IDH1 mutation
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
... frequent IDH1 mutation, R132H, can be effectively targeted in a ...R132H mutation was expressed in sarcoma cells obtained by exposure to 3-methylcholantrene that were injected subcutaneously in the ...
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IDH1 Mutation in Gliomas in Baghdad by Immunohistochemical Study
... Abstract: IDH1 (isocitrate dehydrogenase 1) mutation might be encounter in the low-grade glioma occurs in early stages of development and directs the progression of the tumor to a higher ...of IDH1 ...
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IDH1 mutation detection by droplet digital PCR in glioma
... that IDH1 mutation correlated with both the specific mutation profiles and distinctive clinical behaviors better than traditional histology-based ...IDH mutation, mutations in the TERT ...
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Patterns of Tumor Contrast Enhancement Predict the Prognosis of Anaplastic Gliomas with IDH1 Mutation
... by IDH1 mutation may consequently have different genetic characteristics compared with tumors unaccompanied by the mutation, which may lead to their varied biologic ...the IDH1 ...
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MR Elastography Analysis of Glioma Stiffness and IDH1 Mutation Status
... as IDH1 mutation using intrinsic biomechanical infor- mation and MRE-derived shear stiffness—possibly being used as a biomarker to both identify and spatially resolve genetically induced alterations of ...
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Isocitrate dehydrogenase 1 (IDH1) mutation-specific microRNA signature predicts favorable prognosis in glioblastoma patients with IDH1 wild type
... the IDH1 mutation was ...23 IDH1 mutation-specific miRNAs were classified as risky group and protective group miRNAs based on the significance analysis of microarrays d-score (SAM d-value) ...
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MR Imaging–Based Analysis of Glioblastoma Multiforme: Estimation of IDH1 Mutation Status
... BACKGROUND AND PURPOSE: Glioblastoma multiforme is highly aggressive and the most common type of primary malignant brain tumor in adults. Imaging biomarkers may provide prognostic information for patients with this ...
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Original Article Surgically treated incidentally discovered low-grade gliomas are mostly IDH mutated and 1p19q co-deleted with favorable prognosis
... harbored IDH1 mutation and 1p/19q co- deletion. IDH1 mutation and 1p/19q deletion were suggested as favorable markers for sensi- tivity to adjuvant genotoxic treatment (radiation therapy and ...
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Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma
... in Idh1-KI chondrocytes. IDH1-R132Q was identified in a patient’s chondrosarcoma tumor ...expressing IDH1- R132Q in chondrocytes by crossing a mouse expressing a conditional Idh1-R132Q knockin ...
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Genetic and clinical characteristics of primary and secondary glioblastoma is associated with differential molecular subtype distribution
... that IDH1 mutation might characterize the Proneural subtype, however this cannot be considered as a definitive marker for sGBM ...an IDH1 mutation in pGBM exhibited approximately three times ...
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<p>Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients</p>
... that IDH1 mutation in gliomas is associated with lower levels of chronic in fl ammation which could account for the improved prognosis in this group of ...IDH mutation-driven inhibition of HIF1 and ...
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Can Diffusion Tensor Imaging Noninvasively Detect IDH1 Gene Mutations in Astrogliomas? A Retrospective Study of 112 Cases
... with IDH1 mutation and 11, 11, and 43 cases without mutation in grades II, III, and IV, respectively) were retrospectively ...without IDH1 R132H mutation were compared by means of ...
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<p>The impact of adjuvant radiotherapy on molecular prognostic markers in gliomas</p>
... of IDH1 (one case) and IDH2 mutations (one case) over the course of the ...an IDH1 mutation and extensive MGMT methylation, which recurred 12 months after first surgery with transformation to ...
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IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing
... with IDH1 mutation belonged to “clear cell group” without ...was IDH1 mutant was unexpected since all the three TCGA HCCs with IDH1 mutation had a pseudoglandu- lar ...with IDH1 ...
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Relationship between Tumor Enhancement, Edema, IDH1 Mutational Status, MGMT Promoter Methylation, and Survival in Glioblastoma
... tween gene expression and radiographic images, including physiologic imaging techniques such as perfusion and diffu- sion MR imaging, showing that regions of tumor with high blood volume and/or low apparent diffusion ...
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Combination genetic signature stratifies lower-grade gliomas better than histological grade
... (IDH1) mutation and chromosome 1p/19q codeletion represent the most important molecular markers with clinical implications in lower-grade ...Promoter mutation of telomerase reverse transcriptase ...
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Oncometabolic mutation IDH1 R132H confers a metformin- hypersensitive phenotype
... gene mutation on energy production in a target cell ...knock-in IDH1 mutation with regard to the different carbon sources that can be oxidized by cell mitochondria to produce ...of ...
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Case Report IDH1 R132H mutation in a pilocytic astrocytoma: a case report
... nohistochemical IDH1 R132H mutation was confirmed by molecular analysis and the histo- pathological diagnosis was ...hotspot IDH1 muta- tion in a pilocytic astrocytoma suggest that genes involved in ...
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A Case Report of Concurrent IDH1 and NPM1 Mutations in a Novel t(X;2)(q28;p22) Translocation in Acute Myeloid Leukaemia without Maturation (AML-M1)
... NPM1 mutation during clonal evolution ...IDH1 mutation. Despite the favourable prognosis of the NPM1 with IDH1 mutations in AML, the patient passed away on day 9 ...
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PubMedCentral-PMC5380481.pdf
... IDH mutation in glioma has been widely accepted, little is known about the unique molecular features that defines the chemo- sensitivity in IDH1 mutant ...introducing IDH1 mutation in a glioma ...
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