IL-10-deficient mice
Collagen induced arthritis is exacerbated in IL 10 deficient mice
... tor-deficient mice, and loss of the IFN-γ receptor turns mice normally resistant to CIA into an arthritis-susceptible strain ...in IL-10-deficient mice is consistent with ...
7
Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL 10 deficient mice infected with Plasmodium chabaudi
... Mice infected with Plasmodium chabaudi were anes- thetized with inhaled isoflurane (0.25–3 %, to effect) or ketamine/dexmedetomidine cocktail (60–75 mg/ kg K, 0.5–1.0 mg/kg D) i.p. and perfused with 20 mLs PBS via ...
12
Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE
... KO mice are protected from devel- oping EAE as CD73 enables immune cells to enter the CNS ...of IL-10 KO mice suggests these cells are contrib- uting to trying to decrease inflammation in ...
14
PubMedCentral-PMC4913287.pdf
... GF mice with complex faecal microbiota obtained from con- ventionally housed normal ...GF mice have a fully functional immune system, with the capacity to respond rapidly, demonstrated by activation of both ...
11
Inhibition of Histone Deacetylases in Inflammatory Bowel Diseases
... in mice represents an ex- cellent in vivo model to define the specific cell populations and target tissues modulated by inhibitors of ...(IL)- 10–deficient mice and the ...
8
Critical role of the major histocompatibility complex and IL 10 in matrilin 1 induced relapsing polychondritis in mice
... the IL-10- deficient mice with high clinical scores developed high levels of anti-CII ...of IL-10 on immune reactivity to CII needs to be fur- ther ...
8
Interleukin-10 Deficiency Increases Atherosclerosis, Thrombosis, and Low-density Lipoproteins in Apolipoprotein E Knockout Mice
... between IL-10 and IL-12 may play a crucial role in the pathogenesis of atherosclerosis ...(22,23). IL-10, on the other hand, inhibits the secretion of MMPs (24), the synthesis of tissue ...
8
Surface receptor Toso controls B cell–mediated regulation of T cell immunity
... modulates IL-10–competent B cell numbers at sites of inflammation and results in impaired T cell responses upon influ- enza ...on IL-10– competent B cells and their immunosuppressive function ...
18
Prolonged activation of IL-5–producing ILC2 causes pulmonary arterial hypertrophy
... WT mice were purchased from Japan SLC. IL-5/Venus knock-in mice were generated as previously reported ...Rag2-deficient mice (48) were provided by Frederick ...ΔdblGATA mice (49) ...
12
Inhibition of airway remodeling in IL 5–deficient mice
... for IL-5 in mouse models of airway remodeling, using different methods of inducing and assessing it (31, ...a 10-day peri- od to mice sensitized to OVA and demonstrated a ...OVA-challenged ...
11
IL 13Rα2 and IL 10 coordinately suppress airway inflammation, airway hyperreactivity, and fibrosis in mice
... Although IL-10 was identified as the dominant antiinflammatory mediator, studies with double IL-10/IL-13Ra2–deficient mice illustrate an indispensable role for IL- ...
12
B cell regulation of the anti-tumor response and role in carcinogenesis
... cells, IL-10 producing B cells; BCa, bladder cancer; BCDM, B cell deficient mice; Bregs, B regulatory cells; BTK, Bruton ’ s tyrosine kinase; CIA, collagen induced arthritis; CLL, chronic ...
15
Role of IL 12 in Staphylococcus aureus triggered arthritis and sepsis
... Downregulated IL-10 production in the absence of IL-12 could be a reason for the enhanced bac- terial clearance seen in IL-12-deficient mice as compared with controls during the ...
8
IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Rα signaling via T cells
... for IL-4 and IL-4Rα-responsive B cells in the non-healing response of BALB/c mice infected with ...of IL-4R α signaling on B cells in BALB/c mice (mb1 cre IL-4R α −/lox ) turned ...
13
Plasmodium berghei ANKA infection increases Foxp3, IL 10 and IL 2 in CXCL 10 deficient C57BL/6 mice
... CXCL-10-/- mice than WT. Interleukin-2 (IL-2) is a Th1 cytokine produced by activated T lymphocytes and plays a key role in promoting the expansion of antigen-specific T cells and also mediates ...
12
IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation
... of IL-1RA have been shown to correlate with lower risk of worsening asthma con- trol and attacks in adults ...serum IL-1RA may be elevated during acute asthma exacer- bations in a pediatric cohort compared ...
18
Antibody induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis
... KBN mice [121]. Mice depleted of neutrophils using anti-Gr-1 (RB6) antibodies are resistant [126] and neutrophil expression of leukotriene B4 receptor BLT1 was reported to be absolutely required for ...
11
IL 17A and IL 17F do not contribute vitally to autoimmune neuro inflammation in mice
... of IL-17A on CNS inflammation, we generated transgenic mice in which high levels of expression of IL-17A could be initiated after Cre-mediated ...of IL-17A led to skin inflammation and ...
10
Pancreatic islet production of murine interleukin 10 does not inhibit immune mediated tissue destruction
... from IL-10-transgenic donors were rejected with comparable kinetics to the rejection of control nontransgenic allografts, indicating that IL-10 does not inhibit allograft ...infection, ...
8
The role of T cell interleukin 17 in conducting destructive arthritis: lessons from animal models
... with IL-1, which is a key cytokine in the induction of cartilage destruction ...vitro, IL-17 suppresses matrix synthesis by articular chondrocytes through enhancement of nitric oxide production ...of ...
9