IFN-regulatory factor 3
Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP
... (SeV)-induced IFN- production, and its transcrip- tional activation domain was not responsible for this inhibition ...necrosis factor alpha treatment and expression of NF- B-dependent genes through ...
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Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB
... (dsRNA)-induced IFN-  expression in a dose-dependent ...the IFN transcriptional fac- tors IFN regulatory factor 3 (IRF3) and NF- ...of IFN-  in NS5-expressing or ...
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Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization
... I IFN signaling, since Rubicon did not affect IFN-  luciferase activity mediated by molecules upstream of IRF3 ...I IFN gene expression upon virus infection, which undergoes phosphorylation, ...
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NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3
... of IFN-  in SFSV-infected cells is inhibited by NSs, although SFSV does not destroy any of the key antiviral host factors that other dipteran-borne phleboviruses ...prohibiting IFN-  promoter ...full ...
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Apoptosis Induced by Mammalian Reovirus Is Beta Interferon (IFN) Independent and Enhanced by IFN Regulatory Factor 3- and NF-κB-Dependent Expression of Noxa
... Mammalian orthoreoviruses (reoviruses) cause apoptosis- associated encephalitis and myocarditis in infected newborn mice (26, 55). As such, these viruses are useful model pathogens for studies of cell death signaling ...
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HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection
... of IFN regulatory factor 3 (IRF3), during murine norovirus (MNoV) infection in cultured den- dritic ...for IFN induction and IRF3 phosphorylation during MNoV in- ...for IFN ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... (IFN) regulatory factor 3 ...the 3⬘ polyadenylate tail, according to the published sequence for human IRF-3 (4) (GenBank accession ...transcription factor that responds to ...
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Melatonin: its possible role in the management of viral infections-a brief review
... development of severe diseases, such as bronchiolitis and pneumonia [37]. TNF-α is a prooxidant cytokine able to amplify the host inflammatory response to respiratory viral infections [38], stimulating the inducible NO ...
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RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression
... induces IFN regulatory factor 3 (IRF3) activation and IFN-1 gene expression with faster kinetics than does influenza A virus, without a requirement for viral protein synthesis or ...
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Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... the IFN-dependent pathway involves acti- vation of the IFN receptor by exogenous IFN- ␣ /  secreted from infected ...of IFN- ␣ or -  to its receptor triggers JAK/STAT signal transduction ...
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Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages
... transcription factor interferon regulatory factor 1 (IRF-1) is required for control of murine NV (MNV) replication and pathogenesis in ...by IFN- ␥ is independent of IFN- ␣ ...for ...
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A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response
... interferon regulatory factors (vIRFs), are critical modulators of the immune response and cell growth and also major players in disease pathogenesis ...the IFN response. In fact, it has been shown that ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... an IFN-  luciferase reporter (data not shown). In addition, two IRF-3 mutants (IRF-3 5D and IRF-3 ⌬ N60) were tested for the ability to transactivate the TRAIL pro- ...drogenase), ...
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HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3
... after activation of NF- B through cotransfection of a constitutively active mutant of IKK (IKK ca). Luciferase ac- tivities were determined 2 days posttransfection as described above. The results demonstrated that ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... the IFN-  gene represents the primary response to virus infection (13, 16, ...the IFN-  gene requires the consti- tutively expressed transcription factor interferon regulatory factor ...
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A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection
... I IFN induction in the antiviral effects of the miR-34 family and confirmed that these miRNAs potentiate interferon regulatory factor 3 (IRF3) phosphorylation and translocation to the nucleus, ...
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IFN regulatory factor–8 expression in macrophages governs an antimetastatic program
... Similar patterns were observed in the TCGA melanoma cohort. Patients with lower IRF8 expression showed worse overall survival, not only in patient tumors with a higher macrophage infiltration (P < 0.001), but also in ...
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Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein
... HeLa cells were infected with SeV and transfected with poly(I·C), and the distribution of native IRF3 was observed (Fig. 5). IRF3 accumulated in the nucleus of some uninfected cells [Fig. 5, (⫺)]. One reason that not all ...
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In vivo alterations of IFN regulatory factor 1 and PIAS1 protein levels in cystic fibrosis epithelium
... Cystic fibrosis (CF) is a disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) (1). CFTR is a protein kinase A–activated chloride channel responsible for the ...
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Rapid Upregulation of Interferon-Regulated and Chemokine mRNAs upon Injection of 108 International Units, but Not Lower Doses, of Adenoviral Vectors into the Brain
... individual IFN-regulated mRNA probes are indicated at the far ...of IFN-regulated mRNA expression using ImageJ ...each IFN-regulated mRNA by the OD value for the L32 control in each lane and was ...
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