Human cord blood cell
Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cells
... Common cell culture techniques enable the billion-fold expansion of hMSCs [19] but also cause the gradual loss of their primi- tive characteristics and self-renewal ...
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Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells
... high levels of DLL4 compared to HuVECs-E4orf1-GFP. In view of this, we speculated that HuAECs-E4orf1-GFP might support ex vivo HSPC expansion through Notch signaling activation. For further verification, a specific Notch ...
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Umbilical cord blood-derived mesenchymal stem cells consist of a unique population of progenitors co-expressing mesenchymal stem cell and neuronal markers capable of instantaneous neuronal differentiation
... include cell-based therapy to replenish degenerated neurons, cardiac cells, muscle cells, chondrocytes, and so ...of human umbilical cord blood (hUCB)-MSCs was found to be feasible treatment ...
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The TEL AML1 leukemia fusion gene dysregulates the TGF β pathway in early B lineage progenitor cells
... B cell progenitor cell line expressing inducible TEL-AML1 proliferates at a slower rate than parent cells but is more resistant to further inhibition of proliferation by ...in human cord ...
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Circular Epstein-Barr virus genomes of reduced size in a human lymphoid cell line of infectious mononucleosis origin.
... Second, the human umbilical cord blood leukocytes recently transformed with EBV studied here contain circular virus DNA molecules, but in contrast to other EBVcarrying cell lines investi[r] ...
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Effect of Human Parathyroid Hormone on Hematopoietic Progenitor Cells in NOD/SCID Mice Co Transplanted with Human Cord Blood Mononuclear Cells and Mesenchymal Stem Cells
... of cell surface antigens Both the femorae and tibiae were removed after eauthana- ...red blood cell (RBC) lysis (BD Pharmingen, San Diago, CA, USA), the suspended cells were stained with ...
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Endothelium targeted human Delta like 1 enhances the regeneration and homing of human cord blood stem and progenitor cells
... stem cell niches [25]. However, the in vivo roles of human D1R (hD1R) on hematologic recovery and the engraftment of donor cells in HSCT were not explored in ...the human Dll1 and a RGD ...
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Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2locus
... leukemic cell clones from these patients revealed that the murine leukemia virus (MLV) vector had integrated proximal to the promoter of an oncogene involved in T-cell acute lym- phoblastic leukemia, ...
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Human Herpesvirus 6B Induces Cell Cycle Arrest Concomitant with p53 Phosphorylation and Accumulation in T Cells
... as cord blood mononu- clear cells and blood cells from infants with HHV-6 infections (16, ...and cell type-specific factors are important for the decision to undergo ...favors cell ...
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Intraarterial transplantation of human umbilical cord blood mononuclear cells is more efficacious and safer compared with umbilical cord mesenchymal stromal cells in a rodent stroke model
... cbMNC-treated rats showed early (within 7 days) recovery in the grid-walk test. This was likely attributable to the significant improvement seen in both contralateral fore- limb and hindlimb deficits in this group. ...
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Characterization of the suppressor cell activity in human cord blood lymphocytes
... suppressor cell subpopulation has not yet been ...on human cord blood cells as defined by monoclonal antibodies and to characterize cord blood mononuclear cells that suppress in ...
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B Cell Differentiation and Immunoregulatory T Cell Function in Human Cord Blood Lymphocytes
... from human newborns was evaluated using a reverse hemolytic plaque assay to detect immunoglobulin-secreting cells generated in in vitro cultures stimulated with pokeweed mitogen (PWM), a T cell-dependent ...
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Cord blood cell-derived iPSCs as a new candidate for chondrogenic differentiation and cartilage regeneration
... established cord blood banking system around the world, CBMCs are widely ...of cord blood banks into hiPSC banks for allo- geneic regenerative medical treatment holds tremendous potential and ...
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Value of Screening Umbilical Cord Blood for Hemoglobinopathy
... Only four false-negative results were detected in which sickle cell disease was diagnosed at a later age when not suspected by the cord blood study: two infants with cord blood phenotype[r] ...
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Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application
... mast cell granule stimulates UCB-MSCs to ameliorate the symp- toms of experimental AD more efficiently via upregulat- ing immunomodulation and tissue regeneration ...
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First Report of Autologous Cord Blood Transplantation in the Treatment of a Child With Leukemia
... ing for private UCB collection and storage, there will certainly be more cases of autologous UCB transplanta- tion in the future, which may answer some of the ques- tions regarding the value of autologous cord ...
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Genetic and Environmental Influences on Human Cord Blood Leptin Concentration
... of blood pressure and heart rate that can be monitored longitudinally, the timing of overall high values recurring each day tends to change from day to day early after birth to occur eventually in the afternoon, ...
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Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri.
... protein of subgroup C virus strains (StpC), a phosphoprotein which associates with cellular Ras. stpC causes oncogenic transformation of rodent fibroblasts and epithelial cells as an isolated gene under heterologous ...
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Functional characterisation of bone marrow stromal cells and their responses to leukaemia therapy
... 1994 Phenotypic Analysis and Characterization of CD34+ Cells from Normal Human Bone Marrow, Cord Blood, Peripheral Blood, and Mobilized Peripheral Blood from Patients Undergoing Autologo[r] ...
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Benefits of Delayed Cord Clamping in Red Blood Cell Alloimmunization
... results with a reduction of early red blood cell transfusion in the DCC group compared with an historical cohort (13.3% vs 33%) (odds ratio 0.11, 0.03–0.41). In healthy newborns, after delayed clamping, it ...
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