Hypoxia and Metastasis
The impact of hypoxia in pancreatic cancer invasion and metastasis
... Dovepress Hypoxia and pancreatic cancer Sensing and responding to hypoxia The main molecular mechanism by which oxygen homeostasis is maintained in tissues is regulated by the hypoxia-inducible ...
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Hypoxia-regulated target genes implicated in tumor metastasis
... of hypoxia-induced metastasis is that hypoxia induces various transcriptional regulators (also called EMT regulators) to cause EMT ...by hypoxia through the lysyl oxidase-like 2 enzyme ...
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Hypoxia, partial EMT and collective migration: emerging culprits in metastasis
... with hypoxia. Hypoxia-driven activation of HIF-1α can drive ...cyclic hypoxia, as compared to acute or chronic hypoxia, shows the highest levels of active HIF-1α and can augment cancer ...
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The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
... chronic hypoxia often with dif- ferent biological consequences was thoroughly ...acute hypoxia is an abrupt and brief exposure to short-term hypoxia which occurs when blood vessel occlusion lasts for ...
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Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis
... ABSTRACT Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient prognosis, tumor cell migration, invasion and ...that hypoxia alters endosome dynamics in tumor cells, ...
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Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma
... that hypoxia microenvironment may play an essential role in regulating VASP; however, until now, the potential role of VASP in HCC metastasis and invasion and its relationship with hypoxia remain ...
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Hypoxia-Inducible lncRNA-AK058003 Promotes Gastric Cancer Metastasis by Targeting γ-Synuclein
... a hypoxia-responsive lncRNA and is essential for hypoxia- enhanced glycolysis ...potential hypoxia-responsive lncRNAs using lncRNA microarrays between hypoxia-induced GC cells and ...
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Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis
... and metastasis depends on oxy- gen ...and metastasis was analyzed by the same in vivo assays described above for wild-type ...reducing hypoxia — protect cancer cells against oxidative ...
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Rectal Cancer – Functional Molecular Profiling and Targeting of Tumor Hypoxia in Radiation Response and Metastasis
... The recently completed prospective phase II trial, the LARC-RRP study, offers a unique opportunity to explore the concept of tumor hypoxia as a determinant of metastatic behavior in a defined clinical context. ...
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MicroRNA 18a inhibits hypoxia inducible factor 1α activity and lung metastasis in basal breast cancers
... lung metastasis, whereas miR-18a inhibition in the parental cells promoted tumor growth and lung ...and hypoxia in vitro in a HIF1A-dependent ...distant metastasis through a HIF1A-dependent ...
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14-3-3ζ promotes hepatocellular carcinoma venous metastasis by modulating hypoxia-inducible factor-1α
... intrahepatic metastasis arising from hepatocellular carcinoma (HCC) and is highly correlated with a poor ...prognosis. Hypoxia is common in solider tumors, including HCC, where it alters the behavior of HCC ...
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Hypoxia inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
... Intratumoral hypoxia promotes metastasis through activation of hypoxia-inducible factors ...BCC metastasis to LNs and lungs in a HIF-dependent ...promoted metastasis of BCCs and also ...
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<p>c-Src is required for hypoxia-induced metastasis-associated functions in prostate cancer cells</p>
... and hypoxia and its associated molecular markers, such as HIF-1 α ...tumor hypoxia in ...and metastasis, suggesting it as an upstream regulator of ...
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Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells.
... to hypoxia and nutrient deprivation through the induction of HIFs, glycolytic pathways and autophagy may result in their enhanced expression of pluripotency-associated molecules and acquisition of a more ...
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Hypoxia-inducible factor dependent breast cancer mesenchymal stem cell bidirectional signaling promotes metastasis
... Intratumoral hypoxia promotes metastasis through activation of hypoxia-inducible factors ...BCC metastasis to LNs and lungs in a HIF-dependent ...promoted metastasis of BCCs and also ...
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Tumor Interstitial Fluid Pressure—A Link between Tumor Hypoxia, Microvascular Density, and Lymph Node Metastasis
... tumor hypoxia is primarily a consequence of poor oxygen supply caused by an inadequate vasculature with increased intervessel ...central hypoxia, and lymph node metastasis was associated with high ...
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Hypoxia induced overexpression of stanniocalcin 1 is associated with the metastasis of early stage clear cell renal cell carcinoma
... and metastasis of ...the metastasis of early stage ccRCC by regulating the proliferation, cell cycle, mi- gration and invasion of tumor ...outcome. Hypoxia and HIF-1α were identified as candidate ...
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CDK inhibitors reduce cell proliferation and reverse hypoxia-induced metastasis of neuroblastoma tumours in a chick embryo model
... of hypoxia-treated tumours with and without CDK1i revealed that CDK1i reversed the observed upregulation of expression in the seven up-regulated genes whilst VCAN, whose expression was down-regulated showed a ...
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Inhibition of Raf MEK ERK and Hypoxia pathways by Phyllanthus prevents metastasis in human lung (A549) cancer cell line
... Results: Phyllanthus was observed to cause antimetastatic activities by inhibiting ERK1/2 pathway via suppression of Raf protein. Inhibition of this pathway resulted in the suppression of MMP2, MMP7, and MMP9 expression ...
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Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea
... Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of ...tumor metastasis is accelerated by OSA-like IH remain to be ...
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