IFN- α
Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α
... or IFN-α in a multinational, multicenter, randomized, open-label, parallel-group, phase 2/3 study in patients with confirmed metastatic or inoperable locally advanced RCC eligible for standard therapy with ...
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The antitumor effects of IFN α are abrogated in a STAT1 deficient mouse
... of IFN-α ...an IFN-γ–dependent tumor surveillance system in immunocompetent ...of IFN-γ on chemically induced fibrosarcomas were mediated primarily through a direct effect on the tumor ...of ...
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The antihypertension drug doxazosin suppresses JAK/STATs phosphorylation and enhances the effects of IFN-α/γ-induced apoptosis
... cells. IFN-α is also a key indicator for viral infections through Toll-like receptors (TLRs), where macrophages and natural killer (NK) cells are induced, which enhances antigen presentation to lymphocytes ...
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IFN λ1 with Th17 axis cytokines and IFN α define different subsets in systemic lupus erythematosus (SLE)
... both IFN types. Therefore, an impact of IFN-λ subtypes should be considered in the context of a positive IFN signature in SLE [7, 17, 43, ...of IFN-λ and IFN-α subtypes could ...
12
Enhanced IFN α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus
... interferon- α (IFN- α ) production by plasmacytoid dendritic cells (pDCs) increased and was positively correlated with disease activity in systemic lupus erythematosus ...producing IFN- ...
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Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-α/Fc fusion proteins expressed in Pichia pastoris
... conventional IFN-α with affordable ...alternative IFN-α with an excel- lent pharmacokinetic performance and at a low cost for developing ...active IFN-α/Fc fusion proteins were ...
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Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth
... of IFN-α and IFN-λ prompted us to compare the effects of local, at the tumor site, ...the IFN-α/λ combination to tumor bearing mice after partial tumor ...the IFN combination, a ...
9
The anti HBV effect mediated by a novel recombinant eukaryotic expression vector for IFN α
... date, IFN-α is widely used in clinical therapy for pa- tients with chronic hepatitis B ...of IFN-α, such as short half-life, serious side effects and instable plasma drug concentration ...
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Pegylated IFN α regulates hepatic gene expression through transient Jak/STAT activation
... of IFN-α has been acquired through cell culture exper- iments and mouse models with genetic deletions of IFNs, IFN receptors, or components of the Jak/STAT pathway ...the IFN-α–induced ...
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Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN α–stimulated STAT2 independent production of IFN γ in the brain
... I IFN respons- es and are highly susceptible to viral ...of IFN-α are markedly exacerbated (13), point to alternative, but as-yet unidentified, signaling pathways that can medi- ate both ...
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The synergistic effect of IFN α and IFN γ against HSV 2 replication in Vero cells is not interfered by the plant antiviral 1 cinnamoyl 3, 11 dihydroxymeliacarpin
... of IFN-α/β or IFN-γ to their specific cell receptors modified the transcriptional and translational environ- ments such that an antiviral state is induced ...to IFN-induced antiviral state ...
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Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7
... HaCaT-derived exosomes were characterized by AFM (Figure 2A) and for the expression of specific exosomal markers (Figure 2B) (18). These exosomes recapitulated the effects of SLE patient–derived exo- somes (Figure 2C). ...
13
IFN α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
... worldwide. IFN-α inhibits viral replication in vitro and in vivo, and pegylated IFN-α is a commonly administered treatment for individuals infected with ...typical IFN-stimulated ...
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Interferon α (IFN α) suppresses HTLV 1 gene expression and cell cycling, while IFN α combined with zidovudin induces p53 signaling and apoptosis in HTLV 1 infected cells
... that IFN-α has only a static ...and IFN-α were added (Figure ...and IFN-α, while IFN-α alone exhibited mar- ginal effects (Figure 6A, ...exogenous ...
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Toll like receptors and IFN α: partners in autoimmunity
... Many autoimmune diseases are thought to be precipitated by viral infec- tions. In this issue of the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections not only trigger expansion ...
5
Alpha/Beta Interferon (IFN-α/β)-Independent Induction of IFN-λ1 (Interleukin-29) in Response to Hantaan Virus Infection
... inhibit IFN-  induction. The observation that HTNV induced IFN- 1 in the absence of the ...induces IFN- 1 and MxA in the complete absence of type I ...produce IFN- 1 and then used to ...
9
Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent Responses
... to IFN- ␣ /  . This is clearly demonstrated by elevated and sustained Ifn ␣ /  as well as select ISG expression despite IFNAR deletion on ...induce IFN-  following TMEV and La Crosse virus ...
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Mechanism of HCV's resistance to IFN α in cell culture involves expression of functional IFN α receptor 1
... to IFN-a treatment in chronic hepatitis C ...of IFN-a and b receptor in the liver of patients with a hepatitis C virus related chronic liver disease between patients with IFN responders and ...the ...
18
Inhibition of Alpha Interferon (IFN-α)-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN-α
... by IFN- ␣ be- cause this is the only human hepatoma cell line with constitutive expression of ...to IFN-␣ in Huh-7 cells by real-time ...of IFN-␣ 4 h after treatment. Treatment with 1,000 U/ml of ...
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Systemic Interferon-α (IFN-α) Treatment Leads to Stat3 Inactivation in Melanoma Precursor Lesions
... from sections of an atypical nevus (a-c) and normal skin surrounding the nevus (d-f), obtained from a patient before IFN-a treatment, were incubated with a Statl (a and d), Stat2 (b and [r] ...
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