Human tissue factor pathway inhibitor-2
Reduced expression of tissue factor pathway inhibitor-2 contributes to apoptosis and angiogenesis in cervical cancer
... Human TFPI-2, also known as placental protein (PP5) and matrix-associated serine protease inhibitor (MSPI), is an ECM-associated Kunitz-type serine proteinase inhi- bitor [15]. TFPI-2 plays an ...
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Tissue factor pathway inhibitor 2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis
... cDNA. Human recombinant IL-1β and TNF- α were obtained from Endogen ...USA). Human recombinant CD40L was generated as described previously ...Corp. Human recom- binant cathepsin S and cathepsin K ...
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The effects of tissue factor pathway inhibitor and anti beta 2 glycoprotein I IgG on thrombin generation
... recombinant human TFPI (rTFPI) were purchased from American Diagnostica ...Purified human prothrombin, purified human β2GPI, affinity purified polyclonal rabbit anti-human β2GPI antibodies and ...
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The effects of tissue factor pathway inhibitor and anti-b-2-glycoprotein-I IgG on thrombin generation
... recombinant human TFPI (rTFPI) were purchased from American Diagnostica ...Purified human prothrombin, purified human β2GPI, affinity purified polyclonal rabbit anti-human β2GPI antibodies and ...
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Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2
... of tissue samples was approved by the Local Scientific Ethical Committee (San Gerardo Hospital, Monza, Italy) in compliance with the Declaration of ...Briefly, tissue specimens were digested by type I ...
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Anti tissue factor pathway inhibitor activity in patients with primary antiphospholipid syndrome
... mg/ml human prothrombin (Enzyme Research Laboratories, Swansea, UK) in phos- phate-buffered saline (PBS) (0´01 mol/l phosphate, 0´145 mol/l NaCl, pH ...anti- human IgG or IgM was added for 1 ...
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The effects of antioxidant vitamins on the expression of tissue factor and tissue factor pathway inhibitor genes in human monocytic and endothelial cell lines
... RT-PCR is an in vitro technique. It involves the conversion of mRNA to complementary cDNA. This cDNA then serves as a template for the amplification of a specific DNA fragment that lies between two regions of specific ...
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A novel anticoagulant activity assay of tissue factor pathway inhibitor I (TFPI)
... France) as described in detail elsewhere [11]. In both assays a monoclonal antibody was used to catch TFPI. Two other monoclonal antibodies conjugated with peroxidase were used to detect either free, i.e. full-length ...
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Upregulated matrix metalloproteinase-2 and downregulated tissue factor pathway inhibitor-2 are risk factors for lymph node metastasis and perineural invasion in pancreatic carcinoma
... risk factor for developing LNM; the combina- tion of intratumoral hypoxia-inducible factor-1 α , vascular endothelial growth factor, and MMP-2 staining may also be useful as a molecular ...
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Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit
... Measurement of TFPI activity. TFPI activity was measured in cit- rated plasma samples via the Actichrome TFPI assay as described by the manufacturer (American Diagnostica, Green- wich, Connecticut, USA). Diluted plasma ...
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Effect of a 3-Week Low-Calorie Diet and Balneological Treatment on Selected Coagulation Parameters in Morbidly Obese Patients
... independent factor contributing to the risk of developing thrombosis [6, 8, ...9]. Tissue factor is the main activator of the extrinsic coagulation pro- cess, which plays a crucial role in thrombin ...
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Recombinant factor VIII in the management of hemophilia A: current use and future promise
... recombinant factor VIII there are many studies in patients with hemo- philia A, but none that directly compares one generation with another product or ...in inhibitor formation in children who have never ...
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Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor
... The effect of using three different sourcesof tissue factor recombinant,human brain and rabbit brain thromboplastinsin the TFPI assay was examined.. Of most significance was the apparent[r] ...
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Heparanase: a multitasking protein involved in Extarcellular Matrix (ECM) remodeling and cellular signaling
... growth factor (VEGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF) and FGF family ...proangiogenic factor regulating tumor angiogenesis ...nervous tissue and at ...
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Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock
... that tissue factor pathway inhibitor (TFPI) plays a significant role in vivo in regulating coagulation that results from exposure of blood to tissue factor after vascular injury ...
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Prothrombotic profile in patients with vasospastic or non vasospastic angina and non significant coronary stenosis
... Ambulatory venous blood sampling for vWF, total TFPI (t-TFPI) antigen, free TFPI (f-TFPI) antigen, PAI-1anti- gen and fibrinogen was performed between 08:30 and 09:30 a.m. in a fasting condition, without vascular com- ...
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Imbalance of tissue inhibitors of metalloproteinases (TIMP) – 1 and – 4 serum levels, in patients with inflammatory bowel disease
... Increased levels of TIMP-1 have also been associated with the presence of fibrotic strictures in CD [11]. It is well known that, TIMPs are important markers of fibrosis. In addition, CD and especially its stenotic form ...
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Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits
... recombinant human TFPI significantly reduced development of GFD (fibrin scores, TFPI treated ...• tissue factor • pro- coagulant activity • ...
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The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo
... Tissue factor pathway inhibitor (TFPI) is a plasma Kunitz-type serine protease inhibitor that directly inhibits coagulation Factor Xa and also inhibits tissue ...
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Promoter hypermethylation and silencing of tissue factor pathway inhibitor 2 in oral squamous cell carcinoma
... Kruppel-like factor 6 (KLF6) binding site, suggesting that the aberrant DNA methylation in the KLF6 binding site diminishes the binding of transcription factor KLF6 to the TFPI-2 promoter to decrease ...
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