Hypoxic response
HER2 regulates HIF 2α and drives an increased hypoxic response in breast cancer
... in response to hypoxia, with no discernible effect on ...hypoxia response genes in a 3D model which recapitulates the oxy- gen gradient seen in the tumour ...the hypoxic expression of various ...
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Modeling the Transcriptional Regulatory Network That Controls the Early Hypoxic Response in Candida albicans
... transcriptional response to hypoxia. We also profiled the hypoxic response in ⌬tye7 mutants as well as in cells missing the Ahr1 transcription factor, which has been shown previously to bind to and ...
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Regulation of the Hypoxic Response in Candida albicans
... the hypoxic response appears to be as an activator of ...genes, hypoxic induction is therefore not signaled via the lowering of sterol levels and is not depen- dent on UPC2 ...by hypoxic ...
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Hereditary aspects of decreased hypoxic response
... on hypoxic and hypercapnic ventilatory response, but it is unclear whether this influence is the result of hereditary or environmental ...ventilatory response to isocapnic hypoxia (HVR) and hyperoxic ...
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Correlation between Biofilm Formation and the Hypoxic Response in Candida parapsilosis
... the hypoxic profile of ...the response of cells growing in YPD medium at 30°C to facilitate a direct comparison with previously published results for ...
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Targeting hypoxic response for cancer therapy
... cell proliferation, survival, migration, and angiogenesis in hepatocellular carcinoma [71]. Furthermore, ADM is overexpressed in RCC [72] and in PDAC [73]). ILK is activated by HIF1A and through a regulatory loop it is ...
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Targeting hypoxic response for cancer therapy
... a response to hypoxia and nutrient deficiencies, cells activate angiogenesis, that is the development of new blood vessels sprouting from the existing ones ...essentially, hypoxic [7, ...
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Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation
... the hypoxic response identified changes between the two cell lines ...the hypoxic response of Vdac1 −/− MEF, including a lack of inhibition of cell proliferation, an increased oxidative stress ...
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Serotonergic system in hypoxic ventilatory response in unilateral rat model of Parkinson’s disease
... post- hypoxic respiration at chosen time points: 30s, 90s, 120 s, 150 s, 180 s and at 300 s (recovery after ...of hypoxic response in both neuro- logical states the data were expressed as % of ...
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Hif 1α paralogs play a role in the hypoxic ventilatory response of larval and adult zebrafish (Danio rerio)
... to hypoxic environments in the hypoxia-tolerant species that typify the cyprinid lineage (Rytkönen et ...the hypoxic response is a critical step in gaining insight into the significance of the ...
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Serotonergic and cholinergic elements of the hypoxic ventilatory response in developing zebrafish
... behavioural response to hypoxia was mediated by a serotonergic and cholinergic system (Regan et ...the hypoxic response initiated by O 2 chemoreceptors may include ...
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Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries
... within hypoxic capillaries were able to exert a dual level of control over microvascular autoregulation by 1) inhibiting ATP release [24] (the hypoxic ATP signal from the RBC) and/ or 2) inhibiting ...
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Responses of Japanese Soybeans to Hypoxic Condition at Rhizosphere Were Different Depending upon Cultivars and Ambient Temperatures
... stressed treatment the only low oxygen concentration, was aimed. For the purpose, the hydroponic cultural sys- tem was finally selected, it can remove the buffering ef- fect of the soil, and the differences in the ...
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Aged garlic extract and S-allylcysteine prevent apoptotic cell death in a chemical hypoxia model
... Under hypoxic conditions, mitochondrial complex III may produce ROS, and the presence of high ROS con- centrations generated from the mitochondria has been shown to stabilize HIF-1α ...
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Autophagic cell death participates in POMC induced melanoma suppression
... the mRNA level of HIF-1 α was only slight increased in α - MSH-treated cells in normoxia (Fig. 6a). Moreover, immunoblot and luciferase reporter assays have shown that α -MSH elevated the HIF-1 α -driven luciferase ...
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Hypoxic regulation of osteoclast differentiation and bone resorption activity
... in hypoxic osteoclasts, functional HIF-1 α -dependent pathways initially increase ATP production and bone resorption, but lack of activation of HIF-1 α -dependent survival pathways eventually results in cell ...
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Number of glioma polyploid giant cancer cells (PGCCs) associated with vasculogenic mimicry formation and tumor grade in human glioma
... the hypoxic microenvironment in tumor. The normal response to hypoxia is to stimulate the growth of new blood vessels and other blood supply ...by hypoxic condition ...The hypoxic ...
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Respiration in the African Lungfish Protopterus Aethiopicus
... On that basis it seems a significant finding that increased CO2 tension in the ambient water evokes a breathing response, whereas hypoxic water has no effect on the breathing pattern.. I[r] ...
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Effects of Sectioning Cranial Nerves IX and X on Cardiovascular and Ventilatory Reflex Responses to Hypoxia and Nacn in Channel Catfish
... However, the lack of a significant ventilatory response to either hypoxia or NaCN after total branchial denervation suggests that all hypoxic reflexes in channel catfish are mediated by [r] ...
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Time to Adopt Cooling for Neonatal Hypoxic-Ischemic Encephalopathy: Response to a Previous Commentary
... criteria for adopting hypothermia for neonatal hypoxic- ischemic encephalopathy (HIE) had not been met. They argued for a “conservative approach.” Clinicians who are “impressed” by their evidence are not mandated ...
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