IκB kinase
Inhibitor of IκB kinase activity, BAY 11 7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells
... Introduction: Plasmacytoid dendritic cells (pDCs) play not only a central role in the antiviral immune response in innate host defense, but also a pathogenic role in the development of the autoimmune process by their ...
13
Local treatment with the selective IκB kinase β inhibitor NEMO binding domain peptide ameliorates synovial inflammation
... Nuclear factor (NF)-κB is a key regulator of synovial inflammation. We investigated the effect of local NF-κB inhibition in rat adjuvant arthritis (AA), using the specific IκB kinase (IKK)-β blocking NF-κB ...
9
Dengue Virus Subverts the Interferon Induction Pathway via NS2B/3 Protease-IκB Kinase ε Interaction
... Dengue is the world’s most common mosquito-borne viral infection and a leading cause of morbidity throughout the tropics and subtropics. Viruses are known to evade the establishment of an antiviral state by regulating ...
10
5 Amino Salicylic Acid and Sodium Salicylate Inhibit Activation of IκB Kinase and P38 γ MAP Kinase in LPS Induced RAW 264 7 cell
... The findings from the present study demonstrate the potential of 5-ASA and sodium salicylate as NFκB and P38 MAPK inhibitors in vitro. The results clearly indicate the effect of 5-ASA and sodium salicylate on regulating ...
9
IκB Kinase Subunits α and γ Are Required for Activation of NF-κB and Induction of Apoptosis by Mammalian Reovirus
... ceptors in their so-called T-loop domains (25, 50). Signal- dependent phosphorylation of the T-loop serines in IKK ␣ and IKK  is a prerequisite for their catalytic activation (25). Based on in vitro studies with ...
12
Measles Virus V Protein Is a Decoy Substrate for IκB Kinase α and Prevents Toll-Like Receptor 7/9-Mediated Interferon Induction
... the E3-ubiquitin ligases tumor necrosis factor receptor-associ- ated factor 3 (TRAF3) and TRAF6, and the kinases IL-1 receptor-associated kinase 1 (IRAK1) and IRAK4 (24, 25, 33, 34, 59, 60). Although IRAK1 was ...
9
A Herpesvirus Virulence Factor Inhibits Dendritic Cell Maturation through Protein Phosphatase 1 and IκB Kinase
... binding kinase 1 (TBK1) and interferon (IFN) regulatory factor 3 ...B kinase (IKK), containing the IKK ␣ , ⌱⌲⌲ , and IKK ␥ ...B kinase phosphory- lates I B proteins to trigger their ubiquitination ...
11
Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation
... MCV is specifically adapted to human infection and has a genome predicted to encode 182 proteins, only 105 of which have orthologs in other orthopoxviruses (4). In contrast to non-human-adapted VACV, which causes local ...
16
IκB Kinase ε-Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis
... Tank-binding kinase 1 (TBK1) and IKK , which trigger the antiviral and inflammatory responses via the phosphorylation of transcription factors NF-B and IRF3 (1, 3, ...
12
Hepatitis C Virus Core Protein Suppresses NF-κB Activation and Cyclooxygenase-2 Expression by Direct Interaction with IκB Kinase β
... Primary HCV infection evades protective immunity and es- tablishes a chronic infection (4, 16). Chronic HCV-infected patients have reduced Th1-type CD4 ⫹ T-cell activity and in- creased Th2-type CD4 ⫹ T-cell activity ...
10
Inhibition of IκB Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock
... The activation of NF-κB results in the transcription of a number of proinflam- matory cytokines, chemokines and pro- teins that are widely implicated in the pathophysiology of MOF. Thus, it is not surprising that much ...
13
Efficient Replication by Herpes Simplex Virus Type 1 Involves Activation of the IκB Kinase-IκB-p65 Pathway
... B kinase (IKK) (11, 23, 36, 52, ...a kinase-dead, trans-dominant form of IKK prevents I B phosphorylation and inhibits NF B activation (36, ...nase kinase kinases (MAP3Ks) MEKK1, -2, or -3 or NF ...
9
Beyond NF-κB activation: nuclear functions of IκB kinase α
... NF-κB-inducing kinase (NIK)-dependent p65 TA1 transcriptional activity, suggesting that IKKα phosphorylates the TA1 domain of p65 in the nucleus ...chromatin kinase in the nucleus and targets histone H3 at ...
13
Conditional disruption of IκB kinase 2 fails to prevent obesity induced insulin resistance
... Although the importance of TNF-α in the develop- ment of obesity-associated insulin resistance has been clearly demonstrated over the last decade, the exact molecular mechanisms by which TNF-α induces insulin resistance ...
9
Drosophila Ik2, a member of the IκB kinase family, is required for mRNA localization during oogenesis
... B kinase (IKK) family are known for their roles in innate immune response signaling pathways in both mammals and Drosophila (Ghosh and Karin, 2002; Peters and Maniatis, 2001; Silverman and Maniatis, ...binding ...
9
Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin 1β stimulated fibroblast like synoviocytes
... It has been suggested that taurine chloramine (TauCl) plays an important role in the downregulation of proinflammatory mediators. However, little is known about its effect on the expression of matrix metalloproteinases ...
10
c Fos protein as a target of anti osteoclastogenic action of vitamin D, and synthesis of new analogs
... amounts of protein were loaded for 4–20% SDS-PAGE, and proteins transferred onto the membrane were detected with an ECL Plus West- ern blotting detection system (Amersham Biosciences). Phosphoryla- tion of JNK, p38 MAPK, ...
9
Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer
... protein kinase 1 (TAK1) is a critical mediator in inflammation, immune response and cancer ...p38, IκB kinase (IKK) and c-Jun N-terminal kinase (JNK) and reduced CCR7 expression in metastatic ...
13
Death versus survival: functional interaction between the apoptotic and stress inducible heat shock protein pathways
... Nonstandard abbreviations used: DR, death receptor; FADD, Fas-associated death domain; Hsp, heat shock protein; IAP, inhibitor of apoptosis; IKK, IκB kinase; MOMP, mitochondrial outer me[r] ...
8
IκB-Mediated Inhibition of Virus-Induced Beta Interferon Transcription
... B kinase complex by Sendai virus infection, overexpression of the double-point-mutated (S32A/S36A) dominant repressors of I k B a (TD-I k B a ) completely blocked IFN- b gene activation by Sendai ...
9