IL-1 signaling
Genetic inactivation of IL 1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice
... of IL-1 signaling through genetic deficiency of IL-1R1 in advanced murine ath- erosclerosis results in enhanced features of plaque stability and reduced outward vessel remodeling with ...
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IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation
... that IL-1 signaling mediates accumulation and activation of neutrophils at the maternal-fetal ...interface. IL-1 blockade decreased concentrations of proinflammatory mediators ...
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An Epstein-Barr Virus MicroRNA Blocks Interleukin-1 (IL-1) Signaling by Targeting IL-1 Receptor 1
... ABSTRACT Epstein-Barr virus (EBV) encodes ⬎ 44 viral microRNAs (miRNAs) that are differentially expressed throughout infection, can be detected in Epstein-Barr virus (EBV)-positive tumors, and manipulate several ...
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Inhibiting IL 1 signaling pathways to inhibit catabolic processes in disc degeneration
... Title: Inhibiting IL-1 signalling pathways to inhibit catabolic processes in disc degeneration... Jodie Daniels1, Abbie LA Binch1, Christine L Le Maitre1.[r] ...
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The Role of Interleukin-1 and Interleukin-18 in Pro-Inflammatory and Anti-Viral Responses to Rhinovirus in Primary Bronchial Epithelial Cells
... only IL-1b and IL-18 release was dependent on caspase-1 catalytic ...of IL-1 but not IL-18 signaling inhibited up-regulation of pro-inflammatory mediators and neutrophil ...
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Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma
... the IL-1 pathway in HNSCC cells which limited the efficacy of erlotinib in HNSCC cells ...The IL-1 pathway plays a central role in inflammatory responses by regulating the expression of ...
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Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease
... the IL-1 pathway. At baseline, gene expressions of the IL-1 signaling genes IRAK2, IRAK3, and PELI1 and the signaling receptor IL1R1 were more strongly expressed in the group who ...
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A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis
... and IL-1 receptor ligand, has diverse activities in the ...whether IL-1 signaling contributes to the encephalitis observed in mouse adenovirus type 1 (MAV-1) infection, ...
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A46R and A52R from vaccinia virus are antagonists of host IL 1 and toll like receptor signaling
... antagonizing IL-1 signaling, we examined their ability to inhibit IL-1-induced NFB activation in a reporter gene ...ng兾ml IL-1␣ for 6 h led to a 5-fold stimulation of ...
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Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid
... IL1 signaling leads to deleterious neuroinflammation that either directly dam- ages neurons and/or potentiates the neurotoxic effects of ...IL1 signaling in the AD brain can be detrimental through the ...
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Jones_unc_0153D_17401.pdf
... which IL-1 alters SEFL is another interesting follow up avenue of ...to IL-1β ...that IL-1 signaling was critical to the maintenance, but not the induction of hippocampal LTP ...
119
PubMedCentral-PMC5263184.pdf
... In brief, cells were fixed for 10 min in 4% PFA at RT. Cells were washed with PBS and incubated in PBS-Triton 0.3% for 5 min. After washing they were incubated for 60 min in blocking buffer. Samples were stained ...
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IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells
... and IL-27, in spite of constitutive SOCS3 ex- ...of IL-27 effects, is that the concomi- tant signaling of sIL-6R/IL-6 and IL-27 alters the balance between tyrosine-phosphorylated forms ...
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Association of Src-Related Kinase Lyn with the Interleukin-2 Receptor and Its Role in Maintaining Constitutive Phosphorylation of JAK/STAT in Human T-Cell Leukemia Virus Type 1-Transformed T Cells
... the IL-2R signaling pathway in HTLV-1-infected cell ...including IL-2R, in other cell types ...HTLV- 1-transformed cell lines—HUT102, MT2, MS9, and MS68— contained both IL-2R  ...
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Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation
... cytokine IL-6 are linked to renal fibrosis. However, previously, WT and IL-6 KO mice under UUO showed no significant phenotypic differences [10], probably because the effects of ablating both the ...
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Macrophage derived IL 10 mediates mucosal repair by epithelial WISP 1 signaling
... Since IL-10 promotes WISP-1 synthesis and secretion, we determined whether WISP-1 enhances intestinal epithelial wound repair using the model intestinal epithelial cell lines SKCO-15 and ...with ...
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Characterization of signaling pathways activated by the interleukin 1 (IL 1) receptor homologue T1/ST2 A role for Jun N terminal kinase in IL 4 induction
... type 1 IL-1 re- ceptor and the intracellular domain of T1/ST2 activates NF- B both by overexpression and in response to ...of IL-4 but not IFN- ␥ in naive T ...the IL-1 ...
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IL 6 trans signaling promotes pancreatitis associated lung injury and lethality
... [CNTF], IL-11, and IL-27), IL-6 transmits signals by binding to its mem- brane-bound receptor, IL-6R, and the ubiquitously expressed gp130 ...control IL-6 responses in vivo. IL-6 ...
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Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration
... Mesenchymal stem cells (MSCs) are known to home to injured and inflamed regions through the bloodstream to promote wound healing and tissue regeneration [1]. Much is known about leukocyte and lymphocyte chemo- ...
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Gene variants of interleukin-1 (il-1) and their role in development of osteoarthritis
... as IL-1 that is primarily synthesized by chondrocyte cells (Loughlin et ...2002). IL-1 super family consist of three key classes of interrelated cytokines viz IL-1α, IL-1β, and ...
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