Human astrocytes
HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS
... HIV-infected astrocytes, Cx con- taining channels, including gap junctions and hemichannels, allow toxins from these few HIV-infected astrocytes to reach neighboring uninfected CNS cells [4, 7, 8, ...in ...
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Profiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry
... TNF and IL-1β significantly increased the secretion of all tested cytokines and chemokines apart from IL-10, consistently with previous studies reporting the TNF/ IL-1β-induced secretome in human astrocytes ...
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Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro inflammatory conditions in human astrocytes
... ments. Human astrocytes were pre-treated with inhibitors for 30 min followed by 18-h treatment with cytokines as indicated in the figure ...with human CX3CL1 ELISA kit according to the manufacturer’s ...
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The Effects of Radiofrequency Electromagnetic Field on Brain-Derived Neurotrophic Factor Protein Expression of Human Astrocytes
... In spite of numerous reports on the effects of EMF on cells, researchers reported conflicting results. Some researcher demonstrated positive effects of EMFs on cell proliferation [25,26]. In contrast, some researchers ...
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Fingolimod induces neuroprotective factors in human astrocytes
... on astrocytes Both primary human astrocytes and U373 astrocytoma cells expressed predominantly S1PR1 and S1PR3 (Additional file 6: Figure S4), consistent with the litera- ture [9, ...
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Variant-Specific Tropism of Human Herpesvirus 6 in Human Astrocytes
... tal astrocytes where HHV-6A (GS strain) was associated with a productive virus infection ...fetal astrocytes, though at a lower level than HHV-6A-infected cultures ...of astrocytes with HHV-6B, are ...
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Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease
... The excitotoxin quinolinic acid (QUIN) is synthesized through the kynurenine pathway (KP) by activated monocyte lineage cells. QUIN is likely to play a role in the pathogenesis of several major neuroinflammatory diseases ...
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Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.
... primary human fetal astrocytes, we show that exogenous HIV-1 Tat protein, which has been demonstrated to be released from infected cells, is associated with an increase in the binding of this transcription ...
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Uptake and mitochondrial dysfunction of alpha synuclein in human astrocytes, cortical neurons and fibroblasts
... The accumulation and aggregation of alpha-synuclein ( α -syn) in several tissue including the brain is a major pathological hallmark in Parkinson ’ s disease (PD). In this study, we show that α -syn can be taken up by ...
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Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
... in astrocytes exposed to FTY720 or S1P at 15 min, as previously reported in Durafourt et ...When astrocytes were incubated overnight (18 h) with an initial dose of FTY720, the intensity of pERK1/2 signaling ...
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Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes
... cells. Astrocytes treated with pFYT720 (1 μM) for 1 h at 37°C caused S1P1R redistribution to a peri-nuclear region as described above (Figure ...S1P1Rs, astrocytes treated with pFTY720 (1 μM) for 1 h at ...
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Human Immunodeficiency Virus Type 1 Induces Expression of Complement Factors in Human Astrocytes
... These results imply that complement might play a pivotal role in the HIV infection of the brain. Characteristics of HIV- affected brains are neuronal loss, reactive astrocytosis, and myelin pallor (9). The role of ...
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Cross-reactivity of anti-human immunodeficiency virus type 1 gp41 antibodies with human astrocytes and astrocytoma cell lines.
... 6262 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest An antigen expressed by astrocytes in human brain tissue and by various human astrocytoma cell lines was shown to cr[r] ...
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Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
... Overall, our data suggests a role for protein kinase CK2 in the neuroinflammatory response in AD. Although neuroinflammation in the brain of AD patients is consid- ered primarily beneficial, i.e. removing Aβ aggregates ...
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Human glial chimeric mice reveal astrocytic dependence of JC virus infection
... the human gliotropic JC virus (JCV). Due to the human-selective nature of the virus, there are no animal models available to investigate JCV ...engrafting human glial progenitor cells (GPCs) into ...
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Original Article MiR-433 functions as a tumor suppressor in glioma cells by regulating YAP1
... Normal human astrocytes HEB cells and human astrocytoma cell line U-251MG cells were pur- chased from ATCC (Rockville, MD, USA), and were cultured in complete medium RPMI-1640 (supplemented with 10% ...
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ApoE isoforms differentially regulates cleavage and secretion of BDNF
... primary human astrocytes. After 24 h, ApoE3 treated astrocytes secreted ...ApoE2-treated astrocytes, and ApoE2-treated astrocytes secreted 3-fold more mature-BDNF (m-BDNF) than ...
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2019_Patel.pdf
... Imipridones Elicits Unique Vulnerabilities in Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research 2018, 24:5392-406. [22] Sonoda Y, Ozawa T, Hirose Y, Aldape KD, ...
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Human derived neural progenitors functionally replace astrocytes in adult mice
... that human neural cells, espe- cially astrocytes derived from SOD1 mutant iPSCs impair neigh- boring neurons, leading to functional deficits in ...using astrocytes isolated from ALS trans- genic mice ...
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Neuroinflammatory astrocytes generated from cord blood-derived human induced pluripotent stem cells
... suggests human as- trocytes are morphologically, transcriptionally, and functionally distinct from those of ...rodents. Human as- trocytes are morphologically larger and more complex than their rodent ...
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