Hsc70/Hsp70
Primate Chaperones Hsc70 (Constitutive) and Hsp70 (Induced) Differ Functionally in Supporting Growth and Prion Propagation in Saccharomyces cerevisiae
... heterologous Hsp70’s we find that primate Hsc70 supported growth but iHsp70 did ...Plant Hsc70 and iHsp70 counterparts behaved similarly, implying evolutionary conservation of this ...primate ...
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The Cellular Chaperone Hsc70 Is Specifically Recruited to Reovirus Viral Factories Independently of Its Chaperone Function
... chaperone Hsc70 is thought to be involved in the uncoating of reovirus par- ticles during virus entry, and Hsp70 is required for posttransla- tional folding and assembly of the globular portion of the ...
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Extracellular heat shock protein 70 has novel functional effects on sea urchin eggs and coelomocytes
... the Hsc70 immunofluorescence pattern with the distribution of egg endoplasmic reticulum shown by Henson et ...of Hsc70 in cells (Dastoor and Dreyer, ...extracellular Hsc70 appears to be able to pass ...
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Polier, Sigrun (2009): Structural Basis for the Cooperation of Hsp110 and Hsp70 Molecular Chaperones in Protein Folding. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... cognate Hsp70 partners, Kar2p and Hsc70, respectively (Steel et ...the Hsp70 PBD Sse1p- bound ATP is not ...ATP-complexed Hsp70 NBD at a precatalytic ...from Hsp70 does not depend on ...
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The Peptide-Binding and ATPase Domains of Recombinant hsc70 Are Required To Interact with Rotavirus and Reduce Its Infectivity
... protein hsc70 (20); whether these last three interactions occur sequentially or alternatively has not been ...with hsc70 is mediated by a domain in VP5 located between amino acids 642 and 659 of the ...
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In vivo and in vitro association of hsc70 with polyomavirus capsid proteins.
... of hsp70-like proteins are to maintain protein homeostasis during protein synthesis and transport and to be a response to protein damage caused by chemical and physical agents ...(14). hsc70 transiently ...
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Engineering heat tolerance in potato by temperature dependent expression of a specific allele of HEAT SHOCK COGNATE 70
... of HSc70 correlates with the acquisition of thermotolerance as well as an increase in tolerance to water deficit and salt stress (Alvim et ...decrease HSc70 expression levels using a transgenic approach ...
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Association of Simian Virus 40 Vp1 with 70-Kilodalton Heat Shock Proteins and Viral Tumor Antigens
... distinct HSP70 bind- ing patterns for three regions of SV40 ...both Hsc70 and Hsp70 in an energy-dependent ...pentamer, HSP70 recruitment is still dependent on ATP and further requires ...
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A Role for Molecular Chaperone Hsc70 in Reovirus Outer Capsid Disassembly
... as Hsc70. Immunodeple- tion of Hsc70 and Hsp70 impaired ␦ release, which was then rescued by addition of purified ...Hsc70. Hsc70 was associated with released ␦ molecules not only in ...
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BAG2 structure, function and involvement in disease
... of Hsp70/Hsc70 molecular chaperones [3, 4]. By binding to Hsp70 at a binding site that overlaps with the Hip binding site, BAG family proteins stimulate ADP/ATP exchange and repress co-chaperone Hip ...
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Chaperone-Mediated In Vitro Disassembly of Polyoma- and Papillomaviruses
... resident Hsp70 family chaperone BiP by 3 hpi and subsequently can be detected in perinuclear regions (19, ...for Hsc70/BiP functioning in the uncoating of poly- oma- and papillomaviruses, previous studies ...
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Temperature interactions of the molecular chaperone Hsc70 from the eurythermal marine goby Gillichthys mirabilis
... of heat-shock proteins (Hsps); the Hsps most involved in protein folding are members of the Hsp40, Hsp60 and Hsp70 families (Gething, 1997; Fink, 1999). Within each Hsp gene family, there are different forms of ...
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Cucumber Necrosis Virus Recruits Cellular Heat Shock Protein 70 Homologs at Several Stages of Infection
... of HSP70 family homologs is to facilitate the chloroplast import of cytoplasmically synthesized cellular chloroplast preproteins (54, ...a HSP70 family homolog(s), we conducted silencing experiments through ...
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Effect of Ethinylestradiol on hsp70 Expression in Transgenic Drosophila melanogaster (hsp70-lacZ) Bg9
... induce hsp70 significantly (compared to control) as is evident by the β- galactosidase activity in third instar larvae of Bg 9 at ...of hsp70. Expression of hsp70 in the tissues was found to increase ...
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The Effect of 200Gy 60Co-γ Radiation on the Body Stress Responses Sensitivity and Reproductive Reaction of Plutella xylostella (Linnaeus)
... protein genes hsp70s and hsc70 and their associated mRNA expression under heat stress. 361[r] ...
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Fusion of Hsp70 to Mage a1 enhances the potency of vaccine specific immune responses
... to Hsp70 can in- crease the potency of vaccination against Mage-expressing tumors, we expressed Mus musculus Mage-a1, Hsp70, and Mage-a1-Hsp70 fusion proteins using the prokaryotic ex- pression ...
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Identification of the HSP70 II gene in Leishmania braziliensis HSP70 locus: genomic organization and UTRs characterization
... of HSP70 genes composing the locus, and possible sequence divergence existing between the different genes, we designed specific oligonucleotides to cloning the complete intercoding regions (UTRs+intergenic ...
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Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself
... human HSP70 induced pro-TNF-a pro- duction in cultures of primary human macrophages, and that these responses were blocked with an antagonistic anti-TLR4 antibody (Figure ...the HSP70 protein itself, or any ...
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HSP70 mRNA expression by cells of the epithelial rest of Malassez due to mechanical forces in vitro
... Total RNA was extracted using the acid guanidium thio- cyante/phenochloroform method, using a total RNA isola- tion reagent (Trizol Reagent, Invitrogen,USA) according to the manufacturer’s instructions. The RNAs were ...
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Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
... compartments, and targeting of misfolded or abnormal proteins for degradation. Many aspects of protein–protein interactions are also specifically regulated by chaperones. The accumulation of unfolded proteins in the ...
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