Hypercalcemia of malignancy
Refractory hypercalcemia of malignancy related to vitamin D toxicity: Treatment strategies
... Introduction: Hypercalcemia of malignancy (HCM) is a known cancer complication resulting in morbidity and ...The hypercalcemia was refractory to standard treatments including intravenous ...
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Denosumab Use in a Patient with Bisphosphonate-Resistant Humoral Hypercalcemia of Malignancy
... (1) Malignancy-associated hypercalcemia is the most common cause of hypercalcemia in hospitalized patients and is a predictor of a poor prognosis with an approximately 50% mortality rate within 30 ...
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Hypercalcemia of malignancy and new treatment options
... Abstract: Hypercalcemia of malignancy affects up to one in five cancer patients during the course of their ...of hypercalcemia are generally constitutional in nature and not specific to the inciting ...
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Identification of transcripts encoding a parathyroid hormone like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy
... humoral hypercalcemia of malignancy (HHM) appears to be mediated in many instances by a parathyroid hormone-like peptide, which has recently been purified, sequenced, and ...
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Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy
... humoral hypercalcemia of malignancy (HHM) is caused by tumor cells that release a circulating factor which stimulates osteoclastic bone ...that hypercalcemia is due to bone resorbing factors ...
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Tumor products and the hypercalcemia of malignancy
... Introduction One of the most interesting aspects of the hypercalcemia of malignancy is that it is unlikely that the hypercalcemia is due to the secretion by the tumor cells of one gene p[r] ...
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In vitro adenylate cyclase stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice
... A number of factors have been proposed as potential mediators of the syndrome of humoral hypercalcemia of malignancy (HHM), but to date no firm cause-and-effect relationship has been established. We ...
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Prevalence of hypercalcemia of malignancy among pediatric cancer patients in the UK Clinical Practice Research Datalink database
... Hypercalcemia of malignancy (HCM) occurs among people with cancer and is the result of bone resorption, which leads to raised calcium levels in the blood. The reported proportion of cancer patients who ...
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Hypercalcemia of malignancy revisited
... These advances include discovery and characterization of the PTH-related protein PTH-rP' produced by many solid tumors, demonstration of tumor-derived transforming growth factor-alpha TG[r] ...
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THE SEPARATE EFFECTS OF HYPERPARATHYROIDISM, HYPERCALCEMIA OF MALIGNANCY, RENAL FAILURE, AND ACIDOSIS ON THE STATE OF CALCIUM, PHOSPHATE, AND OTHER IONS IN PLASMA
... acidosis, 3 hyperparathyroidism, and 4 hypercalcemia of other types, upon several parameters: 1 the percentage ionization of plasma calcium; 2 the ion product [Ca2+] X [HPO42-]; 3 the ab[r] ...
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Humoral hypercalcemia of malignancy Release of a prostaglandin stimulating bone resorbing factor in vitro by human transitional cell carcinoma cells
... the hypercalcemia that occurs in patients with ...humoral hypercalcemia. These cells are tumorigenic and cause hypercalcemia in athymic nude ...
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Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells
... The culture media of three cell lines, a human prostate carcinoma PC3, a rat Leydig cell tumor Rice-500, and a rat carcinosarcoma WRC-256, that were derived from tumors associated with h[r] ...
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Cholangiocarcinoma Presenting with Hypercalcemia and Thrombocytopenia
... Malignant hypercalcemia and thrombocytopenia may result from bone metastasis of cholangiocarcinoma ...showed hypercalcemia and ...of hypercalcemia of malignancy with elevated calcium levels ...
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Bisphosphonates: Benefits, Basics, Potential Dental Side Effects, and Management
... Bisphosphonates are compounds used in the treatment of many skeletal disorders, such as bone metastases, osteoporosis, Paget’s disease, hypercalcemia of malignancy, and bone pain. Bisphosphonates have been ...
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An unusual case of malignancy-related hypercalcemia
... of malignancy resulting from ectopic produc- tion of PTH, although not common, should be considered when PTH levels are significantly elevated and there is no evidence of a parathyroid-related ...of ...
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Multiple myeloma/hypercalcemia
... myeloma-associated hypercalcemia is, by and large, successful elimination of the primary tumor, but myeloma remains an incurable cancer and its unique propensity to cause bone destruction is, in part, responsible ...
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Bisphosphonates for Treatment of Childhood Hypercalcemia
... This 5-year-old female presented with a history of irritability, fatigue, polydipsia, nocturia, and joint pain. She was found to have hypercalcemia of unknown etiology (calcium of 17.3 mg/ dL), along with a normal ...
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Asymptomatic Neonatal Familial Hypercalcemia
... In the context of subsequently well docu- mented familial hypocalciuric hypercalcemia, Spie- gel et al’4 and Marx et al2’ described an infant with severe neonatal hyperparathyroidism in [r] ...
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Study of risk of malignancy index in the Preoperative evaluation of patients with ovarian tumor
... of malignancy is high and should be properly investigated and the probability of malignancy should be ...of malignancy such as breast cancer, colon cancer, ovarian cancer should be elicited , as 10% ...
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On the Mechanism of Hyposthenuria in Hypercalcemia
... The micropuncture data obtained from the papilla of hypercalcemic hamsters do not support the view that the collecting ducts develop a selective impermeability to water since no consiste[r] ...
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