IL-16
Structure of a potential therapeutic antibody bound to Interleukin-16 (IL-16): mechanistic insights and new therapeutic opportunities
... Structure-based Design of Small Molecules to Target the IL-16 Functional Site Recognized by c14.1Fab—The innovative use of antibodies and antibody fragments to identify opportunities for small molecule drug ...
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Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions
... of IL-16 precursor (pro-IL-16, 80 kD), and mature, secreted IL-16 (22 kD), compared to normal control brain and spinal cord white matter ...pro- IL-16 did not ...
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IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation
... identify IL-16, a proinflammatory cytokine known to drive airway inflammation (36– 42), as a novel and direct target of ...Importantly IL-16 levels are increased in SLE patients and associate ...
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Loss of nuclear pro–IL 16 facilitates cell cycle progression in human cutaneous T cell lymphoma
... ing IL-2, IL-7, IL-15, IL-16, and IL-18 (8–14), although not all have demonstrated growth potential in CTCL cell lines or primary T cells from patients with ...
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IL-14 and IL-16 are expressed in the thyroid of patients with either Graves' disease or Hashimoto's thyroiditis
... GD, IL-14 may be directly involved in initiation and/or progression of the autoimmune ...contrast, IL-16 is involved in cellular immune responses 13,14 and is produced by several cell types including ...
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Original Article Interleukin-16 gene polymorphism is associated with acute coronary syndrome in the Chinese Han population
... and 200 μM primers) and used for PCR amplifi- cation followed preliminary denaturation at 94°C for 2 min, followed by 35 cycles of 94°C for 30 s, annealing temperature reduced to 64°C for 30 s, and 72°C for 10 min by ...
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Original Article Role of gene polymorphisms and plasma levels of interleukin-16 in susceptibility to papillary thyroid carcinoma
... in IL-16 and risk of PTC were investigated in a Chinese ...in IL-16 was found to be associat- ed with an increased risk of PTC in genotype and allele ...increased IL-16 ...
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Serum cytokine profiling and enrichment analysis reveal the involvement of immunological and inflammatory pathways in stable patients with chronic obstructive pulmonary disease
... (IL-6), IL-16, and stem cell factor are signifi- cantly higher in COPD patients compared with in control ...eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory ...
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Interleukin-16-producing NK cells and T-cells in the blood of tobacco smokers with and without COPD
... smokers (COPD + AS), a finding that seems to be related to smoking irrespectively of COPD. In line with this observation in long-term smokers who are also current smokers, we found a clear, negative correlation between ...
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Changes in serum cytokines in response to musculoskeletal surgical trauma
... proinflammatory IL-1β, IL6 and TNF-α and modulates apoptosis ...plasma IL-16 levels was transiently increased as compared with non-injured controls ...that IL-16 may be a component of ...
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Original Article Genetic polymorphism of interleukin-16 rs11556218 T/G influences susceptibility to breast cancer in a Chinese population
... mples (96.5% of total samples) or exfoliated buccal cells (3.5% of total samples) as previ- ously described [11]. For quality control, geno- typing was repeated randomly in at least 5% of the samples, and two of the ...
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Cloning bovine cytokine cDNA fragments and measuring bovine cytokine mRNA using the reverse transcription polymerase chain reaction
... RESULTS Amplification and Cloning of Bovine cDNA Fragments for IL-la, IL-16, IL-2, and IFN-y Our strategy for cloning nucleic acid probes for bovine IL-la, IL-lB, IL-2, and IFN-y involve[r] ...
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Original Article Expression of IL-2, IL-6, IL-10, and IL-1β in rats with fungal keratitis
... (IL-2), IL-6, IL-10, and IL-1β in rats with fungal ...of IL-2, IL-6, IL-10, and IL-1β in corneal epithelial tissues were detected via immunohistochemistry at 24 ...
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Comparison of paired human nasal and bronchial airway epithelial cell responses to rhinovirus infection and IL-13 treatment
... In the current study, we aimed to use paired nasal and bronchial cells cultured in both submerged and ALI con- ditions to determine whether cells from nasal brushings can be representative of those from bronchial brush- ...
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Evaluation of serum levels of IL 17, IL 20 AND IL 22 IN psoriatic patients from north india and their correlation with disease severity
... of IL-17, Il-20 and IL-22 in psoriasis. IL-17, IL-20 and IL-22 stands as the therapeutic target in psoriasis and several new drugs should be explored which inhibit IL-17, ...
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The IL 23/IL 17 axis in inflammation
... (Th17/Th IL-17 ) that produce IL-17, IL-17F, IL-6, and TNF-a, but not IFN-g and ...blocking IL-23 or its downstream factors IL- 17 and IL-6, but not the IL-12/IFN-g ...
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Inhibition of IL 12 production by 1,25 dihydroxyvitamin D3 Involvement of NF kappaB downregulation in transcriptional repression of the p40 gene
... IL-12 is a heterodimeric cytokine composed of two disul- fide linked subunits of 35 (p35) and 40 (p40) kD encoded by two separate genes (7–9). Inducible expression of IL-12 has been documented in ...
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Escherichia coli and Staphylococcus aureus Elicit Differential Innate Immune Responses following Intramammary Infection
... anti-ovine IL-1 (5 g/ml) antibody (Serotec, ...ovine IL-1 (a gift from CSIRO Livestock Industries, Victoria, Australia) were assayed in ...ovine IL-1 polyclonal serum (Serotec) was diluted ...
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corsolabview pdf
... premuto il tasto sinistro e trascinare verso il basso, fi no a quan- do gli ingressi del blocco non diventano ...corretta, il collegamento va fat- to in base al nome del controllo, quindi il ...
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Immunosuppressant FK506 induces interleukin 6 production through the activation of transcription factor nuclear factor (NF) kappa(B) Implications for FK506 nephropathy
... the IL-6 gene (9). In particular, NF-kB activation is essen- tial for IL-6 gene expression as shown in in vitro (23) and in vivo knockout mice (38) ...induces IL-6 production in mesangial cells (Fig. ...
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