Hydrophobic pocket
The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.
... a hydrophobic pocket where proline-containing peptide substrates and the immunosuppressive drug cyclosporine A ...the hydrophobic pocket of ...
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Nsp7 and Spike Glycoprotein of SARS-CoV-2 are envisaged as Potential Targets of Vitamin D and Ivermectin
... a hydrophobic cleft formed between two helices arranged in an elbow like pattern (PDB code: 1J78, Verboven et al, ...similar hydrophobic pocket in the cofactor nsp7 which is reminiscent of the ...
13
Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2
... The study of MD-2, as a target for anti-inflammatory therapy, has drawn great attention and a variety of MD-2 inhibitors have been reported, among which lipid IVa is a popular lipid-like antagonist. Lipid IVa, an ...
9
1 Amino 6 chloro 2 (1H pyrrol 2 yl)benzimidazole (RS 1350)
... HIV-1 Reverse transcriptase (RT), the enzyme which catalyses the transcription of viral single-stranded RNA into double- stranded DNA, is the most investigated target in searching for anti-AIDS drugs. In the last decade, ...
8
A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus
... In all complexes, P-F241 is deeply buried in a hydrophobic pocket of the N-NTD located between helices ␣I2 (residues S131, R132, and Y135) and ␣ N1 (residues M50 and I53) and the H151 loop (Fig. 2). These ...
15
Alternative conformations of the x region of human protein disulphide isomerase modulate exposure of the substrate binding b’ domain
... a hydrophobic pocket on one face of the domain which is capped by the x region (Fig ...a hydrophobic pocket comprising the sidechains of F287, F288, I301, M307 and the alkyl chain of ...make ...
32
Identification of a Small-Molecule Entry Inhibitor for Filoviruses
... through hydrophobic interactions, including an interchain di- sulfide bond (37, ...S2 hydrophobic pocket of EBOV-GP are important and that compound 7 selectively binds in this pocket to ...
14
The UmuC subunit of the E coli DNA polymerase V shows a unique interaction with the β clamp processivity factor
... The UmuC binding motif is internal to the protein One point of interest is that, unusually, although not uniquely, the UmuC clamp-binding motif is internal, lying between the LF domain and the CTD (the latter currently ...
13
Molecular mechanism of ligand recognition by membrane transport protein, Mhp1
... a hydrophobic pocket accommodating an extended conformation of a 5-substituent have been substantiated by a combination of mutagenesis, molecular dynamics simulations and comparison of binding efficiencies ...
15
Molecular mechanism of ligand recognition by membrane transport protein, Mhp1
... a hydrophobic pocket accommodating an extended conformation of a 5-substituent have been substantiated by a combination of mutagenesis, molecular dynamics simulations and comparison of binding efficiencies ...
15
Mutations in the Parainfluenza Virus 5 Fusion Protein Reveal Domains Important for Fusion Triggering and Metastability
... A recent study using a model of the measles virus F protein based on the PIV5 F atomic structure suggested that single point mutations in the Ig-like domain of the measles virus F model completely ablated fusion ...
12
Macrophage Migration Inhibitory Factor (MIF) Enzymatic Activity and Lung Cancer
... the hydrophobic pocket of MIF, which houses its specific tautomerase enzymatic activity, and demonstrate that targeting this unique active site significantly attenuates lung cancer growth in in vitro and in ...
7
Pocket PC User’s Guide
... your Pocket PC and catch the bus just in ...your Pocket PC up-to- date, you leisurely review your task list, make notes about the new books and CDs you want to buy, and read and respond to e-mail ...
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Becoming Lean pocket guide
... The event begins with a management commission The current process is mapped using standard conventions Data about the current process is checked to ensure full understanding Options for [r] ...
28
Host Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies
... The hydrophobic trough exposed on GP1 upon endosomal cleavage is the primary binding site of NPC1 domain ...the hydrophobic trough to better define its precise ...the hydrophobic trough had only ...
11
Virtual Screening for Novel HIV-Reverse Transcriptase Inhibitors
... Pay-mol software was used to find out the orientation and binding pocket of the enzyme molecule. It is shown that there are more polar bonds of this ligand with enzyme residues then navaprine. Its interaction with ...
5
Complex Formation Of Chromium (Vi) With 2-Hydroxy-5-Bromothiophenol In The Presence Of Di - And Triphenylguanidine
... of hydrophobic amines, these compounds are extracted into the organic phase in the form of a mixed-ligand ...the hydrophobic amines, diphenylguanidine and triphenylguanidine were ...
14
Journal of Applied Pharmaceutical Science
... This is based on the interfacial disposition of a polymer following displacement of a semi-polar solvent miscible with water from a lipophilic solution. This method involves the use of an organic phase, which is ...
9
Pocket User Guide
... Dial the directory number (outside line number or Extension number) to con- nect or you can press the outside line button or Feature/DSS button of the out- side line/extension to be conn[r] ...
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Pocket PC Phone
... • While walking with a colleague, your Pocket PC Phone rings. You look at the caller ID and see your manager is calling. She asks if you two are free this afternoon for an emergency meeting. While your colleague ...
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