IGFBP-5
IGFBP-5 enhances epithelial cell adhesion and protects epithelial cells from TGFβ1-induced mesenchymal invasion
... surprise, IGFBP-5, despite having initially induced adhesion to the substra- tum, also induced the formation of ...whereas IGFBP-5 increased spheroid num- bers ...and IGFBP-5 (in ...
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Regulation of the IGFBP 5 and MMP 13 genes by the microRNAs miR 140 and miR 27a in human osteoarthritic chondrocytes
... joint, IGFBP-5 plays an important storage role for IGF-1 ...increasing IGFBP-5 concentration led to an increased level of IGF-1 and was associated with a reduction in cartilage destruction ...
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Relative roles of TGF-β and IGFBP-5 in idiopathic pulmonary fibrosis
... the IGFBP-5-induced cell to extracellular matrix adhesion in MCF-7 ...of IGFBP-5 with α 2 and β 1 integrins leading to the activation of ILK and Akt and improved epithelial cell adhesion and ...
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Expressions of IGFBP-5, cFLIP in cervical intraepithelial neoplasia, cervical carcinoma and their clinical significances: a molecular pathology
... IGFBP down-regulation in CC remains unclear, though it may be explained by the down-regulation of HPV encoded proteins or the transcription of IGFBP-5 mRNA. Irmler et al. [7] were the first group to ...
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IGFBP-5 enhances epithelial cell adhesion and protects epithelial cells from TGFβ1-induced mesenchymal invasion
... surprise, IGFBP-5, despite having initially induced adhesion to the substratum, also induced the formation of ...whereas IGFBP-5 increased spheroid numbers (Figure ...and IGFBP-5 ...
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Transcriptional regulation of the IGF signaling pathway by amino acids and insulin like growth factors during myogenesis in Atlantic salmon
... both IGFBP-5 paralogues ...induced IGFBP-5 expression in smooth muscle cells [76] and could converge with the amino acid signaling pathway on mTORC1, where recently, phosphorylation of S1261 ...
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IGFBP-4 and −5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells
... of IGFBP-4 and −5 in the first trimester was the maternal decidua, since IGFBP-5 had only been observed in villi in the second and third trimester ...recently, IGFBP-4 immunoreactivity ...
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Evolution of ancient functions in the vertebrate insulin like growth factor system uncovered by study of duplicated salmonid fish genomes
... Unfortunately, IGFBP-6 models were necessarily excluded from further analysis owing to poor inferred local model qual- ity in the critical NBP thumb region (fully discussed in the Materials and ...key ...
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Fisch, Thomas Martin (2005): Effects of insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression on adrenal and renal growth processes and functions: findings in transgenic mouse models. Dissertation, LMU München: Tierärztliche Fakultät
... IGFBPs 5 . Transgenic mice, overexpressing IGFBP-1 exhibit several organ-related alterations, with the brain and kidney being most affected (see under ...homeostasis. IGFBP-2 transgenic mice are ...
172
IGFBP-2 and -3 co-ordinately regulate IGF1 induced matrix mineralisation of differentiating human dental pulp cells
... was IGFBP-4 N IGFBP-5 N IGFBP-6 N IGFBP-2 N IGFBP-3 N IGFBP-1 – ...1). IGFBP-4, -5 and -6 expression did not alter during differentiation of ...that ...
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Protease resistant form of insulin like growth factor binding protein 5 is an inhibitor of insulin like growth factor I actions on porcine smooth muscle cells in culture
... the IGFBP-5 protease and if direct infusion of pro- tease-resistant forms of IGFBP-5 into lesions results in attenu- ation of IGF-I ...that IGFBP-5–specific serine protease ...
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Expression of the locally produced IGF-I splice variants in damaged-regenerating and stretched and stimulated skeletal muscle
... of IGFBP-4 and IGFBP-5 is acutely regulated during adaptive changes induced in skeletal muscle by damage via a myotoxic ...that IGFBP-4 and IGFBP-5 were expressed at a ...
260
Altered placental expression of PAPPA2 does not affect birth weight in mice
... Placentae and embryos were homogenized at room tem- perature in 600 μL of buffer RLT (Qiagen, Ontario, Can- ada) using pestles. The samples were further homogenized using Qiashredders (Qiagen, Ontario, Can- ada) and ...
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Meissner, Joseph A. (2006): Histologische und immunhistochemische Untersuchungen zur Involution der Milchdrüse des Rindes (Bos taurus). Dissertation, LMU München: Tierärztliche Fakultät
... Insulin-like growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell death and plasminogen activation in the mammary gland Proc Int Con Biol Mamm Gland S3.4, 18[r] ...
145
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells
... 1; IGFBP-3: Insulin-like growth factor-binding protein 3; IGFBP-5: Insulin-like growth factor-binding protein 5; IGFBP-6: Insulin-like growth factor-binding protein 6; IL- 1 α : ...
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Serum IGF-1, IGFBP-3 and their ratio: Potential biochemical growth maturity indicators
... and IGFBP-3 by using red plain blood collection vials ...and IGFBP-3 Enzyme-Linked Immunosorbent Assay kits (ELISA, Diagnostic System Laboratories, TX, USA), spe- cific for IGF-1 and IGFBP-3 ...
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The Histone H3K9 Demethylase Kdm3b Is Required for Somatic Growth and Female Reproductive Function
... To explore the pathophysiological causes for the impaired reproductive function of the female Kdm3bKO mice, we examined their sexual matura- tion by checking vaginal opening time and their es- trous cycles, which are ...
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Molecular Mechanisms Linking Amino Acid (Leucine) Deprivation to IGFBP-1 Hyperphosphorylation in Fetal Growth Restriction
... induce IGFBP-1 phosphorylation prompted the investigation of the ...of IGFBP-1 phosphorylation under leucine ...GCN2 5 , the exclusive nutrient sensor to the AAR 4 ...
206
Common genetic variation in IGF1, IGFBP 1, and IGFBP 3 in relation to mammographic density: a cross sectional study
... The variant allele of rs1520220 in IGF1 was inversely associ- ated with mammographic density in the current study. In con- trast, the variant allele has been positively associated with circulating levels of IGF1 in ...
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Investigation of insulin like growth factors/insulin like growth factor binding proteins regulation in metabolic syndrome patients
... of IGFBP-2, IGFBP-1, IGFBP-3, IGF-1, and IGF-2 in diabetic patients who were assigned to two groups: MSx diabetic and non-MSx diabetic ...of IGFBP-2 compared with healthy ...between ...
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