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Human epidermal growth factor receptor

The coexpression  and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study

The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study

... fibroblast growth factor receptor 2 (FGFR2), and human epidermal growth factor receptor 2 (HER2) in human GC and their clinical significance in clinical ...

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Prognostic significance of Human epidermal growth factor receptor 2 expression in patients with resectable gastric adenocarcinoma

Prognostic significance of Human epidermal growth factor receptor 2 expression in patients with resectable gastric adenocarcinoma

... Human epidermal growth factor receptor 2 (HER2), a target used in breast cancer treatment, is the second member of the epidermal growth factor receptor ...

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PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients

PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients

... Sufficient tumor material was available for 739 patients, who did not differ in prognostic factors from the total group (see Additional file 1: Table S1). After revision of ERα status as assessed with ...

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Impact of country of birth on genetic testing of metastatic lung adenocarcinomas in France : African women exhibit a mutational spectrum more similar to Asians than to Caucasians

Impact of country of birth on genetic testing of metastatic lung adenocarcinomas in France : African women exhibit a mutational spectrum more similar to Asians than to Caucasians

... Abbreviations NSCLC: non-small cell lung cancer; EGFR: epidermal growth factor receptor; ERBB2: human epidermal growth factor receptor 2 avian erythroblastosis oncogene B2 homolog; KRAS:[r] ...

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The progress of targeted therapy in advanced gastric cancer

The progress of targeted therapy in advanced gastric cancer

... Approximately one million people are diagnosed each year with gastric cancer, making it the fourth most com- mon cancer and the second leading cause of cancer re- lated death worldwide with an estimated 800,000 deaths ...

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Triple-negative breast cancer: new perspectives for targeted therapies

Triple-negative breast cancer: new perspectives for targeted therapies

... like, human epidermal growth factor receptor 2, and ...and human epidermal growth factor receptor ...

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6100.pdf

6100.pdf

... EGFR(epidermal growth factor receptor) and the related HER-2 (human epidermal growth factor receptor 2) associated with breast cancer has allowed for the ...

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Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis

Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis

... the epidermal growth factor receptor (EGFR). Human epidermal growth factor receptor (HER)2 and EGFR have attracted much attention in the medical literature ...

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New developments in the treatment of HER2-positive breast cancer

New developments in the treatment of HER2-positive breast cancer

... the human epidermal growth factor receptor-2 (HER2) tyrosine ...of epidermal growth factor receptor and HER2 tyrosine kinases, and is approved for ...

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Role of lapatinib in the first-line treatment of patients with metastatic breast cancer

Role of lapatinib in the first-line treatment of patients with metastatic breast cancer

... Abstract: Lapatinib is a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth factor receptor 2 ...

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Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer

Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer

... of human epidermal growth factor receptor (HER)2 and other receptor tyrosine ...estrogen receptor (ER)+ breast cancer cells, PI3K activation promotes estrogen- dependent ...

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Metastasizing Maxillary Ameloblastoma: Report of a Case with Molecular Characterization

Metastasizing Maxillary Ameloblastoma: Report of a Case with Molecular Characterization

... a human epidermal growth factor receptor belonging to the same family of EGFR and its protein overexpression has been found in several carcinomas ...

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Prognostic Implications of ER, PR and HER2/Neu Protein Expression in a Cohort of Breast Carcinoma

Prognostic Implications of ER, PR and HER2/Neu Protein Expression in a Cohort of Breast Carcinoma

... The study had 29 patients (31.52%) with node positive disease at the time of presentation. 63 (68.48%) patients were free of nodal involvement at the time of the diagnosis of breast carcinoma. 6 of the node positive ...

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In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features

In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features

... Background: Epidermal growth factor receptor (EGFR) is an attractive therapeutic target for a number of human tumors including non-small cell lung cancer ...

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Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

... We performed differential expression analysis between the pretreatment biopsy (T1) and the surgical specimen (TS) to identify genes with significantly altered expres- sion in residual tumors. The results revealed the ...

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Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers

Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers

... Primary malignant bone tumours (bone sarcomas) and bone metastases (from breast, prostate carcinomas, etc.) are charac- terised by their ability to dysregulate their micro-environment and especially the balance between ...

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Does consuming isoflavones reduce or increase breast cancer risk?

Does consuming isoflavones reduce or increase breast cancer risk?

... cell growth and migration by dynamic activation of cytoskeleton remodeling in the presence of ERα only ...cell growth were downregulated, whereas cell cycle arrest and apoptosis factors were ...

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EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis

EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis

... We performed a systematic search of PubMed, EMBASE, The Cochrane Library, Chinese Biomedical Literature Database, and Wanfang Data from inception to 22 Novem- ber 2010. The detailed search strategy was described in the ...

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Design, Synthesis and Anticancer Screening of Novel Piperidine  ydroxamate as HDAC Inhibitors.

Design, Synthesis and Anticancer Screening of Novel Piperidine ydroxamate as HDAC Inhibitors.

... New York, 2008) for the docking simulations. These simulations were performed using the X-ray crystal structure of the human HDAC 8 complexed with SAHA (PDB ID: 1T69). All the water molecules in the crystal ...

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Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis

Prognostic value of <em>EGFR</em> and <em>KRAS</em> in resected non-small cell lung cancer: a systematic review and meta-analysis

... of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with ...mal growth factor receptor gene is not a prognostic factor for ...

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