HSP60-C
HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway
... that HSP60, an important mitochondrial chaperone protein, which gets upregulated in microglia in response to IL-1β treatment, acts as a key hub ...that HSP60 regulates IL-1β-induced inflammation in micro- ...
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Novel therapeutic vaccine for Diabetes mellitus: Literature Review
... (and hsp60) can also exert direct effects on the immune system. Hsp60 can activate beta-cells via the Toll like receptor 4 (TLR4), which respond by producing ...by hsp60 also occurs in macrophages ...
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HSP60, a protein downregulated by IGFBP7 in colorectal carcinoma
... 1. HSP60 protein may be a key molecule enrolled in CRC initiation and ...of HSP60 may participate in, at least in part, the growth inhibiting role of IGFBP7 on colon cancer ...and HSP60 could ...
9
HSP Roles as Biomarkers and Antigens in Bacterial and Viral Infections
... anti-microbial Hsp60 antibodies with human ...coli Hsp60 was also used in the pathogenesis of autoimmune rheumatic [50] and pancreatic [51] diseases, and Sjogren syndrome ...endogenous Hsp60 could ...
7
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling
... chaperone HSP60 is reduced in diabetes and influences insulin ...by HSP60 deficiency ...of HSP60 increases insulin sensi- tivity remains ...of HSP60 has been shown to reduce oxidative stress ...
15
Selective response of gamma delta T-cell hybridomas to orthomyxovirus-infected cells.
... been chilled at 2 20 8 C. The slides were air dried or left overnight at 2 70 8 C, after which they were incubated with antibodies specific for Hsp or viral components. The Hsp-specific MAbs (StressGen) ...
6
Functional Interactions of Human Immunodeficiency Virus Type 1 Integrase with Human and Yeast HSP60
... expressing HSP60 G432D (35) and the W303 a/ ␣ temperature-sensitive strain (Yep351) expressing both HSP60 G432D and SCS1, derived from the diploid yeast strain W303 a/␣, were used to study the in vivo ...
10
The ATPase activity of molecular chaperone HSP60 is inhibited by immunosuppressant mizoribine
... of HSP60/HSP10. HSP10 repeatedly bound and dissociated from HSP60 coupled with the ATP hydrolysis of ...When HSP60 is in a complex with HSP10, both HSP60 and HSP10 are resistant to the trypsin ...
10
Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance
... including HSP60 in mitochondria ...of HSP60 to stabilize mitochondrial proteins, promote mitochondrial protein biosynthesis and to prevent mitochondrial apop- tosis seems to be crucial for its protective ...
11
Human Hepatitis B Virus Polymerase Interacts with the Molecular Chaperonin Hsp60
... and Hsp60, the following experiments were ...and C indicate that the Hsp60 band appears only in the fraction originating from vFPolE-infected insect ...to Hsp60. If the binding of human HBV ...
7
CYTOTOXIC EFFECT OF ECLIPA EXTRACT ON BREAST TUMOR TARGETED TO Hsp60 DURING APOPTOSIS
... and Hsp60 siRNA were purchased from ...mouse Hsp60, GAPDH, and β-tubulin antibodies were purchased from Thermo-Fisher whereas, antihuman rabbit Hsp60, Cleaved PARP, Caspase-8, Caspase- 9, COX-IV, PDI ...
21
Schistosoma japonicum HSP60 derived peptide SJMHE1 suppresses delayed type hypersensitivity in a murine model
... The most important finding of the current study is that the administration of the parasite-derived immunomodu- latory molecule SJMHE1 from S. japonicum can inhibit DTH responses in a mouse model. SJMHE1 is composed of ...
11
Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma
... aberrant Hsp60 expression has been found in various types of cancers [15-17, ...the Hsp60 expression in ...that Hsp60 levels are increased in specimens of HCC patients with hepatitis C virus ...
14
Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease
... of Hsp60 on microglia requires the binding to specific ...whether Hsp60 could provoke microglial cell-activating properties similar to those previously reported for mac- rophages [39,40], we performed in ...
12
Gene expression profiling of whole blood cells supports a more efficient mitochondrial respiration in hypoxia-challenged gilthead sea bream (Sparus aurata)
... Mix (Bio-Rad, Hercules, CA, USA) and specific primers at a final concentration of 0.9 μM (Additional file 1: Table S1). The 96-well PCR-array layout was designed for the simultaneous profiling of a panel of 85 mito- ...
12
The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease
... longevity both in C. elegans and in mice (Houtkooper et al., 2013). Using the BXD isogenic genetic reference population of mice with a high level of genetic variability in their genome (Peirce et al., 2004), we ...
7
Specific Distribution within the Enterobacter cloacae Complex of Strains Isolated from Infected Orthopedic Implants
... the hsp60 gene showed that among the genetic clusters of the Enterobacter cloacae complex, clusters VI and VIII, but not cluster III, are predominantly associated with infections of orthopedic im- plants and, more ...
7
Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity
... It is established that key cellular processes, with distinctive func- tional roles, are involved in promoting disease progression in Barrett oesophagus. Some of these processes include inflammation, hypoxia and ...
13
Trypanosoma cruzi Discret Typing Units (TcII and TcVI) in samples of patients from two municipalities of the Jequitinhonha Valley, MG, Brazil, using two molecular typing strategies
... the typing confirmed: 125 bp (rDNA type I) for amplified products of 24Sα rDNA; 212 bp + 81 bp, characteristic of mitochondrial haplotype C lineage and 150 bp −157 bp for amplified products of intergenic spacer of ...
11
Antibody Binding Alters the Characteristics and Contents of Extracellular Vesicles Released by Histoplasma capsulatum
... The fungal species analyzed are from the phylum Ascomycota, and orthologue analyses demonstrate that they release common extracellular components to deliver diverse macromolecules to the extracellular space (13, 22). ...
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