Hydroxyl Propyl Methyl Cellulose

Top PDF Hydroxyl Propyl Methyl Cellulose:

INTEND, DEPICTION IN VITRO AND IN VIVO APPRAISAL OF GLIPIZIDE FLOATING MICROSPHERES USING ETHYL CELLLULOSE AND HYDROXYL PROPYL METHYL  CELLULOSE AS POLYMER BY SUBSTANTIALLY MODIFIED METHOD

INTEND, DEPICTION IN VITRO AND IN VIVO APPRAISAL OF GLIPIZIDE FLOATING MICROSPHERES USING ETHYL CELLLULOSE AND HYDROXYL PROPYL METHYL CELLULOSE AS POLYMER BY SUBSTANTIALLY MODIFIED METHOD

Floating microspheres were prepared by solvent evaporation methods using hydroxyl propyl methyl cellulose (HPMC) and ethyl cellulose (EC) as polymer and constant solvent ratio. Various formulations of microspheres were prepared using gradually increase EC concentration. Total eight batches of microspheres were prepared in two groups, which were shown in Table 3. In First group, four batches were prepared with drug:EC ratio and in second group other four batches were prepared with drug:HPMC:EC ratio.

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DESIGN, DEVELOPMENT AND CHARACTERIZATION OF LOVASTATIN TRANSFERSOMAL LOADED GELS FOR TRANSDERMAL DRUG DELIVERY

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF LOVASTATIN TRANSFERSOMAL LOADED GELS FOR TRANSDERMAL DRUG DELIVERY

in 95:5, 92.5:7.5, 90:10 ratios shown drug diffusion for a period of 16 hours, 18 hours, and 20 hours respectively. With a view to design a prolonged release dosage form, various types of gel formulations were prepared using polymers like methyl cellulose, sodium carboxy methyl cellulose and hydroxyl propyl methyl cellulose. Lovastatin Transfersomes prepared with Soya Lecithin: Tween 80 in 90: 10 ratio were incorporated in those formulations and subjected to diffusion study. The gels prepared with the methyl cellulose, sodium carboxy methyl cellulose, and hydroxy propyl methyl cellulose shown drug diffusion for a period of 20.4 hours, 22 hours and 24 hours respectively. The hydroxyl propyl methyl cellulose gels prepared using the ratio of Soya Lecithin: Tween 80 in 90: 10 ratio were selected for the prolonged and controlled therapeutic efficacy. The correlation coefficient values (r) were shown in table 3 and revealed that the diffusion profiles followed zero order kinetics and mechanism of drug diffusion followed by peppas model. The diffusional exponential coefficient (n) values were found to be in between 0.8527 to 0.8750, indicating that the drug diffusion followed non fickian diffusion mechanism.
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“Gelatin-Based Nanoparticles as Drug Delivery System of Lornoxicam Gel” by EL- Assal M. I. A., Egypt.

“Gelatin-Based Nanoparticles as Drug Delivery System of Lornoxicam Gel” by EL- Assal M. I. A., Egypt.

The purpose of contemporary study was to project GNP by using of two step desolvation method. Biodegradable hydrophilic gelatin nanoparticles used as a delivery system of anti-inflammatory lornoxicam after gel formulation using each of hydroxyl propyl methyl cellulose (HPMC) and carbopol as gelling agent. The size and shape of the nanoparticles were examined by optical microscope and transmission electron microscopy, particles with a mean diameter of 240.6 nm and 0.1 poly dispersibility index PDI were produced and the percentage of entrapment efficiency was found to be 87.1%. The optimum amount of LOR loading was obtained. Four formulas were prepared F1, F2 are slandered drug gel and F3 and F4 are GNP-LOR gel. Permeation of drug through membrane was determined by Franz diffusion cell. Further stability studies were carried out at 4°C for a period of 8 weeks. Vivo study was carried on white albino male rats to compare between different lornoxicam gel formulations. Results show that the two step desolvation is an appropriate method for preparing GNP as a delivery vehicle for LOR gel which gives sustained drug release. LORF3 which has carbopol as gelling agent was of lower release rate as regard carbopol was found to be a good choice for formulating LOR as topical formulation.
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Effect of Sourdough and the Addition of Hydroxy Propyl Methyl Cellulose Gum on the Sensorial Attributes and Shelf Life of Barley Bread

Effect of Sourdough and the Addition of Hydroxy Propyl Methyl Cellulose Gum on the Sensorial Attributes and Shelf Life of Barley Bread

The study of the comparison between means shows that there is a significant difference in the 5% of level in treatment. By increase of gam percentage, the dough stability will also increase. So that the most amount of dough stability is related to the treatment which is provided of 3% of gam (4.8 minutes) and the least amount of dough stability is about treatment that is prepared of 0% gam (3.3 minutes). As it can be seen in Table 2, there is no significant difference in the level of 5% between prepared treatments of 1.5% and the one of 0%. The time of flour expansion and its stability indicates the flour’s power and the higher amount shows more powerful flour. Kadan and his co-workers (2001) discovered that the hydroxyl propyl methyl Cellulose cause the improvement of gas maintenance and water absorption and in this way it acts like the Gluten and increase the flour stability.
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OPTIMIZATION AND EVALUATION OF METOCLOPRAMIDE HCl AS MUCOADHESIVE BUCCAL PATCH

OPTIMIZATION AND EVALUATION OF METOCLOPRAMIDE HCl AS MUCOADHESIVE BUCCAL PATCH

Buccal drug delivery appeared as an innovative substitute to other conventional types of drug delivery systems. Within the oral mucosal cavity, the buccal region has rich blood supply and relative permeability that offers an attractive route for drug administration into the systemic circulation. This study involved formulation of metoclopramide HCl as bilayer mucoadheive buccal patch composed of medicated layer and backing layer to prevent undesirable drug release by utilizing solvent casting technique. The medicated layer was prepared by using hydroxyl propyl methyl cellulose as primary polymer and different secondary polymers including poly vinyl pyrolidone, Carpabol and sodium carboxy methyl cellulose in order to optimize the final formula. The backing layer was prepared by using ethyl cellulose and dibutyl phthalate as plasticizer. The results revealed that formula F4 containing hydroxyl propyl methyl cellulose (75mg) as primary polymer and poly vinyl pyrolidone (18.75 mg) as secondary polymer, propylene glycol as plasticizer (30% of total polymer weight), sodium saccharine as sweetening agent (4 mg) was chosen as selected formula in accordance to the surface pH (6.82), tensile strength (15.34), percentage elongation at break (26.75), swelling index (18.64), mucoadhesive strength (19.23gm), percentage moisture absorption (5.35), percentage moisture loss (4.81) and Ex-Vivo residence time (6.23hrs) which is satisfactory to give invitro release (92.34%) of metoclopramide HCl after 6 hrs. The research showed invivo drug release of 69.54% for selected formula, with invitro- invivo correlation equal to (0.9822) suggesting successful formulation that can be
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DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHES FOR IMPROVED IN-VITRO PERMEATIONOF FESOTERODINE

DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHES FOR IMPROVED IN-VITRO PERMEATIONOF FESOTERODINE

The present investigation was taken up to prepare and evaluate a trans- dermal drug delivery system of Fesoterodine to increase its bioavailabil- ity. The matrix type patches were prepared using polymers such as HPC, Hydroxyl Propyl Methyl Cellulose (HPMC E15CPS, HPMC E50CPS) by solvent casting method and to study the effect of polymer composition, plasticizer and permeation enhancer on the physico-mechanical and in- vitro drug release characteristics of the film. Propylene glycol and DMSO were used as plasticizer and permeation enhancer respectively. Incorpora- tion of Propylene glycol improved the flexibility, folding endurance and handling properties of the patches. Increasing the concentration of plasti- cizer and the presence of DMSO were found to increase the in vitro drug release of the patches. The presence of DMSO produced significant in- crease in the flux and permeability constant. The formulation with HPC, DMSO as permeation enhancer and propylene glycol as plasticizer showed the best results which exhibited the cumulative percentage of drug release of 95% in 8 hrs. Drug-excipients interaction studies were carried out using IR technique; patches indicated no chemical interaction between drug and excipients. The results of the skin irritation studies showed no noticeable irritancy on rabbit skin indicating the skin compati- bility of the drug as well as polymer.
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MATRIX TABLET OF RASAGILINE MESYLATE: AN APPROACH FOR THE TREATMENT OF   PARKINSON DISEASE Reshu Virmani*, Tarun Virmani, Charan Singh1, Geeta SoroutDOWNLOAD/VIEW

MATRIX TABLET OF RASAGILINE MESYLATE: AN APPROACH FOR THE TREATMENT OF PARKINSON DISEASE Reshu Virmani*, Tarun Virmani, Charan Singh1, Geeta SoroutDOWNLOAD/VIEW

Parkinson’s disease is a common neurodegenerative disorder that can cause significant disability and decreased quality of life. It is a multidimensional disease and management needs to be holistic, incorporating the patient and family, utilizing a multidisciplinary team and addressing both medical as well as rehabilitation issues from diagnosis to advanced disease. In the present study, sustained release tablets of Rasagiline mesylate is designed using xanthan gum (XG), and hydroxyl propyl methyl cellulose K 100 M (HPMC) as release retarding polymers alone or in combination as Rasagiline is a better alternative and considered as drug of choice for effective treatment of Parkinson’s disease with reduced side effects. Tablets were formulated in nine batches by using different ratios of drug and excipients. The drug release profiles of various formulations showed that these were successful in effectively sustaining the drug release from the matrix tablets, as set in objectives.
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FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM CONTAINING DOMPERIDONE AND PARACETAMOL

FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM CONTAINING DOMPERIDONE AND PARACETAMOL

Evaluation of Pulsatile Release Tablet: The optimized formulation was coated with both polymers hydroxyl propyl methyl cellulose and ethyl cellulose respectively with different weight ratios (150:0, 120:30, 75:75, 30:120, 0:150w/w). The % CDR was given. The pulsatile tablets of Domperidone and Paracetamol were subjected to post compression analysis. The tablets were prepared by direct compression method. The hardness of the tablets prepared by direct compression method was determined by using Monsanto Hardness tester. The mean thickness of core tablets was (n=3) found within the range of 5.14 – 6.02 mm for the pulsatile tablets as shown in Table 4. The drug content uniformity of all formulations was carried out and was found to be within the range 94.12 % to 99.01 %. As shown in Table 5.
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Formulation and Evaluation of Sustained Release Matrix Tablet  of Loroxicam

Formulation and Evaluation of Sustained Release Matrix Tablet of Loroxicam

The present study relates to formulation and evaluation of sustained release matrix tablet of Lornoxicam. Lornoxicam, a potent non- steroidal anti-inflammatory drug of oxicam class. Lornoxicam as a non- steroidal anti-inflammatory drug, its use in relieving the symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and low back pain. However due to its weak acidic nature, its release from SR delivery system is limited to lower gastrointestinal tract which consequently leads to delayed onset of its analgesic action. Lornoxicam sustained release tablet was prepared by using polymers Hydroxyl Propyl Methyl Cellulose K100 as sustained release polymer and Polyvinylpyrrolidone, Hydroxyl Propyl Methyl Cellulose K30 as binder by direct compression method. A 3 2 full factorial design was used to formulate different batches containing different concentration of Hydroxyl Propyl Methyl Cellulose K 100 and Polyvinylpyrrolidone K30. The prepared tablets were evaluated for different parameters like Hardness, Friability, and Dissolution. Response surface plots and counter plots were generated using Design Expert software version 10, the optimized formulation was achieved by numerical and graphical optimization. Out of all factorial design batches F7 batch shows sustained release drug release for 24hr as compared to other all batches.
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Development of Preparation Method for  Microencapsulating Uycalyptus Oil  Containing Fine Aqueous Droplets by Use of Interfacial Condensation Reaction between Hydroxy Propyl Methyl Cellulose and Tannic Acid

Development of Preparation Method for Microencapsulating Uycalyptus Oil Containing Fine Aqueous Droplets by Use of Interfacial Condensation Reaction between Hydroxy Propyl Methyl Cellulose and Tannic Acid

It was tried to develop the preparation method for microencapsulating the uycalyptus oil con- taining fine aqueous droplets by using the interfacial condensation reaction between hydroxyl propyl methyl cellulose and tannic acid. Uycalyptus oil containing fine aqueous droplets was dis- persed in the continuous water phase to form the (W/O)/W emulsion. Tannic acid and hydroxyl propyl methyl cellulose were dissolved in the inner aqueous droplets and in the outer continuous water phase, respectively. Tannic acid transferred through the oil phase from the inner water droplets to the interface between the oil phase and the continuous water phase and then, reacted with hydroxyl propyl methyl cellulose. In the experiment, the concentrations of hydroxyl propyl methyl cellulose and tannic acid were mainly changed stepwise. The uycalyptus oil containing the fine water droplets could be microencapsulated satisfactorily. It was found that the microcapsules were composed of the gelated hydroxyl propyl methyl cellulose film as the shell, the fine aqueous droplets as the first core and the oil droplet as the second core.
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 FABRICATION OF PULSATILE DELIVERY MULTIPARTICULATE SYSTEM OF POORLY WATER SOLUBLE CARVEDILOL PHOSPHATE

 FABRICATION OF PULSATILE DELIVERY MULTIPARTICULATE SYSTEM OF POORLY WATER SOLUBLE CARVEDILOL PHOSPHATE

Carvedilol phosphate (CP) from Cadila Pharmaceuticals Ltd. Ahmadabad, India; Sugar spheres (Pharma-a-spheres 20/25) from Hanns G. Werner GmbH, Germany; Ethyl cellulose (Ethocel standard 10 and standard 100) from Colorcon Asia Pvt. Ltd. Goa, India; Hydroxy propyl methyl cellulose (HPMC, Methocel E6 premium) from Colorcon Asia Pvt. Ltd. Goa, India; Crospovidone (Polyplasdone XL-10) from Ashland Specialty Ingredients, USA; Sodium starch glycolate (Glycolis) from Roquette freres, France; Low-substituted hydroxyl propyl cellulose from Shin-Estu Chemical Company Ltd., Japan; Polyoxyl hydrogenated castor oil (Chemosphere RH 40) BASF, Germany and Dibutyl sebacate from Morflex Inc, Greensboro, USA were received as gift samples. Methanol and Methylene chloride were of analytical grade.
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 DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF NIMODIPINE

 DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF NIMODIPINE

The order of increasing release rate observed with various mucoadhesive microcapsules of Nimodipine with sodium alginate – methyl cellulose < Sodium Alginate – Carbopol < Sodium Alginate – Sodium CMC < Sodium Alginate – HPMC. In conclusion, Sodium Alginate – Methyl Cellulose and Sodium Alginate – Carbopol 934 microcapsules could be used for sustained action for over long period of time. However, further In-vivo studies are needed to optimize for sustained action in human beings for their better efficacy and safety.
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Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies

Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies

Diclofenac sodium matrix tablets were prepared by mixing the ingredients previously passed through sieve No. 100 sufficient for a batch of 200 tablets weighed according to the formulas shown in Table 1 to 3. The drug was geometrically mixed with polymer (xanthan gum/hydroxy propyl methyl cellulose) until a homog- enous blend was achieved. 2 % w/v xanthan gum dispersion in water was used as granulating agent for preparation of xanthan gum matrix tablets respectively. 5 % w/v poly vinyl pyrrolidone (PVP) in ethanol was used as granulating agent for the preparation of hydroxy propyl methyl cellulose matrix tablets. Granules were prepared by passing mass initially through sieve No. 12 (nominal mesh aperture size 1.4 mm and approximate % sieving area 44) and dried at 50 °C in hot air oven. Dried granules passed through sieve No. 22 (nominal mesh aperture size 710 µm and approximate % sieving area 37). Granules of compritol were made by hot melt granulation method. Compritol was melted in a porcelain dish on a water bath at 75 °C for 3 min. Diclofenac sodium was added gradually with stirring until uniformly mixed. The molten mixture was allowed to cool slowly while stirring and solidify at room temperature. The solidified mass was crushed in mortar and passed through a sieve No. 22. Then granules were lubricated with magnesium stearate and talc and blended for 3 min in polybag. All granules made with different polymers showed good flow characters. Hence, the final blend was compressed into tablets on a 16-station rotary punching machine (M/s. Cadmach Machinery Co. Pvt. Ltd., India) using 8 mm or 10 mm round flat punches with compression force sufficient to obtain hardness of 4 to 5 kg/cm 2 .
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FORMULATION AND EVALUATION OF CONTROLLED RELEASE TABLETS OF PIOGLITAZONE 	 Rama Kotaiah Mogili*, Ram Babu. G, Prasad Rao.M, Lakshman.PDOWNLOAD/VIEW

FORMULATION AND EVALUATION OF CONTROLLED RELEASE TABLETS OF PIOGLITAZONE Rama Kotaiah Mogili*, Ram Babu. G, Prasad Rao.M, Lakshman.PDOWNLOAD/VIEW

Pioglitazone Controlled release tablets were prepared by using polymers like Hydroxy propyl methyl cellulose, Psyllium, Guar-gum, Xanthum gum and Carbopol. From this study it can be concluded that Pioglitazone C.R tablets prepared by Hydroxy propyl methyl cellulose K15M ( i.e. H3) showed good release rate than the tablets prepared by using other polymers. Pre compression and Carr’s index of the pure drug indicated that the drug had good flow property, even the formulations were found to be within the range. Post compression studies, for tablets like thickness, diameter, hardness, friability, drug content uniformity was done. The dissolution studies were carried out for 24 hours. As per the result of dissolution study of formulation H3, P3, G3 and X3 showed reasonable release 99.87%, 97.85%, 92.48% and 93.51% respectively at the end of 24hrs. Formula H3 showed good drug release profile 99.87% at the 24 hrs, showed excellent matrix integrity during the period of study, when compare to other formulations. The formulation H3 was considered optimum because it showed negligible drug release in acidic medium and drug release in the phosphate buffer (pH 7.4) was found to be almost complete. The stability studies of the selected formulation showed that the product was stable through-out the study period .
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Formulation and Evaluation of Floating Microparticles of Amlodipine Besylate

Formulation and Evaluation of Floating Microparticles of Amlodipine Besylate

Hydro dymamically balance system (HBSTM) was first design by Sheth and Tossounian in 1975.Such systems contains drug with gel forming hydrocolloids meant to remain buoyant on stomach contents. This system incorporate a high level of one or more gel forming highly swellable cellulose type hydrocolloids. e.g. HEC, HPMC, NaCMC, Polysacchacarides and matrix forming polymer such as polycarbophil, polyacrylates and polystyrene, incorporated either in tablets or in capsule. On coming in contact with gastric fluid, the hydrocolloid in the system hydrates and forms a colloidal gel barrier around the gel surface. The air trapped by the swollen polymer maintains a density less than unity and confers buoyancy to these dosage form.
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FORMULATION AND EVALUATION OF MITIGLINIDE GASTRO RETENTIVE DRUG DELIVERY SYSTEM

FORMULATION AND EVALUATION OF MITIGLINIDE GASTRO RETENTIVE DRUG DELIVERY SYSTEM

alcohol and NaHCO3) on drug release were determined. The sixteen formulations of optimization phase were categorized into five groups for ease of analysis as Group I, Group II, Group III, Group IV and Group IV by changing all variable at different levels. Parameters of evaluation are such as angle of repose, density, compressibility index, hausner’s ratio and primary evaluation parameters of such as thickness, hardness, friability, weight variation and swelling index. The angle of repose of F1 and F4 were highest and lowest for 28.38º and 24.02º respectively. The bulk density id highest for F9 and lowest for F11, while the Carr’s index is highest for F4 and lowest for F15, indicating that low value has the highest compressibility. Highest content was loss on friability test for F9.Hardness is highest for F10 and lowest for F11. Swelling index is more observed for F16 as a best formulation and these differences were insignificant and the best retards formulation was optimized by factorial plots and it has the swelling ration of 22.81 for F16 formulation. The floating abilities of single tablets were determined in 400mL of 0.1N Hcl. The drug release studies were carried out using dissolution media 0.1N Hcl buffer pH 1.2 at 235nm. The results clearly indicate that the content as well as the release of mitiglinide from the tablets is strongly affected by the variables selected for the study. The main effects of A, B, C, and D represent the average result of changing one variable at a time from its low level to its high level. The interaction terms (AB, AC, AD, BC, BD, CD, ABC, ABD, ACD, BCD, and ABCD) show how the dependent variables change when two, three and four independent variables are simultaneously changed. Keywords: Mitiglinide, Gastro retentive drug delivery system, In vivo studies, HPMC, Ethyl cellulose.
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“Improvement in the Physical and Chemical Stability of Gabapentin by Using Different Excipients” by Ranjous, Y., Hsian, J, Syria.

“Improvement in the Physical and Chemical Stability of Gabapentin by Using Different Excipients” by Ranjous, Y., Hsian, J, Syria.

The aim of this study was to investigate the best stable mix for gabapentin with excipients which have different physiochemical properties under different ambient conditions. Gabapentin undergoes intramolecular cyclization by nucleophilic attack for alkyl amine on carboxylate carbonyl followed by dehydration, so gabapentin needs special conditions of temperature and relative humidity during manufacturing and storage, because gabapentin turns to gabapentin lactam which has toxic effect. Mixtures of gabapentin with each of the following excipients were made: PVP K15, Aerosil K100, Avicel pH101, Mg stearate, hydroxy propyl methyl cellulose (HPMC) were used and milled for five minutes by porcelain mortar and pestle, then the mixtures were kept in open glass containers which kept in desiccators containing different saturated salt solutions to reach the required relative humidity, these desiccators were kept in dry oven to get the required temperature, the samples were withdrawn to analyze for intact gabapentin by high performance liquid chromatography (HPLC) at zero moment (directly after milling) and after the first, second, third, fourth and fifth week. Also sample of raw gabapentin milled for 5 minutes was analyzed to investigate the effect of milling on stability. The best recovery of intact gabapentin was obtained at high relative humidity and low temperature with gabapentin:mg stearate (1:5%) mixture, so it is useful to use this conditions during manufacturing and storage of gabapentin.
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DESIGN AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEMS OF ANITDIABETIC DRUG-BUFORMIN

DESIGN AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEMS OF ANITDIABETIC DRUG-BUFORMIN

Accurately weighed buformin was first mixed with polymers and sodium bicarbonate, citric acid, and microcrystalline cellulose were mixed to form homogenized mass, and on constant mixing it was added to cetyl alcohol previously melted at 45 0 C to ensure homogenous mass. The wet damp mass was screened to form granules by 22# mesh. The granules were kept under 45 0 C for drying. The dried granules were lubricated with magnesium stearate towards the final mixture. The final blend was then pressed by using Proton R&D ten station tablet press. The first step was to develop a single unit gas-generating gastroretentive dosage form for buformin. As buformin was a water soluble drug, for the controlling of drug release from the dosage form, the hydrophilic swellable polymers should be added 5, 6 .
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The application of biomedical polymer material hydroxy propyl methyl cellulose(HPMC) in pharmaceutical preparations

The application of biomedical polymer material hydroxy propyl methyl cellulose(HPMC) in pharmaceutical preparations

High-viscosity grades may be used to retard the release of drugs from a matrix at levels of 10–80% w/w in tablets and capsules. Low-viscosity grades as the channel agents used in sustained and controlled release preparations, the therapeutic effect of this kind of tablet for initial dose can be reached quickly and drug sustained or controlled re- lease, thus effective blood concentrations are maintained in the body. HPMC under water after hydration gel layer formation, the release mechanism of drugs from the skeleton mainly include the spread and corrosion of the gel layer. Jung Bo Shim[18] used HPMC as sustained-release material for preparation of carvedilol sustained-release tablet. Currently, HPMC sustained-release skeleton is a large number of applications in traditional Chinese medicine, especially in Chinese medicine effective component, effective parts and single preparations. Liu Wen[19] use 15% HPMC as sustained-release material, 1% lactose and 5% microcrystalline cellulose as filler to prepared Hetaocheng- qitang into oral framework sustained-release tablets. Tang Guanguang[20] adopt astragaloside as model medicine to prepare HPMC framework tablet, and discuss the factors of affecting Chinese medicine effective parts of drug re- lease. With increase content of HPMC and the release of astragalus saponin is reduced, there is a linear relationship between the release centigrade of the drug and corrosion degree of skeleton, so as the hydrophilicity chemical mo- nomer. HPMC is not only to the hydrophilic compounds, and is suitable for the hydrophilic of material.Liu Gui- hua[21,22] adopt 17% HPMC K15M as sustained-release framework to prepare Saussurea involucrate Gel sustained-
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 FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL SYSTEM OF LISINOPRIL DIHYDRATE

 FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL SYSTEM OF LISINOPRIL DIHYDRATE

Lisinopril is a drug of class angiotensin converting enzyme (ACE) inhibitor that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. If it is given orally, there may be severe hepatic first pass metabolism as a result there is reduction in the bioavailability (6-60%). In order to increase the bioavailability of the lisinopril, transdermal films were formulated using different polymer combinations such as hydrophilic (hydroxy propyl methyl cellulose: poly vinyl pyrrolidone) and combination of lipophillic- hydrophilic polymers (ethyl cellulose: poly vinyl pyrrolidone) in different ratios. The prepared films were evaluated for thickness, folding endurance, drug content uniformity, tensile strength, percent moisture uptake, percent moisture loss, in-vitro skin permeation study. In-vitro drug release study through sigma membrane indicated that hydrophilic polymer combinations have shown greater drug release than the hydrophilic-lipophillic polymer combinations. By fitting the data into zero order, first order and Higuchi model, it was concluded that drug release from matrix films followed Higuchi model and the mechanism of release was diffusion mediated.
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