Human cancers
<p>OTUD4: A Potential Prognosis Biomarker for Multiple Human Cancers</p>
... many human cancers, such as but not limited to: the receptor tyrosine kinase inhibitor (TKI) imatinib in chronic myelogenous leukemia, 2 the anti-HER2 monoclo- nal antibody Herceptin in breast cancer, 3 the ...
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A systematic survey of HOX and TALE expression profiling in human cancers
... ABSTRACT HOX and TALE genes encode homeodomain (HD)-containing transcription factors that act in concert in different tissues to coordinate cell fates and morphogenesis throughout embryonic development. These two ...
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APOBEC3B, a molecular driver of mutagenesis in human cancers
... C → T transitions in multiple human cancers have been suggested to be caused by APOBEC3B. A uracil residue results from APOBEC3B cytosine deamina- tion can be excised by uracil DNA glycosylase and then ...
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Current implications of cyclophilins in human cancers
... Although human Cyps were identified about 25 years ago, their physiological and pathological roles have only been the focus of attention recently because of their possible involvement in diseases and ailments such ...
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Technical advances in global DNA methylation analysis in human cancers
... Prototypical abnormalities of genome-wide DNA methylation constitute the most widely investigated epigenetic mechanism in human cancers. Errors in the cellular machinery to faithfully replicate the global ...
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Modelling mutational landscapes of human cancers in vitro
... in human datasets and immortalised MEF lines includes: (a) the global distribution of mutation types, (b) the accumulation of mutations on the non-tran- scribed strand (strand bias) for treatments with carcinogens ...
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Current understanding of mdig/MINA in human cancers
... In human multiple myeloma cells, we also found overexpression of mdig/ MINA is associated with disease onset, progression and ...to human cancers (Figure 5), developing therapeutic chemicals or ...
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Identification and manipulation of tumor associated macrophages in human cancers
... Macrophages play an important role in tumors. Depend- ing on the mode of activation, they may promote tumor growth and suppress local immunity or attack tumor cells and sustain tumor immunity. Immunotherapeutic ...
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Driver fusions and their implications in the development and treatment of human cancers
... Highlights d Highly recurrent fusions were found in prostate, bladder, breast, and lung cancers d Expression increased in oncogene fusions but decreased in tumor suppressor genes d Thyro[r] ...
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The NF1 somatic mutational landscape in sporadic human cancers
... A375 human melanoma cell lines, Maertens and colleagues have shown that resistance to treatment was enhanced by fur- ther suppression of NF1 by small hairpin RNA ...
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Integrated genomic analysis of mitochondrial RNA processing in human cancers
... We evaluated the magnitude and significance of differ- ential expression of transcripts of nuclear-encoded mito- chondrial RNA-binding proteins [33] using analysis of variance and Bonferroni thresholds to infer ...
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A Clinical Overview of Centrosome Amplification in Human Cancers
... Support for CA contributing to genomic insta- bility during prostate cancer development has been derived from data showing the increased frequency of centrosome abnormalities progressing from prostate intraepithelial ...
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LINE-1 ORF2p expression is nearly imperceptible in human cancers
... ORF2p is strictly required for retrotransposition [30], and so its expression in human malignancies can be in- ferred. Whether the protein can be directly detected has been a matter of some debate. In experimental ...
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The landscape of metastatic progression patterns across major human cancers
... breast cancers tended to metastasize to liver, bones, non- regional lymph nodes, lung and pleura (80%, 79%, 60%, 54% and 52%), prostate cancers were predominantly associated with metastatic spread to the ...
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Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis
... multiple human tumors, (2) detected the expression levels of SNHG20 in cancer tissue, (3) divided the patients into dichotomous groups according to the specific criteria for SNHG20 expression levels, (4) reported ...
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Epigenetic regulation of mucin genes in human cancers
... in human cancer cell lines (breast, lung, pancreas, and colon) to determine the methylation status of CpG islands in the MUC17 5′-flanking region (−620 to +209) (Kitamoto et ...
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The role of cullin4B in human cancers
... in human genome, including cullin1, cullin2, cul- lin3, cullin4A, cullin4B, cullin5, cullin7 and PARC, also known cullin9 ...with human diseases, including cancer ...
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Multiple biological functions of transcription factor 21 in the development of various cancers
... of human cancers and exerts a wide variety of functions, including the regulation of epithelial–mesenchymal transition, invasion, metastasis, cell cycle, and ...various cancers, revealing the ...
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Subunits of human condensins are potential therapeutic targets for cancers
... Secondly, two non-SMC subunits of condensin I have been demonstrated to be dysregulated or mutated in human cancers, and therefore could be potential novel therapeutic targets. For example, NCAPH (i.e. ...
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Diagnostic value of circulating miR-21: An update meta-analysis in various cancers and validation in endometrial cancer
... 0.82 respectively, which were much higher than that of traditional serum-based cancer biomarkers. In this meta-analysis, the overall PLR was 4.3, which suggests that the possibility of developing cancer for potential ...
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