human hepatic stellate cell
Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis
... any cell contamination, we detected cell chaperone Calnexin in iPSC-EVs and in cell lysates, as reported previously ...in cell lysates but not in the EV sample, indicating that iPSC-EV samples ...
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Hepatic stellate cells in liver development, regeneration, and cancer
... studying hepatic stellate cell–HCC interactions in transgenic mouse models of HCC has been somewhat limited, with the notable exception of the PDGF-C transgenic mouse ...express human PDGF-C, ...
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Mitochondrial uncouplers inhibit hepatic stellate cell activation
... of human and mouse HSC activation such as α-SMA expression and prolifera- tion are inhibited by chemical mitochondrial ...different cell lines, although the mechanism is still not fully understood ...
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Original Article miR-144 regulates transforming growth factor-β1 iduced hepatic stellate cell activation in human fibrotic liver
... cells and sinusoidal endothelial cells triggers apoptosis of hepatocytes, further inducing acti- vation and recruitment of inflammatory cells into injured liver and differentiation of liver resi- dent cells, such as HSC ...
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Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling
... clonorchiasis. Cell proliferation was detected by methyl thiazolyltetrazolium (MTT) assay when LX-2 cells were incubated with 50 μg/ml of CsESPs ...of hepatic fibrosis ...cause cell death for both ...
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PubMedCentral-PMC5175173.pdf
... autologous human immune and liver cells, human liver and blood samples and cell culture models of monocyte/macrophage and/or hepatic stellate cell ...activated human ...
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Hepatic stellate cells: central modulators of hepatic carcinogenesis
... HCC cell lines induced by TGF-β1 and epidermal growth factor (EGF) [58, ...HepG2 cell migration ...HCC cell lines Dong et ...in human HCC tissues and further assessment of it’s ...
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HNE interacts directly with JNK isoforms in human hepatic stellate cells
... in hepatic regeneration ...liver cell type, the data herein reported indicate a possible additional role for JNK in the development of liver fibrogenesis, and pro- vide a mechanism of action for the ...
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Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation
... analysis. Cell numbers and via- bility were evaluated using microscopy and the trypan blue exclusion assay, ...the Cell Counting Kit-8 (CCK-8; Sigma-Aldrich, ...
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PubMedCentral-PMC4992517.pdf
... of hepatic stellate cells (HSCs) represent a key aspect of fibrogenesis and are associated with progressive reduction of HSC ...in cell culture, which was consistent with the increase in apoptosis ...
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Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
... (12), stellate cell activation, and liver fibrosis (18, 19) observed in human liver ...(b) hepatic inflam- mation, and (c) hepatic ...and hepatic fibrogenesis during ...of ...
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Growth inhibitory properties of endothelin 1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate mediated pathway Inhibition of both extracellular signal regulated kinase and c Jun kinase and upregulation of endothelin B receptors
... in cell prolifera- tion (26, ...to cell proliferation (33–35), cell transformation (48, 49), and apoptosis (50, ...selected cell types, either positively, as shown with angiotensin II (47), ...
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hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
... between hepatic inflammation and hepatic fibrosis in fibrotic liver disease ...of human-induced pluripotent stem cell-derived EVs reduces development of fibrosis and TGF-β1- induced HSC ...
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Hepatoprotective leads from plants
... oxidative hepatic injury by improving hepatic antioxidant status (Sayed-Ahmed et ...induced hepatic fibrosis and inflammation in mice were attenuated by thymoquinone through suppression of protein ...
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Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway
... Samples of liver tissue were made into buffered formalin (10%) and embedded in paraffin. The 4 uM sections were deparaffinized and hydrated by gradient ethanol, cooked in a pressure cooker for ten minutes in 25 mM citrate ...
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Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies
... obtained in a chronic CCl 4 model, even when an advanced stage of micronodular cirrhosis was obtained after 12 weeks of administration of CCl 4 . Indeed, 1 year after the cessation of administration of CCl 4 , ...
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Mac the knife? Macrophages– the double edged sword of hepatic fibrosis
... activated stellate cells and/or myofibroblasts? Dur- ing fibrosis progression, it is believed that macrophages are likely to promote acti- vation of stellate cells through release of paracrine factors, ...
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Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities
... fulminant hepatic fail- ure that could be used to study hepatocyte regeneration and liver disease development and facilitate in vivo hu- man immature hepatocyte differentiation; it also has the potential for ...
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Original Article Establishment and characterization of an immortalized rat hepatic stellate cell line
... It is well established that cytokines play a key role in HSC activation. TGF-β 1 and PDGF are the two major cytokines involved in hepatic fibrosis [1, 30]. TGF-β 1 appears to play a central role in the cytokine ...
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Effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with Liver Cirrhosis
... of hepatic better than fluvastatin (lukisvaya et al, ...of hepatic cells stelat, reduced collagen deposition, and decrease the degree of liver fibrosis in murine models of cirrhosis (Yang et al, ...
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