IFN Regulatory Factor-1
Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages
... of IFN-␥-regulated ...of IFN- ␥ -regulated genes that depend on STAT-1 and IRF-1 but not on IRF-3, IRF-7, or CIITA for their ...STAT- 1 ⫺/⫺ , CIITA ⫺/⫺ , and IRF3⫻7 ⫺/⫺ macrophages ...
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In vivo alterations of IFN regulatory factor 1 and PIAS1 protein levels in cystic fibrosis epithelium
... of IFN-γ of 10, 25, and 100 units/mL, though the reported concentration of IFN-γ in airway epithelial lining fluid is estimated to be less than 2 units/mL ...er IFN-γ ...Higher IFN-γ ...
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Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice
... of IFN-inducible genes have been identified to date; most of these are activated by the JAK-STAT signal transduc- tion cascade (6, 7, 14, 25, ...the IFN regulatory factor 1 ...
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A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response
... We next wanted to investigate whether R6 interacts with other cellular proteins that associate with pIRF3 in the nucleus. Upon its phosphorylation and dimerization, pIRF3 translocates to the nu- cleus, where it ...
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A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection
... I IFN induction in the antiviral effects of the miR-34 family and confirmed that these miRNAs potentiate interferon regulatory factor 3 (IRF3) phosphorylation and translocation to the nucleus, the in- ...
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Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice
... Figure 1 and 1 show that induction of EAE leads to increased IRF7 gene ...I IFN and its response elements, as well as with previous stu- dies [7,8,16], we found expression of IRF7 mRNA by Th1 and ...
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Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP
... abrogates IFN-  production by inhibiting NF- B and blocking IRF-3 from recruiting its coactivator, CBP, which may be important for the early events leading to HSV-1 ...
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HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection
... kinase 1 (TBK1) and inhibitor of kappa B kinase epsilon (IKK ...interferon regulatory factor 3 (IRF3) and IRF7 ...leads IFN induction via the adaptors TIR domain- containing adaptor-inducing ...
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NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3
... TBK1-interferon regulatory fac- tor 3 (IRF3) branch of the RIG-I signaling pathway but not with NF- B ...the IFN master regulator IRF7 nor any of the related transcription factors IRF2, IRF5, and IRF9 ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... the IFN system, interfer- ing either with IFN induction, IFN signaling, or the action of IFN-induced effector proteins (23, ...blocking IFN induction is a most efficient and widespread ...
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Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB
... gene factor 3 (ISGF3) nuclear translocation by inducing importin ␣ 5 degradation ... 1 and CRM1, showing a unique inhibitory strategy against nuclear transport of host proteins ...
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Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization
... Rubicon inhibits dimerization of IRF3 upon virus infection. Control and Rubicon knockdown RAW264.7 cells were infected with PR8-GFP, and cytoplasmic and nuclear fractions were obtained; phosphorylated IRF3 was then ...
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Apoptosis Induced by Mammalian Reovirus Is Beta Interferon (IFN) Independent and Enhanced by IFN Regulatory Factor 3- and NF-κB-Dependent Expression of Noxa
... Noxa expression is upregulated following reovirus infection in an IRF-3- and NF- B-dependent manner. In attempting to identify a candidate protein that is a transcriptional target of IRF-3 or NF- B that facilitates ...
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Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population
... that IFN regulatory factor 5 (IRF5) gene polymorphisms are significantly associated with systemic lupus erythematosus (SLE) in several white ...
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HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3
... To exclude the possibility that some subtle effects of Vpu on IRF-3 were missed because the cells were examined in bulk, we next performed fluorescence-activated cell sorting (FACS)-based assays. The pCG vectors used in ...
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IFN regulatory factor–8 expression in macrophages governs an antimetastatic program
... RNA-seq studies. The sequencing libraries were prepared with the TruSeq Stranded Total RNA kit (Illumi- na) from 1 μg total RNA. Following the manufacturer’s instructions, the first step depletes rRNA from total ...
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Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells
... 3; IFN: Interferon; IL1B: Interleukin 1 beta; IL6: Interleukin 6; IRF3: Interferon regulatory factor 3; ISRE: IFN-stimulated response elements; LPS: Gram-negative lipopolysaccharide; ...
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Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... specific IFN- stimulated genes that mediate diverse functions including cellular responses to inflammation, programmed cell death and tumor suppression [23, ...
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Dysfunctional interferon α production by peripheral plasmacytoid dendritic cells upon Toll like receptor 9 stimulation in patients with systemic lupus erythematosus
... of IFN-α signature genes, indicating that SLE PBMCs have already been exposed to IFN-α, which is mainly produced by pDCs (Figure ...file 1 [Supplementary Figure ...file 1 [Supple- mentary ...
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Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.
... These classes of inflammatory cells produce an assortment of cytokines, such as tumor necrosis factor alpha TNF-a, alpha interferon IFN-ot, gamma interferon IFN-y, interleukin-1 alpha IL[r] ...
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