human malignancies
Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis
... In this meta-analysis, we investigated the prognos- tic values of Lin28A and Lin28B for multiple human malignancies. Combining the outcomes of studies regarding the association of lin28 expression and tumor ...
8
Understanding the role of NRF2-regulated miRNAs in human malignancies
... Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a key transcription factor that regulates the expression of over a hundred cytoprotective and antioxidant genes that provide cellular protection from reactive oxygen ...
13
Prognostic significance of AMPK in human malignancies: A meta-analysis
... Methods: Literatures were retrieved via searching databases of PubMed, Web of Science, Embase and Cochrane Library. Studies comparing the prognostic significance between different AMPK levels among human ...
10
<p>Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies</p>
... Abstract: Human malignancies are often the result of overexpressed and constitutively active receptor and non-receptor tyrosine kinases, which ultimately lead to the mediation of key tumor- driven ...
11
Single cell sequencing reveals karyotype heterogeneity in murine and human malignancies
... Single cells for the purpose of single-cell sequencing were isolated from thymuses by dissecting the organ and mincing the tissue through a 100 μm cell strainer. Cells were washed in PBS twice before stored in FBS with ...
15
The role of PML ubiquitination in human malignancies
... in human cancers from multiple origins, such as prostate adenocarcinoma, colon adenocarcinoma, breast carcin- oma, lung carcinoma, lymphoma, CNS tumors, and germ cell ...
7
<p>Prognostic significance of the ratio of fibrinogen and albumin in human malignancies: a meta-analysis</p>
... ratio of fi brinogen and albumin was exhibited in several types of human cancers. 10–13 For example, the patients with high FAR or low AFR had signi fi cantly worse survival than those with low FAR or high AFR in ...
13
NON-AQUEOUS PARENTERAL PREPARATION OF AN ANTICANCER AGENT – A REVIEW
... treating human malignancies mainly breast cancer, non-small cell lung cancer, prostate cancer, gastric cancer, head and neck cancer by inhibiting microtubules, a cell protein helpful in cell division this ...
5
The claudin family of proteins in human malignancy: a clinical perspective
... Abstract: Tight junctions, or zonula occludens, are the most apical component of the junc- tional complex and provide one form of cell–cell adhesion in epithelial and endothelial cells. Nearly 90% of malignant tumors are ...
9
<p>Hypoxia-Induced Cleavage Of Soluble ephrinA1 From Cancer Cells Is Mediated By MMP-2 And Associates With Angiogenesis In Oral Squamous Cell Carcinoma</p>
... MMPs are pivotal factors in cancer invasion and angiogen- esis through matrix remodeling. 25 They are highly expressed in multiple human malignancies. Among them, MMP-2 and MMP-9 are the most ef fi cient ...
9
The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Ruchi Singhal 1and Eugene S. Kandel 1*
... While new drugs aimed at BRAF-mutated cancers are entering clinical practice, cells and tumors with activating Ras mutations are relatively resistant to those and quite a few other anti-cancer agents. This inspires the ...
9
Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion
... Due to the evidence that the signalling pathways altered in mesothelioma and affected by artichoke leaf extracts are common to other human malignancies we might expect that cynara scolym[r] ...
17
The role of the ubiquitination proteasome pathway in breast cancer: Applying drugs that affect the ubiquitin proteasome pathway to the therapy of breast cancer
... This pathway has been validated as a target for antineoplastic therapy using both in vitro and preclinical models of human malignancies, and is influenced as part of the mechanism of action of certain ...
7
Evaluation of the new TNM staging system for thymic malignancies: impact on indication and survival
... The proposed IASLC/ITMIG staging system was first published 2014 and is a new evidence-based TNM-staging system for thymic malignancies according to the TNM classification of the UICC of malignant tumors (Table 1) ...
8
Laparoscopic total pelvic exenteration for pelvic malignancies: the technique and short time outcome of 11 cases
... Eight males and three females were diagnosed as pelvic malignancies by biopsy and were selected to receive LTPE from April 2011 to September 2015. The selected criteria included the following: preoperative ...
9
A Search for a Tumor Suppressor Gene Responsible for B-Cell Chronic Lymphocytic Leukemia: Old Leads and New Hopes
... Gene inactivating mutations in KCNRG in CLL have not yet been identified. Nevertheless, some other findings indicate that KCNRG inactivation might play a role in tumorigenesis. Differences in the level of expression for ...
8
Concurrent treatment of metastatic breast and metastatic renal cell carcinoma: A case report
... common malignancies, with an increasing number of well-tolerated targeted ...(multiple malignancies), did not reveal increased risk of developing renal cancer after breast cancer, or of breast cancer after ...
6
The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies
... The HIV protease inhibitor ritonavir is potentially an antican- cer agent. Its mechanisms of action include inhibition of the proteasome, inhibition of HSP90, inhibition of CYP3A4 and P-glycoprotein, and modulation of ...
8
Antiretrovirals: Need for an effective drug delivery
... A more advanced version of controlled delivery is the targeted delivery. Targeted delivery exhibits all the advantages of the controlled delivery and at the same time facilitates delivery of the drug to the target site. ...
6
The prevalence of opportunistic infections and malignancies in autopsied patients with human immunodeficiency virus infection in Japan
... Although mortality rates have decreased dramatically with the use of ART, its effect in many patients with AIDS is limited, and AIDS-associated complications remain a leading cause of death [14,15]. Additionally, ...
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