Human Leukocyte Antigen complex
Epigenome-wide and transcriptome-wide analyses reveal gestational diabetes is associated with alterations in the human leukocyte antigen complex
... Affymetrix Human Transcriptome Array ...histocompatibility complex (MHC) region on chromosome 6, represented by mul- tiple haplotypes on the ...this complex encodes genes involved in antigen ...
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Persistent Antigens Hypothesis: The Human Leukocyte Antigen (HLA) Connection
... Histocompatibility Complex (MHC) of chromosome 6, HLA genes code for glycoproteins that exist on the surface of most cells in order to facilitate immune surveillance and initiate an immune response to eliminate ...
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Spatial analyzes of HLA data in Rio Grande do Sul, south Brazil: genetic structure and possible correlation with autoimmune diseases
... histocompatibility complex; HLA: Human leukocyte antigen; HSCT: hematopoietic stem cell transplantation; AD: autoimmune diseases; RA: Rheumatoid arthritis; GIS: geographic information system; ...
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Significant Associations of the rs3104413 Single-nucleotide Polymorphism in the HLA Region with Type 1 Diabetes
... histocompatibility complex gene and DQ & DR genes have the most impact [5]. The human leukocyte antigen (HLA) which is a genetic region on chromosome ...
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Functional disruption of human leukocyte antigen II in human embryonic stem cell
... regulatory complex consists of three RFX factors (RFXAP, RFX5, RFXANK) and CIITA [14, ...This complex regulates not only the genes encod- ing classical HLA II molecules (HLA-DP, HLA-DQ and HLA-DR) but also ...
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Tri-Allelic Human Leukocyte Antigen (HLA) Protection Against Dementia
... Histocompatibility Complex (MHC) of chromosome 6, code for cell-surface glycoproteins that facilitate the elimination of foreign antigens and, therefore, play a critical role in host ...to antigen ...
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Neuropathology of SUDEPRole of inflammation, blood-brain barrier impairment, and hypoxia
... pre-Bötzinger complex and nucleus ...and human leukocyte antigen–antigen D related (HLA-DR) would be more globally upregulated in control regions and in key autonomic-regulatory ...
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THE PROFILE OF HUMAN LEUKOCYTE ANTIGEN CLASS I IN PATIENTS WITH SCHIZOPHRENIA
... a complex, chronic mental health disorder characterized by a spectrum of symptoms, including delusions, hallucinations, disorganized speech or behavior and impaired cognitive ...of Human Leukocyte ...
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Evolution of the levels of human leukocyte antigen G (HLA G) in Beninese infant during the first year of life in a malaria endemic area: using latent class analysis
... The present analysis, confirms these results, and pro- vides new understanding by identifying new determi- nants of sHLA-G evolution. Indeed, although in the first study, the level of sHLA-G increased the risk of ...
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The relationship between human leukocyte antigen DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population
... persistent infection through a variety of complex mecha- nisms [28]. Furthermore, the epitopes of CD4+ T-cell are highly promiscuous and can often be restricted by a variety of different HLA class II molecules ...
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Activities of stromal and immune cells in HPV-related cancers
... HLA: Human leukocyte antigen; HLA-DR: Human leukocyte antigen D related; HNSCC: Head and neck squamous cell carcinoma; HPV: Human Papillomavirus; hrHPV: High risk HPV; ...
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The biomarkers of immune dysregulation and inflammation response in Parkinson disease
... histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration, especially in dopaminergic ...the human leukocyte antigen genes ...
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Association of human leukocyte antigen-DRB haplotype in multiple sclerosis population of Khuzestan, Iran
... 6. Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, et al. Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature 2006; 443(7111): 574-7. 7. Krogsgaard M, Wucherpfennig ...
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The role of neoantigen in immune checkpoint blockade therapy
... APC: antigen presentation cell; CTLA- 4: cytotoxic T lymphocyte-associated antigen-4; ERBB2IP: erbb2 interacting protein; HLA: human leukocyte antigen; Lama4: Laminin alpha subunit 4; ...
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Expression of Human Leukocyte Antigen G is associated with Prognosis in Nasopharyngeal Carcinoma
... Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) class Ib antigen. In non-pathological situa- tions, HLA-G expression is restricted to the ...
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Enhanced presentation of MHC class Ia, Ib and class II restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy
... loaded human and murine dendritic cells (DC) with the peptide-containing nanoparticles and determined their ability to present the encapsulated peptide antigens and to induce tumor-specific cytotoxic T lymphocytes ...
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Studies with human leukocyte lysosomes Evidence for antilysosome antibodies in lupus erythematosus and for the presence of lysosomal antigen in inflammatory diseases
... lysosomal antigen in SLE and related disorders was also ...to human lysosomes in immunodiffusion, a soluble lysosomal component, apparently distinct from the sedimentable (membrane-associated) ...
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Investigation of Human Leukocyte Antigen (HLA) Class I and II Alleles and Hepatitis C Virus (HCV) Genotypes in Patients Infected with HCV
... Studies have reported the effect of many factors in disease development such as viral factors including viral genotype and viral load, and host factors including age, sex, environment, associated medical conditions as ...
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Giant cell arteritis: pathogenic mechanisms and new potential therapeutic targets
... JAK-STAT signalling has been identified as having a potential role in sustaining vascular inflammation. In particular, STAT-1 signalling appears to regulate the activity of vasDCs as well as controlling T cell ...
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Differences in systemic adaptive immunity contribute to the ‘frequent exacerbator’ COPD phenotype
... cells and inferred that this might render COPD patients more susceptible to infections [8]. However, our findings suggest that the effect of exhausted T-cells and regulatory T-cells on exacerbation susceptibility may be ...
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