HPV 16
Potential Natural Inhibitor Bioactivities against High-Risk HPV-16, HPV- 18 and HPV-52 of E6 Oncoprotein through Molecular Docking Vivitri D. Prasasty*, Ignatia Eveline, Ekaristy J. Noya
... E6 HPV-16, 18 and 52 were performed in Table ...E6 HPV-16, 18 and 52 were further computed with calculation scores were 93%, 87% and 95%, respectively which indicated that the protein ...
7
HPV 16, HPV 58, and HPV 33 are the most carcinogenic HPV genotypes in Southwestern China and their viral loads are associated with severity of premalignant lesions in the cervix
... between HPV subtype and cervical path- ology status presented in this study may supply guidance for HPV vaccination programs and preventative strat- ...prevalent HPV subtypes were HPV-52, ...
8
Human Papillomavirus Type 16 (HPV-16) Virus-Like Particle L1-Specific CD8+ Cytotoxic T Lymphocytes (CTLs) Are Equally Effective as E7-Specific CD8+ CTLs in Killing Autologous HPV-16-Positive Tumor Cells in Cervical Cancer Patients: Implications for L1 Dendritic Cell-Based Therapeutic Vaccines
... of HPV-16 was generated using a previously characterized plasmid encoding glutathione S-transferase (GST) E7 fusion protein as previously described ...terized HPV-16 L1-VLPs were kindly ...
11
Multiple ASF/SF2 Sites in the Human Papillomavirus Type 16 (HPV-16) E4-Coding Region Promote Splicing to the Most Commonly Used 3′-Splice Site on the HPV-16 Genome
... of HPV-16, ASF/SF2 is required primarily for splicing to ...of HPV-16 mRNAs that are efficiently expressed in HPV-16-infected cells ...1). HPV-16 E6 and E7 mRNAs ...
12
Human papillomavirus (HPV) types 16, 18, 31, 45 DNA loads and HPV 16 integration in persistent and transient infections in young women
... [41]. HPV has developed several mechanisms to evade the host immune system ...between HPV-encoded proteins could also explain why some types and variants have a better viral fitness with a greater ability ...
12
Regression of Established Human Papillomavirus Type 16 (HPV-16) Immortalized Tumors In Vivo by Vaccinia Viruses Expressing Different Forms of HPV-16 E7 Correlates with Enhanced CD8+ T-Cell Responses That Home to the Tumor Site
... type 16 (HPV-16) E7 fused to a nonhemolytic portion of the Listeria monocytogenes virulence factor, listeriolysin O (LLO), induces an immune response that causes the regression of established ...
11
More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV 16) and HPV 18: a study of oral HPV and oral HPV antibodies in a normal healthy population
... elucidated. HPV infection has been shown to play an important role in all anogenital cancers with HPV seropositivity in men and women vary- ing according to the site of HPV infection ...of HPV ...
10
Human Papillomavirus Type 16 (HPV-16) Genomes Integrated in Head and Neck Cancers and in HPV-16-Immortalized Human Keratinocyte Clones Express Chimeric Virus-Cell mRNAs Similar to Those Found in Cervical Cancers
... HR HPV types that replicate efficiently and persist in primary human keratinocytes, such as HPV-16, HPV-31 (32, 34, 35), and to a more limited extent HPV-18 (28, ...extrachromosomal ...
10
Human Papillomavirus 16 (HPV 16) and HPV 18 Antibody Responses Measured by Pseudovirus Neutralization and Competitive Luminex Assays in a Two- versus Three-Dose HPV Vaccine Trial
... detectable HPV 16 DNA at baseline; however, anti-HPV 18 responses at 7 months were higher for baseline HPV 18 DNA-positive subjects, but the difference was not statistically ...baseline ...
6
PDZRN3/LNX3 Is a Novel Target of Human Papillomavirus Type 16 (HPV-16) and HPV-18 E6
... 12. Kranjec C, Banks L. 2011. A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose ...
6
A Systematic Analysis of Human Papillomavirus (HPV) E6 PDZ Substrates Identifies MAGI-1 as a Major Target of HPV Type 16 (HPV-16) and HPV-18 Whose Loss Accompanies Disruption of Tight Junctions
... by HPV-16 and HPV-18 ...by HPV-18 E6 than by HPV-16 E6, and the reverse is true for ...by HPV-18 E6 but less so by HPV-16 E6, and this is in agreement with ...
8
Human Papillomavirus 16 (HPV-16), HPV-18, and HPV-31 E6 Override the Normal Phosphoregulation of E6AP Enzymatic Activity
... on HPV-16 or HPV-31 E6-induced autodegradation of E6AP but does affect HPV-18 E6-induced autodegradation of ...that HPV E6 overrides the normal phosphoregulation of E6AP, both in terms ...
12
Detection of Neutralizing Antibodies against Human Papillomaviruses (HPV) by Inhibition of Gene Transfer Mediated by HPV Pseudovirions
... using HPV pseudovirions generated in ...of HPV virus-like particles (VLPs) was improved by using direct interaction between a reporter plasmid and the ...generate HPV-16 and HPV-31 ...
7
Human Papillomavirus Type 16 Integration in Cervical Carcinoma In Situ and in Invasive Cervical Cancer
... episomal HPV genome and that integrated HPV genome forms would have the E2 target deleted or ...the HPV episomal form in relation to the integrated ...of HPV-16 E1/E2 genes by ...of ...
8
Comparison of Variant Specific Hybridization and Single Strand Conformational Polymorphism Methods for Detection of Mixed Human Papillomavirus Type 16 Variant Infections
... of HPV-16 variants that each method can detect, the labor intensity of each method, and the ability of each method to accurately identify mixed HPV-16 variant ...mixed HPV-16 ...
7
Co occurrence of human papillomavirus (HPV) in newborns and their parents
... neonatal HPV 16/18 infection, like to that observed in Bandyopadhyaya’s et ...of HPV infected mother have an increased risk of infection [9, 12, ...of HPV infection acquired during peri- natal ...
5
Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7.
... Since extension of the life span is characteristic of the human fibroblasts transformed by the whole HPV-16 genome 22, we concluded that transfection with HPV-16 E6E7 DNA fragments induc[r] ...
5
Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model
... functions, including IFN-γ production and tumor cell killing. Multiple head and neck and cervical cancer cells lines were recognized; no cell lines that expressed the targeted peptide-MHC complex were not recognized. In ...
13
Highly Effective Detection of Human Papillomavirus 16 and 18 DNA by a Testing Algorithm Combining Broad Spectrum and Type Specific PCR
... of HPV genotype 11, 16, 18, or 44 were used as the amplification targets in various ...11, 16, and 18), and ...between HPV-16 and -44 and also between HPV-11 and HPV-18 ...
7
Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.
... risk HPV-associated lesions to progress to ...anogenital HPV-6 and HPV- 11, encode E7 proteins that are demonstrably less efficient than HPV-16 E7 in binding to and inactivating this ...
14