i igf-i
Synergy Between Insulin-Like Growth Factor-I (igf-I) E-Peptides and Igf-I Signaling Alters Growth in Skeletal Muscle
... mature IGF-I and a carboxy- terminal extension called the ...mature IGF-I produced by both isoforms is identical, while EA and EB share less than 50% ...of IGF-I and its receptor ...
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Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis
... Another result which deserves particular mention is that iNOS expression was significantly lower in cirrhotic rats treated with IGF-I compared to untreated cirrhotic ani- mals. This finding is in accordance ...
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Human conditions of insulin like growth factor I (IGF I) deficiency
... circulating IGF-I levels are associated with neuro- logical recovery and a better functional outcome [339], probably due to its neuroprotective and pro-angiogenic ...of IGF-I was shown to ...
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Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth
... serum IGF-I and IGFBP-3 concentrations, and IGF-I/IGFBP-3 molar ratios observed during GH treatment has a number of ...serum IGF-I and IGFBP-3 within age dependent normal ranges ...
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Benefits of Recombinant Adeno-Associated Virus (rAAV)-Mediated Insulinlike Growth Factor I (IGF-I) Overexpression for the Long-Term Reconstruction of Human Osteoarthritic Cartilage by Modulation of the IGF-I Axis
... Delivery of candidate genes to articu- lar chondrocytes is an attractive strategy that has the potential to allow for a dura- ble reestablishment of the structural in- tegrity in OA cartilage. Gene transfer ap- proaches ...
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Circulating levels of insulin like growth factor I (IGF I) correlate with disease status in leprosy
... hormone IGF- I, previously shown to suffer a serious imbalance during infectious and inflammatory diseases ...the IGF system was ana- lyzed during the course of ...of IGF-I and IGFBP-3 ...
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Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
... that IGF-IR cooperates with the G-protein estrogen receptor (GPER) and the collagen receptor discoidin domain 1 (DDR1) that are implicated in cancer ...which IGF-I/IGF-IR signaling triggers a ...
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Alterations in IGF-I affect elderly: role of physical activity
... factor I (IGF-I) have an anabolic effect in adults, including the ...Serum IGF-I levels as well as GH secretion decline with advancing age [26, 92, ...
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Insulin like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation A potential autocrine growth factor
... factor I (IGF-I) mRNA by some tumor cell lines of neuroectodermal origin has been ...of IGF-I mRNA expression in these tumors, a more extensive analysis was ...expressed ...
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Regulation by fasting of rat insulin like growth factor I and its receptor Effects on gene expression and binding
... factor I (IGF-I) mRNA levels, on levels of different IGF-I mRNAs generated by alternative splicing of the primary IGF-I transcript, and on IGF-I receptor ...
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Little effects of Insulin-like Growth Factor-I on testicular atrophy induced by hypoxia
... of IGF-I are reduced [1] because liver biosynthesis and GH receptor expression in hepatocytes are ...that IGF-I supplementation recovers testicular atrophy associated to experimental cir- ...
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Assessment of Growth and Its Regulation through Insulin-like Growth Factor-I in Southern flounder, Paralichthys lethostigma
... cloned IGF-I cDNA in southern flounder and investigated whether alterations in circulating IGF-I and hepatic IGF-I mRNA might accompany changes in growth under different ...
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Insulin like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans
... factor I (IGF-I) on fuel oxidation and insulin sensitivity, eight healthy subjects were treated with saline and recombinant human (IGF-I (10 ...day. IGF-I treatment led to ...
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A low dose euglycemic infusion of recombinant human insulin like growth factor I rapidly suppresses fasting enhanced pulsatile growth hormone secretion in humans
... deconvolution algorithm, decreased with a t 1/2 of 16.6 min and remained suppressed thereafter. Suppression of GH secretion rates occurred within 60 min when total and free IGF-I concentrations were ...
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Central and peripheral actions of somatostatin on the growth hormone–IGF I axis
... and IGF-I suppression, which suggests a more complex mechanism than attributable to inhibition of GH release ...that IGF-I mRNA and protein levels were suppressed in a dose-dependent manner by ...
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A unique receptor independent mechanism by which insulinlike growth factor I regulates the availability of insulinlike growth factor binding proteins in normal and transformed human fibroblasts
... peptides. IGF-I has been shown to increase IGFBP concentrations in vivo and in vitro, but the mechanism and significance of this action are ...with IGF-I markedly stimulated the appearance of ...
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PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms
... The regulatory impact of PI3K could be vali- dated by preclinical studies with PI3K inhibitors. LY294002, a quercetin analogue and PI3K inhibitor, decreased cell proliferation in non-gastrointestinal neuroendocrine cell ...
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Original Article Influence of polymorphisms in insulin-like growth factor-1 on the risk of osteoporosis in a Chinese postmenopausal female population
... We conducted interaction analysis between the rs35767 polymorphism and demographics and BMD on the risk of osteoporosis (Table 3). Our study found that CT+TT genotype of rs35767 was significantly associated with mod- ...
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Original Article The role of EphB4 and IGF-IR expression in breast cancer cells
... that IGF-IR might be the upstream gene of EphB4, when com- bined with IGF-I can induce higher expression of EphB4 through PI3K-Akt/ PKB signaling ...of IGF-IR, EphB4 and signaling pathway in ...
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Modulation of IGF-I Receptor Activation by the IGF-I peptides
... the IGF-I growth factor, and its function remains ...on IGF-I receptor activation in skeletal muscle ...tested IGF- IR activation by immunoblotting for Phospho-Protein Kinase B (P-AKT) ...
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