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IFN-γ receptor 1

In a novel form of IFN γ receptor 1 deficiency, cell surface receptors fail to bind IFN γ

In a novel form of IFN γ receptor 1 deficiency, cell surface receptors fail to bind IFN γ

... Patients. Four patients from three unrelated families were investigated. Clinical features will be reported elsewhere. Briefly, all presented with disseminated BCG infection shortly after inoculation with live BCG ...

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Role of CCR5 in IFN γ–induced and 
cigarette smoke–induced emphysema

Role of CCR5 in IFN γ–induced and cigarette smoke–induced emphysema

... its receptor can cause strik- ing alterations in tissue ...although IFN-g is a potent stimulator of a wide variety of CC and CXC chemokines, the selective neutralization and/or ablation of CCR5 caused an ...

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Gamma Interferon (IFN-γ) Receptor Restricts Systemic Dengue Virus Replication and Prevents Paralysis in IFN-α/β Receptor-Deficient Mice

Gamma Interferon (IFN-γ) Receptor Restricts Systemic Dengue Virus Replication and Prevents Paralysis in IFN-α/β Receptor-Deficient Mice

... 4 IFN- ␥ R-dependent signaling reduces systemic levels of DENV by day 4 after ...qRT-PCR 1, 2, 4, and 6 days after infection (5 ⫻ 10 8 GE of strain S221 ...

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Psychological stress suppresses innate IFN gamma production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide

Psychological stress suppresses innate IFN gamma production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide

... innate IFN- γγγγ response in vivo: In the present study we demonstrate that restraint stress suppresses innate IFN-γ production induced following an in vivo challenge with bacterial ...increased ...

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Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages

Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages

... IRF- 1-dependent genes contribute to in IFN- ␥ -activated macro- phages, we analyzed groups A to D (Table 2) separately by gene set overlap analysis using ...by IFN-␥ in a manner de- pendent on ...

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IL 1 Receptor Type II Production Is Upregulated by IL 4 and IL 13, and Downregulated by IFN γ in Mouse Gingival Epithelial Cells

IL 1 Receptor Type II Production Is Upregulated by IL 4 and IL 13, and Downregulated by IFN γ in Mouse Gingival Epithelial Cells

... by IFN-γ, and also reported with human monocytes [42]. IFN-γ is the signature cytokine of Th1-type responses and considered to be the main phagocyte-activating cytokine, while it is also ...

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Interferon-γ acts as a regulator in the trade-off between phagocytosis and production performance in dwarf chickens

Interferon-γ acts as a regulator in the trade-off between phagocytosis and production performance in dwarf chickens

... Interferon- γ (IFN- γ ) is critical for innate and adaptive immunity against viral and bacterial ...infections. IFN- γ reportedly affects the phagocytic ability of monocytes and ...

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Gamma Interferon (IFN-γ) Receptor Null-Mutant Mice Are More Susceptible to Herpes Simplex Virus Type 1 Infection than IFN-γ Ligand Null-Mutant Mice

Gamma Interferon (IFN-γ) Receptor Null-Mutant Mice Are More Susceptible to Herpes Simplex Virus Type 1 Infection than IFN-γ Ligand Null-Mutant Mice

... the IFN-g knockout strains (GKO and RGKO mice) and 129/Sv//Ev would not be ex- pected to influence the results reported ...both IFN-g mutant and control mice, with males being more susceptible than females ...

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Influenza Virus Vaccination Induces Interleukin-12/23 Receptor β1 (IL-12/23Rβ1)-Independent Production of Gamma Interferon (IFN-γ) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23Rβ1 or IFN-γ Receptor I

Influenza Virus Vaccination Induces Interleukin-12/23 Receptor β1 (IL-12/23Rβ1)-Independent Production of Gamma Interferon (IFN-γ) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23Rβ1 or IFN-γ Receptor I

... IL-12/23 receptor1 (IL-12/23R ␤ 1) deficiencies, two patients with partial IFN- ␥ receptor I (pIFN- ␥ RI) deficiencies, and five healthy ...proliferation, IFN- ␥ production, ...

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A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations

A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations

... (IFN-α, IFN-β, and IFN-ω), type II (IFN-γ), and type III (IFN-λ1, IFN-λ2, and IFN-λ3) ...Each IFN family has its specific receptor (IFNAR, IFN- ...

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Molecular Characterization, 3D Modeling of Grass Carp Interleukin 10 Receptor 1 (IL10R1)

Molecular Characterization, 3D Modeling of Grass Carp Interleukin 10 Receptor 1 (IL10R1)

... Interleukin-10 (IL-10) was first described as an activity production by mouse Th2 cells that inhibited activation and cytokine production by Th1 cells [1]. Since its dis- covery, the biological effects of IL-10 ...

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Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis

Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis

... on IFN-γ signaling [18]. IFN-γ was recently reported to promote spontaneous papilloma and cutaneous malignant melanoma ...Importantly, IFN-γ can induce the production of ...

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Immune Responses of CD4 + T-Cells of MDR-TB Patients to M.Tuberculosis Total Lipid Antigens

Immune Responses of CD4 + T-Cells of MDR-TB Patients to M.Tuberculosis Total Lipid Antigens

... that, IFN-γ concentration mean in MDR-TB and TB patients was significantly lower than that of PPD-positive healthy donors ...addition, IFN-γ levels in PPD-negative donors were lower than those ...

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IFN γ–related mRNA profile predicts clinical response to PD 1 blockade

IFN γ–related mRNA profile predicts clinical response to PD 1 blockade

... of IFN-γ– and T cell–associated inflammatory genes can predict responsive- ness to PD-1 blockade across different tumor types, we undertook a signature selection exercise with a larger and more ...

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Cerebral vessel laminins and IFN γ define Trypanosoma brucei brucei penetration of the blood brain barrier

Cerebral vessel laminins and IFN γ define Trypanosoma brucei brucei penetration of the blood brain barrier

... with 1% bovine serum albumin and ...for 1 hour at room ...AnTat 1:1E stabilate (1:5,000) and goat polyclonal anti–GLUT-1 (1:40; Santa Cruz Biotechnology) antisera for 24–48 hours ...

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Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis

Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis

... (Th) 1-mediated inflammatory disease with unknown aetiology, characterized by the for- mation of noncaseating granulomas, and involving accu- mulations of macrophages and T cells, primarily affecting the lungs ...

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Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma

... To determine the effect of constitutive- versus immuno- proteasome processing on antigen presenta- tion by melanoma cells, we selected HLA-Cw3 + , NY- ESO-1 expressing cell lines and induced IP expression in each ...

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Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

... 10 and IL-4 [15]. Arginase, however, is not induced. A "deactivation" state of macrophages that is similar to Type II macrophages has also been described by Gordon [6]. Alzheimer's disease (AD) is characterized ...

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Individual T helper cells have a quantitative cytokine memory

Individual T helper cells have a quantitative cytokine memory

... of IFN-γ production was a stable feature of individual Th1 cells that was memorized for at least one month in vivo, even upon immunological ...produced IFN- amount defined a cell’s capacity to ...

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T cell–mediated vascular dysfunction of human allografts results from IFN γ dysregulation of NO synthase

T cell–mediated vascular dysfunction of human allografts results from IFN γ dysregulation of NO synthase

... Neutralizing IFN-g completely prevented both vascular dysfunction and changes in NOS expression; neutralizing TNF reduced IFN-g production and partially prevented ...including IFN-g and TNF. We ...

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