human lung fibroblasts
Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells
... that fibroblasts are capable of inter- acting with T-lymphocytes, we set out to determine whether the interaction between normal human lung fibroblasts and T-cells could lead to a functionally ...
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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
... in human lung ...in lung dis- eases, and several lines of evidence suggest that CTGF is also a profibrotic mediator of pulmonary fibrotic dis- eases such as IPF [7, ...bleomycin-stimulated ...
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Rapamycin Inhibits Transforming Growth Factor β1 Induced Fibrogenesis in Primary Human Lung Fibroblasts
... in human pulmonary fibroblasts was through the mTOR-p70S6K pathway, phosphorylation levels of mTOR-Ser2448 and p70S6K-Thr389 in human lung fibroblasts were determined by Western ...in ...
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Anti-inflammatory effects of budesonide in human lung fibroblasts are independent of histone deacetylase 2
... from human lung fibroblasts. Methods: Human lung fibroblasts (HFL-1 cells) were stimulated with interleukin (IL)-1b plus tumor necrosis factor (TNF)-α in the presence or absence ...
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Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts
... inflammatory lung diseases [32,33]. Fibroblasts are the main cell type of lung paren- chyma: these cells secrete ECM molecules as well as pro- teinases, and physiologically regulate matrix ...HFL-1 ...
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Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
... with human lung tryptase added to human lung fibroblasts ...on fibroblasts does not appear to be mediated via the thrombin receptor since it has been shown that tryptase does not ...
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Relaxin induces an extracellular matrix degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
... the human cytokine, relaxin, to block extracellular matrix deposition by human lung fibroblasts in vitro, and to inhibit lung fibrosis in a bleomycin-induced murine ...by human ...
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Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: Synchronous and differential responses
... normal human lung fibroblasts at four hours after expo- sure to ...in fibroblasts, the bystander response centers on stress signaling and cytokines, rather than on classic radiation responses ...
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Interleukin (IL) 4 and IL 13 act on human lung fibroblasts Implication in asthma
... of human lung fibroblasts derived from either fetal (ICIG7) or adult (CCL202) tissue as well as from a Th2-type stromal reaction (FPA) to IL-4 and IL-13, we provide evidence that human ...
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The effects of collagen-rich extracellular matrix on the intracellular delivery of glycol chitosan nanoparticles in human lung fibroblasts
... IPF fibroblasts, both with and without collagen ...IPF fibroblasts cultured on collagen (Figure 2A and C). In contrast, lung fibroblasts in the absence of collagen showed no cytoplasmic NIRF ...
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Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis
... normal human lung fibroblasts by vanadium pentoxide (V 2 O 5 ) that appear to have important functions in inflammation, fibrosis and ...the lung fibrotic reaction to V 2 O 5 ...
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Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and <em>Drosophila melanogaster</em>
... MRC5 human lung fibroblasts in vitro and in an in vivo model using the fruit fly Drosophila ...MRC5 lung cells, indicating cellular damage and ...in human lung fibroblasts ...
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Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts
... Methods: The effects of roflumilast and indacaterol treatment were characterized on transforming growth factor b1 (TGFb1)-treated normal human lung fibroblasts (NHLF). NHLF were evaluated for ...
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BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas
... in lung fibroblastic ...primary human fibroblasts (CCL- 171) with BMP2 in a physiological concentration of 200ng/ml for 24 ...using human exonic evidence-based oligonucleotide (HEEBO) ...
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Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study
... IPF fibroblasts for 48 ...to fibroblasts monolayers grown to confluence in 6-well tissue culture plates (direct contact) or fibroblasts (low compartment) and MUTZ-3 DCs (high compartment) were ...
6
RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis
... Transient transfection of dominant-negative RhoA (RhoA T19N) and constitutively active (RhoA G14V) constructs were utilised to confirm the regulatory role of Rho in cyc- lin D1 induction (Fig 3a). These data revealed ...
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Endogenous lysophosphatidic acid (LPA1) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts
... calcium mobilization in HLF after treatment with a range of concentrations of eleven LPA analogues (see Supplementary table 1 for chemical structures). These eleven analogues can be divided into four sub groups of short ...
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Suberanilohydroxamic acid prevents TGF β1 induced COX 2 repression in human lung fibroblasts post transcriptionally by TIA 1 downregulation
... in lung fi broblasts post-transcriptionally through a novel TIA-1-dependent mechanism and provide new insights into the mechanisms underlying its potential anti fi brotic ...
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Effects of interferon gamma on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts
... distribution of log fluorescence intensity in both control and IFN-gamma exposed cells was normally distributed about the mean, indicating that discrete subpopulations with respect to receptor expression were not ...
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Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
... pulmonary human fibroblasts, may be induced by tumor necrosis factor-α, which is pro- duced by mast cells [50, ...in fibroblasts from IPF lungs compared to control lungs ...
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