rich in medicinal plants, in addition to having many pharmacological properties also have low ...
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“Enhancement of Dissolution of Felodipine: A Thermostable Compound by Hot-Melt Extrusion Solid Dispersion Approach” by S. Kaushik, Kamla Pathak, India.
... The objective of this study was to prepare and evaluate the Felodipine (FEL), solid dispersions (SDs) with polyethylene glycol (PEG) 6000, a hydrophilic carrier, by using hot melt extrusion (HME) ...
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SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF ANTIFUNGAL VORICONAZOLE BY HOT MELT EXTRUSION AND DEVELOPMENT OF SUSTAINED RELEASE TABLETS
... This work studied Voriconazole 27,28 solid dispersion (SD) 4,5 formulation using mixture of Soluplus & KollidonVA64 melts at temperatures lower than the melting point of Voriconazole using a twin screw rotating ...
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SOLUBILITY ENHANCEMENT OF BOSENTAN MONOHYDRATE BY USING HOT MELT EXTRUSION TECHNIQUE
... Bosentan is the free sample provided by Matrix API team. The polymers used in the hot melt extrusion process soluplus and kol- lidon VA 64 was the free samples provided by BASF. The active ...
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A novel hot-melt extrusion formulation of albendazole for increasing dissolution properties
... This physical transformation of the drug can be achieved by 53 Hot-Melt Extrusion HME in order to deliver an amorphous solid dispersion with increased 54 dissolution properties, which is[r] ...
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Hot melt extrusion technique and its pharmaceutical applications: A review
... [11]. Hot-melt extrusion is the process of pumping raw materials with a rotating screw under elevated temperature through a die into a product of uniform ...
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