IGF-1 and skeletal muscle
Regulation of muscle fibre phenotype, muscle mass and igf-1 gene expression in skeletal muscle in response to mechanical activity
... 6.5 IGF-1 and expression of muscle gene Although it has been estabhshed that muscle gene expression is activity dependent and high expression of IGF-1 mRNA in skeletal ...
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Muscle specific expression of IGF 1 blocks angiotensin II–induced skeletal muscle wasting
... and skeletal muscle ...increased muscle proteolysis and also decreases levels of circulating and skeletal muscle ...in skeletal muscle, leading to actin cleavage, an ...
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Evaluation of the role of paracrine/autocrine IGF-1 system in skeletal muscle adaptation
... Abstract Muscle is highly responsive to changes in functional demand, with overload and increased activity leading to hypertrophy, while decreased load, dennervation and joint immobilization can cause ...
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Betaine supplement enhances skeletal muscle differentiation in murine myoblasts via IGF 1 signaling activation
... of IGF-1 pathway in skeletal ...lean muscle mass and reduced the fat ...in muscle mass, but also in growth hormone, IGF-1 and insulin blood concentrations [49-51], ...
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Supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway and down regulates the E3 ligase MuRF1 in skeletal muscle of rats
... of muscle wasting and to an improvement of the whole body N-balance in rats suffering from can- cer ...plasma IGF-1 concentrations, no changes in body weights and muscle weights of the rats ...
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Postnatal Regulation of Bone Growth by Muscle IGF-1
... of IGF-‐1 effect on masseter muscle fiber size, due to high variability within the masseter muscle fibers mentioned ...and IGF-‐1 effects presented in this study again suggest ...
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Effects of IGF-1 isoforms on muscle growth and sarcopenia
... and muscle function, insulin‐like growth factor 1 (IGF‐1) plays a central role in muscle growth, differentiation, and regeneration (Scicchitano, Rizzuto, & Musarò, ...mammals, ...
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Insulin and IGF 1 receptors regulate FoxO mediated signaling in muscle proteostasis
... and IGF-1 are known to modulate a number of intracellu- lar pathways affecting protein metabolism, including mTOR and FoxO, but the relative roles of each hormone in muscle hypertrophy and atrophy ...
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Apoptosis and Skeletal Muscle in Aging
... of muscle tissue through multipli mechanisms induced by activation of IGF-1/Akt/mTOR, PGC-1 α , and/or other pathways including in- creased protein metabolism, redox balance, mitochondrial ...
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(IGF) Receptors in Skeletal Muscle: Measurement by
... showed total binding (['2'I]-IGF alone), three sections showed nonspecific binding ([ '2'I]-IGF and the homologous unlabeled IGF), and six to nine sections showed residual binding ([ 1[r] ...
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Interstitial IGF-I in exercising skeletal muscle in women
... bioavailable IGF-I in the muscle resulting from the increased IGF-I flux to the ...tissue-bound IGF-I stores. This view is supported by the net release of Ex-leg f-IGF-I at the end of ...
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Role of IGF-I in follistatin-induced skeletal muscle hypertrophy
... in skeletal muscle mass, requiring the type 1 IGF-I receptor/ Akt/mTOR ...of IGF-I and insulin, two ligands of the IGF-I receptor, in the follistatin hypertrophic action on ...
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Muscle specific inactivation of the IGF I receptor induces compensatory hyperplasia in skeletal muscle
... conclusion, IGF-I receptors are important for the establishment and maintenance of the mature muscle phenotype in normal and regenerating muscle ...the IGF-I receptor acts as an important ...
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Role of IGF/Insulin pathway in the skeletal muscle hypertrophy induced by follistatin
... in skeletal muscle mass requiring the type 1 IGF-I receptor/Akt/mTOR ...of IGF-I and insulin, two ligands of the IGF-I receptor, in the Follistatin hypertrophic action on ...
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Synergy Between Insulin-Like Growth Factor-I (igf-I) E-Peptides and Igf-I Signaling Alters Growth in Skeletal Muscle
... decrease IGF-IR ...enhanced IGF-I mediated receptor phosphorylation, in part through increasing the proportion of receptors on the cell ...the IGF-I dependent and independent effects of rodent ...
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Switching to fast growth: the insulin like growth factor (IGF) system in skeletal muscle of Atlantic salmon
... the IGF signalling pathway in ...of muscle growth in ...the IGF system including retained paralogues, and examine gene expression during the transition from a state of zero growth to fast ...
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Expression of the locally produced IGF-I splice variants in damaged-regenerating and stretched and stimulated skeletal muscle
... this: 1) something in the preparation of cDNA synthesis could have hampered the amplification in this highly sensitive amplification method, 2) there was a substantial kit-to-kit variation that generated different ...
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Function of mTOR complex 1 and 2 in skeletal muscle
... (J) Immunostaining with antibodies specific for P-PKB/AKTS473 using cross-sections of 60 day-old DmKO and control mice. (K) Schematic of the interactions contributing to the phenotype of RAmKO mice. Signaling pathway ...
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Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral feeding
... related muscle protein synthesis evaluated in the present ...liver IGF-I deficient and wild type mice regarding translational control of muscle protein ...liver IGF-I knockouts and wild type ...
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Mechanisms for Insulin-dependent Regulation of Skeletal Muscle Mitochondria by OPA-1
... and IGF-R from primary myoblasts and demonstrated that we were able to successfully ablate IR and IGF-R ( Figure 9A – Figure ...and IGF-R primary myoblasts that either received insulin stimulation ...
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