human leukocyte antigen-DR
Serial increase of IL 12 response and human leukocyte antigen DR expression in severe sepsis survivors
... Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome: results from a randomized, double-blind, placebo-controlled ...
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The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients
... neutrophil function. Data from uncontrolled clinical studies supported the “Cytokinetic Theory” [13, 28]. However, the mechanism of PMX-HP in improving mHLA-DR expression is still unclear. We hypothesized that ...
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Comparison of monocyte human leukocyte antigen DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study
... Another potential explanation for the superiority of HLA-DR expression over LPS-induced TNF-ɑ production as a predictor of poor outcomes in the present study is the differing degree to which these assays have been ...
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Cytokine regulation of human leukocyte antigen DR[alpha] (HLA DR[alpha]) gene expression in human tumour cell lines
... Reporter gene assays with HLA-DRa 680 promoter fragment CAT reporter gene assays employing the glioblastoma cell line U138MG transiently transfected with the vector pDRa680CAT demonstrat[r] ...
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Lack of recovery in monocyte human leukocyte antigen DR expression is independently associated with the development of sepsis after major trauma
... The present study has a number of limitations. First, it is a single-center study. The findings clearly need to be confirmed by a multicenter study. Second, the study enrolled only 105 patients. Though relatively small, ...
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Changes of monocyte human leukocyte antigen DR expression as a reliable predictor of mortality in severe sepsis
... Expression of cell surface HLA-DR on monocytes was measured by flow cytometry (EPICSXL; Beckman Coul- ter, Inc., Fullerton, CA, USA). Staining and cell acquisi- tion for flow cytometry were performed within 1 hour ...
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Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress
... HLA-DR: Human leukocyte antigen-DR isotype; EV: Extracellular vesicle; DCs: Dendritic cells; GvHD: Graft versus host disease; MI: Myocardial infarction; MS: Multiple sclerosis; ALS: ...
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Original Article Expression of monocyte HLA-DR and blood lactic acid level in patients with sepsis and correlation with prognosis
... in human body should be less than 2 mmol/L, and if it is higher than that, it cannot be completely elimi- nated by the liver ...HLA-DR, human leukocyte antigen-DR; BLA, blood ...
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Clinical review: flow cytometry perspectives in the ICU from diagnosis of infection to monitoring of injury induced immune dysfunctions
... studying human clinical samples, particularly in infl ammatory Figure ...monocyte human leukocyte antigen-DR expression (mHLA-DR) measurements, the gated region includes all ...
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The relationship between human leukocyte antigen DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population
... It is globally recognized that HLA class II molecules, categorized into three sub-regions: HLA-DR, −DQ and -DP , are key determinants in the immune response to HCV infection through the effective presentation of ...
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Persistent Antigens Hypothesis: The Human Leukocyte Antigen (HLA) Connection
... the human genome, thereby maximizing species resistance to foreign antigens and promoting ...and DR), a large number of antigens can be effectively ...
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Neuropathology of SUDEPRole of inflammation, blood-brain barrier impairment, and hypoxia
... and human leukocyte antigen–antigen D related (HLA-DR) would be more globally upregulated in control regions and in key autonomic-regulatory ...
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Significant Associations of the rs3104413 Single-nucleotide Polymorphism in the HLA Region with Type 1 Diabetes
... Type 1 diabetes (T1D) is a multifactorial disease in which immune system cells destroy pancreatic β-cells responsible for producing insulin in body [1]. T1D is a disease of major public health concern [2]. It is ...
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The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
... of antigen presenting cells, such as den- dritic cells and ...of human peripheral blood monocytes to immature DCs resulted in upregulation of antigen presentation markers HLA- DR (human ...
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Functional disruption of human leukocyte antigen II in human embryonic stem cell
... With conserved binding regions, HLA II genes are regulated by a same regulatory complex consists of three RFX factors (RFXAP, RFX5, RFXANK) and CIITA [14, 15]. This complex regulates not only the genes encod- ing ...
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Low expression of human histocompatibility leukocyte antigen DR is associated with hypermethylation of human histocompatibility leukocyte antigen DR alpha gene regions in B cells from patients with systemic lupus erythematosus
... the DR alpha ...hypermethylated DR genes might express no or few DR antigens; (b) the ratio of cells with differently methylated DR genes is consistent in normal individuals, while, in SLE ...
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Association of human leukocyte antigen-DRB haplotype in multiple sclerosis population of Khuzestan, Iran
... two DR β-chain molecules including HLA-DRB5*01:01 and ...with DR alpha result in functional surface molecules including DR2β (-DRA*0101, -DRB1*1501) and DR2α (-DRA*0101, ...
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Activities of stromal and immune cells in HPV-related cancers
... HLA: Human leukocyte antigen; HLA-DR: Human leukocyte antigen D related; HNSCC: Head and neck squamous cell carcinoma; HPV: Human Papillomavirus; hrHPV: High risk ...
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Comparison of efficacy and safety of epalrestat with methylcobalamin in patients with diabetic neuropathy
... HbA1C Glycosylated Hemoglobin HDL High Density Lipoprotein HHS HLA-DR Hyperosmolar hyperglycaemicnonketotic coma Human Leukocyte Antigen – antigen D Related HNF Hepatocyte nuclear transc[r] ...
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THE PROFILE OF HUMAN LEUKOCYTE ANTIGEN CLASS I IN PATIENTS WITH SCHIZOPHRENIA
... Schizophrenia (SZ) is a mental disorder characterized by abnormal social behavior and failure to understand reality. [1] It is a disabling disorder characterized by positive (delusions and hallucinations), negative ...
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