IGF-1 and -2
IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway
... protein 2 (SFRP2) is a major paracrine mediator of BMSCs-AKT myocardial survival and reparative effects ...of IGF-1 in BMSCs resulted in increased cell sur- vival, immunomodulation, and functional ...
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IGF 1 induces SOCS 2 but not SOCS 1 and SOCS 3 transcription in juvenile Nile tilapia (Oreochromis niloticus)
... Genomic DNA was isolated from the liver tissue of Nile tilapia using the phenol/chloroform method. Based on the Nile tilapia genome database and a promoter-finding program (Neural Network Promoter Prediction, NNPP; ...
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Ontogenesis of somatomedin and insulin receptors in the human fetus
... factors 1 (IGF-1) and 2 (IGF-2), somatomedin A (SMA), multiplication-stimulating activity (MSA), and insulin was examined at the different ...and IGF-2 ...single ...
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Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?
... tissue, IGF-1 can influence PR ...observed IGF-1 and IGF-2-induced reduction of PR in EC cell lines, which was related to the activation of the PI3K/ Akt/mTOR pathway and ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... of IGF- 1R monoclonal ...both IGF-1 and IGF-2 to IGF-1R ...expressing IGF-1R ...to IGF-1R antibodies [94,95]. The class of IGF-1R monoclonal anti- bodies ...
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Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells
... to IGF-1 ...with IGF-1, MMP-9 and MMP-2 activity was increased and this enhanced activity was inhibited or abolished in the presence of wortmannin or PD98059 ...(Fig. 2). There ...
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Elevated insulin like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
... file 2: Figure ...and IGF- 1. For microarray analysis of gene expression, MCF7/IGF-1R cells were seeded at 60% confluence in 6-cm plates and subjected to three-day starvation in 5% ...
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Reproductive and metabolic endocrinology in rams selected for high or low plasma IGF 1 concentrations : a thesis presented in partial fulfilment of the requirements for the degree of Master of Animal Science at Massey University
... Cwikla, 1 994; Soderquist and Hulten, ...Cwikla, 1 994b). Scrotal circumference of rams in Experiment 1 was significantly larger in December than in March (see Figure 2 .... 1 ). On the ...
130
An “Abundance” Phenotype Hypothesis for Autism
... BDNF, IGF-1, IGF-2, IGFBP- 3, GHBP, leptin, testosterone, oxytocin) and some autism risk factors (such as maternal metabolic conditions, prenatal and postnatal nutritional supplements, infant ...
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Hypoglycemic effect of insulin like growth factor 1 in mice lacking insulin receptors
... administration, IGF-1 caused a prompt and sustained decrease of plasma glucose levels in IR-/- ...of IGF-1 were identical in normal mice (IR+/+) and in IR-/- ...with IGF-1 died ...
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Igf-i and zinc as a biomarker in early diagnosing cardiovascular complications in type 2 diabetics in the central india
... of IGF-1 in the circulation increased the risk for developing type 2 diabetes considerably during a ...circulating IGF-I levels have been associated with angiographically documented coronary ...
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Reproductive and metabolic endocrinology in rams selected for high or low plasma IGF 1 concentrations : a thesis presented in partial fulfilment of the requirements for the degree of Master of Animal Science at Massey University
... serum IGF-1 concentrations on plasma concentrations of testosterone and insulin and on reproductive performance in rams ...5 2 3 . 1 Introduction ...5 2 3 . 2 Materials and ...
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Original Article Insulin-like growth factor-1 protects ischemic myocardial cells via PI3K/AKT pathway
... CA), 1% Penicillin/Streptomycin (100 U/ml: ...and 1% GlutaMAX (Gibco, Carlsbad, CA), at 37°C under 5% CO 2 ...and 1% oxygen was produced by the Anaerobe Gas Generating Pouch System. ...
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OSTEOPOROSIS IN DIABETICS AND ITS RELATION TO IGF-1
... type 1 DM than type 2 but did not reach a significant ...type 1 DM subgroup showed lower BMD than type 2 DM subgroup ...type 1 DM subgroup when compared to controls and in type 1 ...
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Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance
... IRS-1. IGF-1 dependent activation of a cell causes enhanced IRS-2 signaling and increased IGF-I induced migration, adhesion and anchorage-independent ...to IGF-1 ...
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The matrix metalloproteinase and insulin-like growth factor system in oral cancer – a prospective clinical study
... There are numerous studies indicating an important role of MMP-2, MMP-3, MMP-13, IGF-1, and IGFBP-3 in dif- ferent malignancies. However, to the best of our knowledge, there is no report available on ...
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Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease
... total IGF-1 and IGFBP-3 (R&D Systems, Oxford, ...the IGF- 1 assay was ...the IGF-1 assay does not detect IGF-2, insulin, IGFBP-2, -3 or -4, and the ...
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An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
... that IGF-1R has an important role in inducing EMT, probably through activation of ...as IGF-1 and ...and IGF-1R for drug resistant patients that undergo ...
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Regulation of experimental autoimmune encephalomyelitis with insulin like growth factor (IGF 1) and IGF 1/IGF binding protein 3 complex (IGF 1/IGFBP3)
... included 1/20 of each cDNA sample, 5 m M of each primer, 200 m M dNTPs (Perkin-Elmer, Foster City, CA), and ...were 1 min at 94 8 C, 1 min at 55 8 C, and ...
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Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells
... to 1 and gene lists based on the up- and down- regulated genes over ...compound 2 was ...compound 2. To confirm effects of compound 2 on IGF-1 mediated signaling, similarity to a ...
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