human carbonic anhydrase II
Organization of the Mouse and Human Carbonic Anhydrase II Genes a
... Mouse C A I1 Genomic Clones Genomic sequences hybridizing to the labeled pMCAII probe were isolated from both cosmid and lambda genomic libraries.. Cosmid Clone A6.[r] ...
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In vitro inhibition of purified human carbonic anhydrase I and II by novel fluorene derivatives
... and II purified from human erythrocytes and structure–activity relationships were ...and II isoenzyme ...and II in the same way or that the fluorenyl moi- ety interacted with the hydrophobic ...
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Novel chloroquinoline derivatives incorporating biologically active benzenesulfonamide moiety: synthesis, cytotoxic activity and molecular docking
... (2014) Carbonic anhydrase inhibitors: synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel ...
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Correction of renal tubular acidosis in carbonic anhydrase II deficient mice with gene therapy
... cytomegalovirus (CMV) promoter/enhancer as an expression cassette to drive human CAII cDNA, into the renal pelvis of CAII-deficient mice results in expression of CAII in the kidney. The levels of both the CAII ...
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Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance
... tested in vitro for activity against three pathogenic yeast isolates, Candida albicans, Candida parapsilosis and Candida krusei. The activity of compounds 1, 2 and 4 were comparable to that of the reference compound ...
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Characterization of the carbonic anhydrase isozymes of zea mays
... Alpha-CAs have been identified and characterized in animals, insects, algae, the nematode Caenorhabditis elegans, bacteria such as Helicobacter pylori, and other prokaryotes. An alpha-CA gene in C. elegans encodes two CA ...
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Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization
... Carbonic anhydrase IV (CA IV) is a glycosylphosphatidylinositol-linked isozyme previously identified on the surface of renal tubular epithelium and certain populations of vascular ...CA II mRNA was ...
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Biochemical and developmental characterization of carbonic anhydrase II from chicken erythrocytes
... Kondo et al. [22] reported that the concentration of CA- II in human erythrocytes was approximately 3.2 mg/g of Hb and that of CA-I was approximately 14 mg/g of Hb. Although little variation in the levels ...
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Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan β-Lactam Derivatives
... Abstract: β-Lactams are pharmacologically important compounds because of their various biological uses, including antibiotic and so on. β-Lactams were synthesized from benzylidene-inden derivatives and acetoxyacetyl ...
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Effect of Hyperglycemia on Erythrocyte Carbonic Anhydrase and Lactic Acid in Type II Diabetic Subjects
... Human erythrocytes are continuously being exposed to glucose in plasma during their circulatory life span of 120 days. The erythrocytes and their membranes have always been objects of studies as they play an ...
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The different modes of docking of a series of benzenesulfonamides and tetrafluorobenzenesulfonamides to the carbonic anhydrase isoform II
... human CAs belong to the α -class of this family. Up today, fifteen isoforms have been described. Only twelve of them are catalytically active (I–IV, VA, VB, VI, VII, IX, and XII–XIV). They are widely distributed ...
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Carbonic Anhydrase II Deficiency Syndrome: Recessive Osteopetrosis With Renal Tubular Acidosis and Cerebral Calcification
... Sly WS, Whyte MP, Sundaram V, et al: Carbonic anhydrase II deficiency in 12 families with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calci[r] ...
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The Value of Inherited Deficiencies of Human Carbonic Anhydrase Isozymes in Understanding Their Cellular Roles a
... Renal Tubular Acidosis The renal tubular acidosis that has been reported for some of the CA I1 deficient individuals seems to have both a proximal and distal component.38 Since CA I1 is [r] ...
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Original Article Oncogenic roles of carbonic anhydrase IX in human nasopharyngeal carcinoma
... Abstract: Carbonic anhydrase IX (CA IX), a hypoxia-inducible protein in tumors, has been shown to be valuable for the prognosis of nasopharyngeal carcinoma ...
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Carbonic anhydrase in the adult mosquito midgut
... quantitated CA content in the anterior and posterior midgut of adult males and females from these species using the 18O isotope exchange method coupled to mass Key words: mosquito, carbo[r] ...
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Characterisation of carbonic anhydrase in the symbiotic dinoflagellate Symbiodinium
... Carbon dioxide and light regulation of promoters controlling the expression of mitochondrial carbonic anhydrase in Chlamydomonas reinhardtii.. Evolutionary analysis of orthologous cDNA s[r] ...
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Carbonic anhydrase (acetazolamide sensitive esterase) activity in the blood, gill and kidney of the thermally acclimated rainbow trout, Salmo gairdneri
... Comparison of the specific activities of carbonic anhydrase and Na+/K+ ATPase McCarty & Houston, 1977 in the gills and kidneys of rainbow trout also suggests that the ratio of carbonic a[r] ...
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Synthesis, Structure Analysis and Antibacterial Activity of New Potent Sulfonamide Derivatives
... The demand for novel chemotherapeutic antibacterial remains attractive in the field of medicinal chemistry. The discovery of sulfonamides as antibacterial in the early 30s was the beginning of the most fascinating era of ...
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Characterization of the carbonic anhydrase isozymes of zea mays
... ClustalW alignment of the deduced amino acid sequences of Repeat A of the maize CA2 cDNA sequence and the rice chloroplastic CA not including the chloroplast transit peptide.. Alignment [r] ...
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Spontaneous luminal disequilibrium pH in S3 proximal tubules Role in ammonia and bicarbonate transport
... following the addition of carbonic anhydrase (0.1 mg/ml) to the perfusate. In S3 tubules perfused and bathed in 4 mM total ammonia, luminal total ammonia rose from 4.08 +/- 0.05 mM (perfusate) to 4.95 +/- ...
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