Human Herpesvirus-6
Real Time Quantitative PCR for Human Herpesvirus 6 DNA
... Human herpesvirus 6 (HHV-6) is a ubiquitous infectious agent isolated for the first time in 1986 from patients with lymphoproliferative disorders ...the human population (30), with ...
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Human Herpesvirus 6 Variant A but Not Variant B Induces Fusion from Without in a Variety of Human Cells through a Human Herpesvirus 6 Entry Receptor, CD46
... Human herpesvirus 6 (HHV-6) is a lymphotropic betaherpesvirus that productively infects T cells and ...diverse human cells but HHV-6B did ...
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Variant-Specific Tropism of Human Herpesvirus 6 in Human Astrocytes
... virus, human herpesvirus 6 (HHV-6) is highly ...in human progenitor-derived astrocytes (HPDA) and monitored infected cell cultures for cytopathic effect (CPE), intra- and extracellular ...
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Frequent Detection of the Human Herpesvirus 6 Specific Genomes in the Livers of Children with Various Liver Diseases
... of human herpesvirus 6 (HHV-6) infection of the liver in children with a variety of liver diseases and to evaluate the role of HHV-6 infection in pediatric patients with prolonged non-B ...
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Comparison of the Complete DNA Sequences of Human Herpesvirus 6 Variants A and B
... Human herpesvirus 6 (HHV-6), which belongs to the betaherpesvirus subfamily and infects mainly T cells in vitro, causes acute and latent ...
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Identification of Human Herpesvirus 6 Latency-Associated Transcripts
... dilution. Representative data are shown in Fig. 6A. As a con- trol MT-4 cells were infected with HHV-6, and these cells were also diluted. RNA isolated from each sample tube was evaluated by double-nested RT-PCR ...
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The simultaneous presence and expression of human hepatitis C virus (HCV), human herpesvirus 6 (HHV 6), and human immunodeficiency virus 1 (HIV 1) in a single human T cell
... As a control, we infected macrophages obtained from cord blood cells with HHV-6A (K3) or both HHV-6A and HIV- 1 (K4). We were able to show infection of these cells by each virus (Figure 3A, Lane 5; Figure 3E, Lanes 5 and ...
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Pathogenic Effects of Human Herpesvirus 6 in Human Lymphoid Tissue Ex Vivo
... in human lymphoid tissue, where T lymphocytes were found to be the predominant target cells for both HHV-6A and -6B repli- cation, while other cell types were minimally, if at all, ...
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Coinfection with human herpesvirus 6 variants A and B in lung tissue
... All 10 of the previously characterized HHV-6 isolates were successfully detected with the SIE-1/2 (variant-common) primer set and the SIE-Com probe. SIE-1/2 PCR products from three variant A isolates (U1102, SIE, ...
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Development of a Human Herpesvirus 6 Species Specific Immunoblotting Assay
... H uman herpesvirus 6 (HHV-6) is classified as two distinct vi- rus species, designated HHV-6A and HHV-6B (2, 3, 20). Since the overall nucleotide sequence identity between the virus species is 90% ...
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Infection of primary human fetal astrocytes by human herpesvirus 6.
... Human herpesvirus 6 (HHV-6) is a recently discovered lym- photropic betaherpesvirus (3) which has been identified as the etiologic agent for exanthem subitum (roseola) (35) and as a major ...
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Cloning, expression and characterization of the proteinase from human herpesvirus 6.
... with human herpesvirus 6 (HHV-6) frequently occurs early in childhood and appears to result in the mild disease exanthema subitum ...and human immunodeficiency virus (HIV) has led to ...
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Signal Transduction by Human Herpesvirus 8 Viral Interleukin-6 (vIL-6) Is Modulated by the Nonsignaling gp80 Subunit of the IL-6 Receptor Complex and Is Distinct from Signaling Induced by Human IL-6
... binding properties and functional interactions with gp130. (A) Com- parison of vIL-6(R189L) with wild-type vIL-6 with respect to its abil- ities to induce gp130:gp130 (1) and gp80:gp130 (2) complexing and ...
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Recognition of a Novel Stage of Betaherpesvirus Latency in Human Herpesvirus 6
... This in vivo study indicated that the expression level of H6LTs might be increased in the period shortly preceding viral reactivation. To investigate the regulation of H6LTs, latently infected macrophages were stimulated ...
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Transcriptional Regulation of the Interleukin-6 Gene of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)
... Rta activates the vIL-6 promoter in a reporter system. Since Rta activated the expression of the vIL-6 gene from the en- dogenous viral genome (Fig. 1), we further investigated the mechanism by which Rta ...
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Human Herpesvirus 6B Induces Cell Cycle Arrest Concomitant with p53 Phosphorylation and Accumulation in T Cells
... Previously, HHV-6B was shown to induce apoptosis (16, 17, 31). However, our findings are not in conflict with those of an initial report (17) in which apoptosis was found to be enhanced by extracellular factors (tumor ...
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The Role of Human Herpesvirus Type 6 (HHV 6) in Convulsions Seen in Children at Korle Bu Teaching Hospital, Accra
... Studies done elsewhere showed that between 9% - 35% of convulsions are complex [22] [27] [28]. Kwong et al., and Chung et al., in their studies had 15% and 16% of their study subjects with complex convulsions re- ...
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CD4 Promoter Transactivation by Human Herpesvirus 6
... HHV-6 has been associated with the transactivation of sev- eral viral promoters, including those Epstein-Barr virus (12) and HIV (8, 15, 19, 50). The present study indicates that HHV-6 can also efficiently ...
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Human CD4+ T Cell Response to Human Herpesvirus 6
... to 6 peptides), we observed that for some pools elic- iting positive responses we were not able to identify individual peptides that met our criteria for a positive response ...from 6 donors, including the ...
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Induction of T-cell apoptosis by human herpesvirus 6.
... DNA fragmentation of HHV-6-inoculated cells untreated and treated with TNF- a . We next addressed the question of whether apoptosis is induced in T cells by HHV-6 infection and performed agarose gel ...
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