humanized mice
Comparative pathogenesis of Ebola virus and Reston virus infection in humanized mice
... (NSG-A2) mice reconstituted with human hematopoiesis to compare Ebola virus and Reston virus pathogenesis in a human- like ...infected mice, a finding that was linked to exacerbated inflammation and viral ...
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Mosquito Bite Delivery of Dengue Virus Enhances Immunogenicity and Pathogenesis in Humanized Mice
... by humanized mice after infection, we used a commercially available kit for quantification of total human IgM and IgG antibodies and a modification of the same assay to measure DENV-specific anti- bodies, ...
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HCV infection-associated hepatocellular carcinoma in humanized mice
... survival and cell proliferation genes [12]. Activation of β-Catenin in HCC as contrasted with the surrounding (normal) liver tissue was recently reported from HCV- infected patients [31]. Considering the significance of ...
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Therapeutic Efficacy of Vectored PGT121 Gene Delivery in HIV-1-Infected Humanized Mice
... FIG 4 Vectored PGT121 reduces viral loads in HIV-1-infected humanized mice. (A and B) Serum PGT121 concentrations (A) and log plasma HIV-1 viral RNA (copies/ml) (B) in BLT mice following vectored ...
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Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results
... Targeting BCSCs is an important strategy to treat BC. DC therapy is a promising alternative approach to targeting BCSCs. This study showed that DC-primed BCSC-derived antigens efficiently inhibited the tumor progression ...
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Individualized Responses of Gut Microbiota to Dietary Intervention Modeled in Humanized Mice
... ex-GF mice following a defined dietary interven- ...of humanized mice, in order to better delineate individualized responses and changes in specific metabolites, larger patient cohorts will need to be ...
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Microbiota control immune regulation in humanized mice
... our findings with individual antibiotics and cultures with supernatants and insoluble material from the pellets suspended in PBS suggest that soluble products account for the effects on IL-27 production. Further studies ...
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Human Cytomegalovirus Infection Suppresses CD34+ Progenitor Cell Engraftment in Humanized Mice
... environment such that the virus promotes the differentiation of myeloid cells but inhibits lymphoid blood cell production in the periphery of humanized mice. This work complements and expands on our ...
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Tandem bispecific neutralizing antibody eliminates HIV 1 infection in humanized mice
... al cities in the world (45) but also in small local communities and subpopulations, such as men who have sex with men (48, 49). On the other hand, most bnAbs are not effective against all circulating global HIV-1 strains ...
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Monitoring HIV DNA and cellular activation markers in HIV infected humanized mice under cART
... in mice vs PBMCs in human) or explained by the large inter-individual het- erogeneity of HIV DNA seen in mice and patients [35], and the rather limited number of n = 33 mice used to look into this ...
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Humanized mice as a model for rheumatoid arthritis
... content of synovial joint cartilage over three generations. Since the CoII-HCgp-39 transgene functioned as a neo- self-antigen, the DR*0401 transgenic mice were tolerant to HCgp-39. However, they did break ...
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Modeling HCV infection, immunopathogenesis, and therapy in humanized mice
... infected mice with enhanced effector ...HSC/Hep mice to generate human immune responses to HCV demonstrates the vast potential of this model for HCV immunology research, and additional future directions in ...
137
82124.2-20150820152220-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
... of humanized mice and that persistent HIV-1 infection in this model depletes ILC3s, as observed in chronic HIV-1–infected ...HIV-1–infected mice, effective antiretroviral therapy reversed the loss of ...
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Utility of Humanized BLT Mice for Analysis of Dengue Virus Infection and Antiviral Drug Testing
... of humanized mice infected with dengue virus reported that the clinical outcome for infected mice depended greatly on the virus strain used as the inoculum (32, 43, ...that humanized BLT ...
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1-s2.0-S0149291819304047-main.pdf
... immunodeficient mice are useful systems for studying viruses such as ZIKV, in other instances it is necessary to introduce specific human genes or engraft human cells or organ systems into the mouse to generate ...
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Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse model
... BLTS humanized mice beginning at 8 weeks after infection and showed that ART significantly reduces ...BLTS humanized mice resulted in viral load rebound within 2 weeks, with viral load levels ...
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Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2−/−γc−/− Mice
... ⴚ/ⴚ mice humanized with cord blood-derived human hematopoietic stem cells produce hu- man T cells that express the major HHV-6A receptor, ...control mice had undetectable viral ...in humanized ...
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journal.pmed.0050016.PDF
... Using humanized mice to address this need is attractive because they allow in vivo studies of HIV-1 infection of human ...producing humanized mice is trans- planting human hematopoietic stem ...
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In vivo analysis of the effect of panobinostat on cell associated HIV RNA and DNA levels and latent HIV infection
... T cells. Strategies to reverse latency and clear persistent infection may bring us closer to a cure by (1) inducing HIV expression in latently infected cells through latency- reversing agents, followed by (2) clearance ...
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jix547.pdf
... Human immunodeficiency virus type 1 (HIV-1) reservoirs, which harbor replication competent proviruses and persist during combination antiretroviral therapy (cART), compose one of the major barriers to curing HIV-1 ...
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