hydrogen isotope exchange processes
Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles
... We then expanded this study to investigate the directing group ability of benzannulated substrates, 13–15 (Table 2, rows 1-2). In competition experiments between each benzannulated substrate (13 vs. 14, 13 vs. 15, and 14 ...
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Anion effects to deliver enhanced iridium catalysts for hydrogen isotope exchange processes
... scope has been demonstrated through improved global deuterium labelling of the drug molecule Niclosamide in 2-MeTHF. Our on-going efforts in this area are focused on the further application of optimal catalyst, 1d, in ...
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Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes
... provides a much clearer indication of the solvents that will support deuteration of the substrate. The substitution of DCM or ethereal solvent molecules by acetophenone occurs in an exothermic reaction (i.e. the ...
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Iridium(I)-catalyzed regioselective C[BOND]H activation and hydrogen-isotope exchange of non-aromatic unsaturated functionality
... [4] For examples of Ir complexes showing stoichiometric olefinic C-H insertion, see: a) P. O. Stoutland, R. G. Bergman, J. Am. Chem. Soc. 1988, 110, 5732-5744; b) D. Hermann, M. Gandelman, H. Rozenberg, L. J. W. Shimon, ...
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Iridium(I)-catalyzed Regioselective C-H Activation and Hydrogen Isotope Exchange of Non-aromatic Unsaturated Functionality
... [4] For examples of Ir complexes showing stoichiometric olefinic C-H insertion, see: a) P. O. Stoutland, R. G. Bergman, J. Am. Chem. Soc. 1988, 110, 5732-5744; b) D. Hermann, M. Gandelman, H. Rozenberg, L. J. W. Shimon, ...
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Iridium-catalyzed Csp3-H activation for mild and selective hydrogen isotope exchange
... HIE processes, see: (a) Cochrane, ...ortho‐Directed Hydrogen Isotope ...V. Hydrogen‐Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with ...
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The synthesis of highly active iridium(I) complexes and their application in catalytic hydrogen isotope exchange
... H/D exchange step (13 → 17) is calculated to be rapid, with an activation barrier of ...H/D exchange processes appears to involve the oxidative addition or reductive elimination of the ortho-C-H ...
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The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions
... such exchange processes far in excess of the industry standard, Crabtree’s catalyst, with excellent levels of labelling being achieved over short reaction times (< 90 min) and at very low metal complex ...
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Site-selective deuteration of N-heterocycles via iridium-catalyzed hydrogen isotope exchange
... To understand the origins of this notable selectivity, the reaction was studied computationally, in order to establish the relative energies of binding and C − H activation for each of the possible labeling sites. In ...
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Hydrogen water isotope exchange in a trickle bed column by process simulation and 3D computational fluid dynamics modelling
... multicomponent hydrogen isotopic compositions at each scrubbing ...given hydrogen stream in the column. The optimum exchange temperature decreases with increased hydrogen flow ...isotopic ...
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C–H functionalization for hydrogen isotope exchange
... Generally, heterogeneous catalysis is applied if several deuterium/tritium atoms are required to be introduced. Therefore, this method is mainly applied to prepare deuterated MS standards for LC-MS/MS analysis. Another ...
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ABSTRACTS: October 1962153-160
... Ni/A1,0, has a similar catalytic activity to Pt black and Pd black in this exchange reaction, but with Ni lSi0 and Nilkieselguhr there is no exchange of hydrogen in the be[r] ...
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Algorithm design of the ratio control of chlorine and hydrogen in hydrogen chloride synthesis
... and hydrogen make direct synthesis of hydrogen chloride usually, then hydrochloric acid was product though water absorbing the hydrogen ...The hydrogen and chlorine are inputted into the ...
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Stable oxygen and hydrogen isotope fractionation factors for the Goethite (hematite)-water system
... This work investigates into the isotopic signature of both oxygen and hydrogen in synthetic goethite and hematite. It includes an attempt to determine fractionation factor at a specific temperature, and isotopic ...
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Thallium elemental behavior and stable isotope fractionation during magmatic processes
... magmatic processes and examine the inaccessible mantle source, the assumption being that the partitioning of the two ratioed elements is identical in the given phase ...
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The influence of oxygen isotope exchange between CO2 and H2O in natural CO2-rich spring waters : implications for geothermometry
... oxygen isotope exchange with CO 2 , high temperature equilibration with bedrock minerals and mineral dissolution and precipitation reactions on the CO 2 -rich water isotopic ...oxygen isotope ranges ...
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Protein Hydrogen Exchange, Dynamics, and Function
... anion exchange is not as ...anion exchange given that their primary sequence is ...ion exchange column can be estimated by its pI, which can be calculated from its ...
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Bipolar carbon and hydrogen isotope constraints on the Holocene methane budget
... records confirm an isotopic shift towards lighter values in the meteoric water in the summer monsoon regions of the North- ern Hemisphere from 11 to 8 ka BP (Wang et al., 2014) and an inverse relationship in the Southern ...
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Fulcher-α Band Spectra in Mixed Hydrogen Isotope Plasmas
... mixed hydrogen isotopes ...impact processes, surface recombina- tions, and relaxations by inter-molecular collisions deter- mine the ro-vibrational ...
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Kinetics of Hydrogen Isotope Absorption for Well Annealed Palladium Platinum Alloys
... dilute hydrogen concentration region in a temperature region from 274 to 357 K by means of constant volume method, where samples were annealed well at 973 K under vacuum before measurements to remove defects ...
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