Human malaria
Transgenic Rodent Plasmodium berghei Parasites as Tools for Assessment of Functional Immunogenicity and Optimization of Human Malaria Vaccines
... adapted human malaria para- sites, enabling the assessment of functional immune responses against malaria antigens in vivo; however, these animal models are not widely accessible, and the cost of ...
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Functional Conservation of P48/45 Proteins in the Transmission Stages of Plasmodium vivax (Human Malaria Parasite) and P berghei (Murine Malaria Parasite)
... Studies employing targeted gene disruption in P. falciparum and P. berghei have demonstrated a critical role for P48/45 in male gamete fertility (22), and the presence of P48/45 proteins is imperative for transmission of ...
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Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria naïve volunteers: effect of injection volume and dose on infectivity rates
... Controlled human malaria infection (CHMI) has facilitated progress in research and development of vaccines and drugs providing the possibility to infect volunteers under controlled conditions [5, ...
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Mitosis in the Human Malaria Parasite Plasmodium falciparum
... Once released into the bloodstream, merozoites invade red blood cells and continue to expand their numbers with blood- stage schizogony (10). All of the clinical symptoms of malaria (fever, anemia, and ...
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Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections
... Figure 2. Deworming increases P. vivax density. Effect of albendazole treatment on Plasmodium density shown by the fold-change in density (± 1se) compared to untreated individuals. Due to the inverse, doubling nature of ...
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Tumor necrosis factor reduces Plasmodium falciparum growth and activates calcium signaling in human malaria parasites
... As TNF reduces parasitemia we have searched for a target that might be involved in the control of cell cycle proliferation. A possible target in- volved in the TNF response could be P. falciparum Proliferating-Cell Nu- ...
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Use of gene expression studies to investigate the human immunological response to malaria infection
... with malaria ‘naturally’ in the field (n = 13, 57%), however some related to controlled human malaria infection (CHMI) studies (n = 6, 26%), or cells stimulated with Plasmodium in vitro (n = 6, ...to ...
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A dual colour fluorescence in situ hybridization (FISH) assay for identifying the zoonotic malaria parasite Plasmodium knowlesi with a potential application for the specific diagnosis of knowlesi malaria in peripheral level laboratories of Southeast Asia
... of human malaria parasites, ...Zoonotic malaria is currently a relatively neglected aspect of human ...of human settlements in the vicinity of forests, and deforestation, are increasing ...
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Human infection with Plasmodium knowlesi on the Laos-Vietnam border
... with human malaria parasites often occurred in people older than 15 (Tables 2 and 3), and a simi- lar tendency was reported in Southern Vietnam ...suffer malaria disease and oc- casionally develop ...
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S1P Is Associated with Protection in Human and Experimental Cerebral Malaria
... Based on the above observations sug- gesting a role for S1P in the regulation of biological processes implicated in the pathogenesis of CM, we hypothesized that S1P signaling is affected during ma- laria infection in a ...
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NOVEL ANTIMALARIAL AGENTS AND TARGETS: AN OPTIMISM OVER RESISTANCE
... WHO malaria report 2013, it is currently recommended to develop highly cost-effective strategies for the use of antimalarial medicines for the prevention of morbidity, targeting groups at high risk of Plasmodium ...
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Strong concordance between percent inhibition in oocyst and sporozoite intensities in a Plasmodium falciparum standard membrane feeding assay
... of malaria has been reduced significantly in the last 15–20 ...mated malaria related deaths in 2016, mostly due to Plasmodium falciparum ...of malaria eradi- ...in human hosts against sexual ...
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Human biting activity, spatial–temporal distribution and malaria vector role of Anopheles calderoni in the southwest of Colombia
... The correlation between An. calderoni abundance and rainfall and relative humidity could suggest that breed- ing sites of this species are temporary and that increases in precipitation could generate favourable breeding ...
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Mosquito electrocuting traps for directly measuring biting rates and host preferences of Anopheles arabiensis and Anopheles funestus outdoors
... a human volunteer conducting HLC, (2) a small MET with one adult male human (MET-SH), (3) a large MET containing one adult male human (MET- LH), and (4) a large MET baited with two female calves (~ 2 ...
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Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins
... or human proteins with likely nuclear function, mitochondrial localization, roles in basic cellular processes (including translation, RNA processing, protein degradation, ubiqui- tin metabolism and ...
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Rapid survey of malaria prevalence and malaria risk factors in pregnant women
... of malaria if left untreated is 82.6% of people said malaria can kill and 96% of people know malaria can interfere with work(Ngambut & Sila, ...from malaria risk factors that knowledge of ...
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Going beyond personal protection against mosquito bites to eliminate malaria transmission: Population suppression of malaria vectors that exploit both human and animal blood
... However, there are also immediate, substantive oppor- tunities to develop and evaluate delivery systems in low income and middle income countries (LMICs) for well- established mosquito abatement technologies that are ...
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Re imagining malaria: heterogeneity of human and mosquito behaviour in relation to residual malaria transmission in Cambodia
... the malaria season), especially at those residences in the more forested areas where farmers are tired after an exhausting day’s work and the lack of electricity limits social ...though malaria vectors ...
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Molecular basis of human cerebral malaria development
... of malaria infection Gene regulation is a process responsible for controlling the rate and manner of gene ...system. Human gene expression is mainly regulated at the transcriptional and translational ...
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Adjunctive therapy for severe malaria: a review and critical appraisal
... of malaria (SM and/or CM, coma), or study characteristics (limited num- ber of patients per study, different and no comparable age of the populations, different treatment doses, studies not designed to identify ...
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