IGF-I and II
IGF I, IGF II and insulin promote differentiation of spermatogonia to primary spermatocytes in organ culture of newt testes
... IGF-I, IGF-II or ...of IGF-I (100 ng/ml) spermatogonia differentiated into primary spermatocytes in the pachytene stage ...2). IGF-II (100 ng/ml; ...of ...
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Genetic and environmental components of interindividual variation in circulating levels of IGF I, IGF II, IGFBP 1, and IGFBP 3
... factors I and II (IGF-I and IGF-II), and their binding proteins IG- FBP-1 and IGFBP-3 by measuring their serum concentra- tions in 32 monozygotic and 47 dizygotic adult twin ...
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A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells
... of IGF-I and/or IGF-II are observed in tumors such as neuroblastoma, Ewing sarcoma, and osteosarcoma ...Like IGF-I, IGF-II may be secreted by stromal cells ...both ...
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The effects of insulin and the insulin-like growth factors (IGF-I and IGF-II) on the proliferation and differentiation of cells isolated from placentae of non-diabetic and diabetic subjects
... The effects of insulin, IGF-I and IGF-II on growth rates were examined and compared in cultures of cells isolated from placental tissue obtained from 'normal' (n=30) and diabetic (n=22[r] ...
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The Insulin-like Growth Factor Binding Protein Superfamily: New Perspectives
... bind IGF-I and -II with particularly high-affinity results, presumably, from the interaction of the N-terminal and the C- terminal domains; the conserved C-terminal domain is unique to the ...
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NUTRITIONAL REGULATION OF IGF-I AND IGF BINDING PROTEINS.pdf
... of IGF-I and insulin allows for some overlap in their receptor specificity ...bind IGF receptors with approximately 1% the affinity of ...as IGF-I, even at concentrations that appear to ...
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The effects of infusion of insulinlike growth factor (IGF) I, IGF II, and insulin on glucose and protein metabolism in fasted lambs
... glucose production. Net protein loss was reduced after infusion of low and high dose rhIGF-I and insulin by 11% (P less than 0.05), 15% (P less than 0.01), and 12% (P less than 0.05), respectively. rhIGF-II ...
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Regulation of insulin like growth factor (IGF) I receptor expression during muscle cell differentiation Potential autocrine role of IGF II
... the IGF-I receptor and the expression of IGF peptides during differentiation of the mouse BC3H-1 muscle cell ...in IGF-I receptor sites determined by Scatchard ...in IGF-I ...
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Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia
... (IGF) I and II were determined by a modified IGF I and a new IGF II radioimmunoassay in normal children and adults, and in patients with acromegaly, isolated growth ...
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In vivo localization of the insulin like growth factors I and II (IGF I and IGF II) gene expression during human lung development
... Int J De,' Bioi 39 529 537 (1995) 529 Original Article In vivo localization of the insulin like growth factors I and II (lGF I and IGF II) gene expression during human lung development AU DE V lAllEMA[.] ...
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Human fetal and adult chondrocytes Effect of insulinlike growth factors I and II, insulin, and growth hormone on clonal growth
... by IGF I and ...that IGF II is a more potent stimulant of clonal growth of chondrocytes during fetal life, whereas IGF I ...
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Effects of insulin like growth factors on early embryonic chick limb myogenesis
... to IGF-I and–II were both blocked by PPP, an IGF1R inhibitor, and U0126, which blocks MEK activity and so prevents ERK ...blocked IGF-I induced MyoD expression and IGF-II ...
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Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells
... The IGF system (IGF-I, IGF-II, IGF-binding protein, and IGF-IR) performs an important role in the growth of various cancer cells, including colon cancer cells ...secreted ...
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Receptors and growth promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta
... factor I (IGF-I) and multiplication-stimulating activity (MSA, an IGF-II) on endothelial cells and pericytes from calf retinal capillaries and on endothelial and smooth muscle cells ...
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Signal transduction mechanism for glucagon-induced leptin gene expression in goldfish liver
... To further confirm whether the regulation of leptin expression was directly affected by glucagon, glucagon was routinely added to goldfish primary hepatocytes for static incubation. Similarly, in in vitro primary cell ...
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Protein variation and involvement of insulin-like growth factor during embryonic development in the olive flounder Paralichthys olivaceus
... The IGF-IGF receptor-IGF-binding protein system is a com- plex regulatory system that is essential for normal growth and development (Duan, 1997), and autocrine/ paracrine IGF-I is the ...
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Hepatoprotection and neuroprotection induced by low doses of IGF II in aging rats
... of IGF-II may be due to decreased peroxidative cell ...by IGF- II against free radical damage, we investigated the effect of IGF-II therapy on antioxidant enzymes and mito- ...
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Insulin like growth factor I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro
... 125I-labeled IGF-I demonstrated two high affinity specific binding sites (Kd ...of IGF-I, IGF-II, or insulin resulted in marked proliferation of human SCLC cells as evaluated ...
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Autonomous growth of a human neuroblastoma cell line is mediated by insulin like growth factor II
... factor II (IGF-II) mRNA was increased in two of eight neuroblastomas and in eight of eight pheochromocytomas, tumors of the adrenal medulla that occur in childhood and adulthood, ...type I ...
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Effect of maternal undernutrition during late pregnancy on hormonal status and metabolic changes in neonatal lambs
... and IGF-II in each group were at similar levels, but the secretions of T 4 , INS, and IGF-I in RG1 and RG2 were suppressed by maternal undernutrition during late ...of IGF-I se- ...
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