HTLV-1
Effects of host restriction factors and the HTLV 1 subtype on susceptibility to HTLV 1 associated myelopathy/tropical spastic paraparesis
... First, we examined APOBEC3G, and the patients hav- ing rare variants tended to show more G-to-A mutations than those without rare variants. However, no signifi- cance differences were observed in the clinical states, ...
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Characteristic expression of HTLV 1 basic zipper factor (HBZ) transcripts in HTLV 1 provirus positive cells
... in HTLV-1 provirus-positive cells, the HBZ-SI and Tax mRNA loads in samples with a mixture of infected and non-infected cells were measured and then adjusted by dividing by the HTLV-I proviral ...
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Tuberculosis incidence in a cohort of individuals infected with human T lymphotropic virus type 1 (HTLV 1) in Salvador, Brazil
... with HTLV-1 was ...the HTLV-1 infected group and ...with HTLV-1 and 40 in the uninfected ...both HTLV-1 and ...with HTLV-1, with a mean time ...
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HSP90 Protects the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Oncoprotein from Proteasomal Degradation To Support NF-κB Activation and HTLV-1 Replication
... inhibiting HTLV-1 replication, 17-DMAG also potently suppresses NF- B activation and induces the apoptotic cell death of HTLV-1-transformed cell ...that HTLV-1-transformed ...
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ADAR1 enhances HTLV 1 and HTLV 2 replication through inhibition of PKR activity
... Figure 2 ADAR1 has a proviral effect on de novo HTLV-1 and HTLV-2 infection in T-lymphocytes. (A): Jurkat or PBLs were transfected either with 2.5 μ g of an ADAR1 or of a backbone vector, together ...
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Humoral immune response to HTLV 1 basic leucine zipper factor (HBZ) in HTLV 1 infected individuals
... for HTLV-1 Gag, Env and Tax among ATL subtypes [31], it is important to validate these observations with HBZ in a larger sample of ATL patients that includes the less common subtype, smoldering ...
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STLV 1 as a model for studying HTLV 1 infection
... To determine which simian species carry STLV-1, seroepidemiological studies were performed using kits that had been previously developed for the detection of anti-HTLV-1 human antibodies, as well as ...
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The Indinavir Derivate as a Novel Pharmacophore for Treatment of HTLV-1 Viral Infections
... while HTLV-1 protease 116 amino ...against HTLV-1 ...between HTLV-1 and HIV-1 proteases: first, presence of some unique amino acids, in the functional domains of ...
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Involvement of TORC2, a CREB co activator, in the in vivo specific transcriptional control of HTLV 1
... of HTLV-1 is controlled by CREB bind- ing to the enhancer sequence, which consists of three 21- bp direct repeats containing CREs in the ...the HTLV-1 ...of HTLV-1 in vivo, ...
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Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients
... diseases, HTLV-1 increased MMP- 3 gene expression (16, ...by HTLV-1 virus may affect the patients with coronary artery disease, our result was against this outcome and MMP-3 gene expression ...
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HTLV 1 Tax: centrosome amplification and cancer
... and HTLV-1 transformed ...protein 1), a protein involved in centrosome cohe- sion during the interphase of cell cycle [40], and was shown to be part of the centrosome ...
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EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV 1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV 1 infected individuals, irrespective of clinical statuses
... type 1 (HTLV-1) was the first human retrovirus identified as a causative agent of human diseases, including adult T-cell leukemia/lymph- oma (ATL) [1–3] and HTLV-1-associated ...
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Characterization and Sequencing of Prototypic Human T-Lymphotropic Virus Type 1 (HTLV-1) from an HTLV-1/2 Seroindeterminate Patient
... the HTLV-1 tax gene, a crucial factor for transactivation and tran- scription of other HTLV-1 genes, we performed RT-PCR for HTLV-1 ...other HTLV-1-infected cell ...
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The Receptor Complex Associated with Human T-Cell Lymphotropic Virus Type 3 (HTLV-3) Env-Mediated Binding and Entry Is Distinct from, but Overlaps with, the Receptor Complexes of HTLV-1 and HTLV-2
... 2. HTLV-3 SU binds to CD4 ⫹ and CD8 ⫹ T cells, dendritic cells, and B ...(A) HTLV-3 SU binding to CD4 ⫹ T ...the HTLV-3 SU protein fused to rabbit IgG (HTSU3-IgG/pCMV-Env) or, as a control, a similar ...
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Comparative virology of HTLV 1 and HTLV 2
... in HTLV-1 cellular transformation/pathogenesis [56, 57]. Tax-1 and Tax-2 differentially interact with the NF-κB pathway, which plays a role in the differential transforming activity in culture and ...
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Enhanced specificity of truncated transmembrane protein for serologic confirmation of human T cell lymphotropic virus type 1 (HTLV 1) and HTLV 2 infections by western blot (immunoblot) assay containing recombinant envelope glycoproteins
... type 1 (HTLV-1) (protein 21e) are capable of detecting antibodies in all individuals infected with HTLV-1 and ...recombinant HTLV type-specific proteins and a whole virus lysate ...
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SUV39H1 interacts with HTLV 1 Tax and abrogates Tax transactivation of HTLV 1 LTR
... after HTLV-1 infection where the viral gene is vigorously transcribed and abundant Tax protein presumably coex- ists with high levels of SUV39H1 protein induced by ...of HTLV-1 LTR and SUV39H1 ...
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The HTLV 1 Tax interactome
... phosphorylation to recruit coactivators [98,100]. Never- theless, recent reports indicate that Tax1 rather cooperates with phosphorylated CREB (pCREB) to induce transacti- vation [109,110]. High levels of pCREB are ...
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Molecular epidemiology, genetic variability and evolution of HTLV 1 with special emphasis on African genotypes
... the HTLV-1a genome, two open reading frames (ORFs) encode four accessory proteins: p12 is encoded by ORFI and can be cleaved into p8; p13 and p30 are encoded by ORFII and are obtained by alternative splicing ...of ...
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Immunovirological markers in HTLV 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
... plus-strand HTLV-1 transcription was detectable when PBMCs of HTLV-1 infected individu- als are cultured ex ...of HTLV-1 expression remains ...enhanced HTLV-1 ...
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