IL-2
Lipoteichoic Acid Inhibits Interleukin-2 (IL-2) Function by Direct Binding to IL-2
... which IL-2 mRNA levels were evaluated did not support this hypothesis (data not ...with IL-2 detection and ...to IL-2. This MAb binds to the IL-2R binding site on ...
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IL 2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients
... bolus IL-2 therapy is currently one of the most potent forms of immunotherapy and was approved by the FDA as a single-agent cytokine therapy for metastatic melanoma and renal cell carcinoma ...HD ...
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IFN γ and Fas/FasL are required for the antitumor and antiangiogenic effects of IL 12/pulse IL 2 therapy
... therapy. IL-12 is an important immunoregulatory cytokine that enhances several functions of T and/or NK cells (1) and possesses potent IFN- γ –dependent therapeutic activity in various murine tumor models ...
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Original Article Correlation of IL-10 and IL-2 single gene polymorphisms with the susceptibility to pigeon breeder’s lung in Chinese Uygur population
... and IL-2 gene single nucleotide polymor- phisms (SNP) with the susceptibility to pigeon breeder’s lung (PBL) in Chinese Uygur ...of IL-10 and 4 SNPs of IL-2 were ...16 IL-10 SNPs ...
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The contrasting roles of IL 2 and IL 15 in the life and death of lymphocytes: implications for the immunotherapy of rheumatological diseases
... the IL-2/IL-2R or IL-15/IL-15R systems have focused on the alpha subunit of the IL-2 ...toward IL-2Rα have met with considerable success in the treatment of ...
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Original Article Changing trend and significance of serum IL-2 and IL-4 levels in rats with nephrotic syndrome
... that IL-2 ex- pression in serum of NS rats was lower com- pared to that of sham-operated rats, whereas expression of IL-4 was increased in the serum of NS ...rats. IL-2 is mainly ...
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Relationship between Cysteine, Interleukin (IL)-2, And Interleukin (IL)-10 in Children with Marasmus Type Malnutrition
... the IL-2 level was signifi- cantly lower in patients with malnutrition compared to the control group and the IL-10 level was considerably higher in marasmus patients compared to control ...type ...
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PP2A enables IL-2 signaling by preserving IL-2Rβ chain expression during Treg development
... the IL-2Rβ chain, which occurs upon binding of IL-2, could not account for its decreased expression on the surface membrane of PP2A-deficient ...the IL-2Rβ chain is quickly internalized in ...
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Proinflammatory Cytokines IL 2, IL 6 and TNF Alpha as Immunoseralogic Indicators of Chronic Viral Hepatitis B and C in Children
... The study was conducted on 181 children with chronic viral hepatitis B (in 107 cases) and C (in 84 cases), ages 3 to18 years [Table 1]. In order to determine the particularities of the cellular immunity in 50 children ...
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A retrospective analysis of High-Dose Interleukin-2 (HD IL-2) following Ipilimumab in metastatic melanoma
... HD IL-2 toxicity that was considered possibly related to prior ...completing IL-2 ...HD IL-2 which was resistant to high dose steroid administra- ...HD IL-2 ...
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Systemic lupus erythematosus serum IgG increases CREM binding to the IL 2 promoter and suppresses IL 2 production through CaMKIV
... induce the expression of CREM in normal T cells. As shown in Figure 3A, treatment of normal T cells with SLE sera increased the levels of CREM mRNA (Figure 3B, n = 10, P < 0.05). Treatment of normal T cells with SLE ...
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IL 2 immunotherapy in chronically SIV infected Rhesus Macaques
... human IL-2 (Macrolin W Aldesleukine rhIL-2) or saline solution (control) daily for 5 ...before IL-2 treat- ment (day 0) and at day 7, 10, 15, 30 and 45 after ...
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Epitope specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL 2 and IL 15 in vitro
... to IL-2 and IL-15, treatment of the tolerized T cells with IL-4 re-established the allergen induced Th2 cytokine production only at lower ...observed, IL-4 treatment of tolerized cells ...
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Original Article Tulobuterol path transdermal drug delivery reduces serum level of ICAM 1, VCAM 1, IL-2, IL-6, IL-8, and IL-10 in children with bronchial asthma
... 1, IL-2, IL-6, IL-8, IL-10 and the occur- rence and development of children with bron- chial ...1, IL-2, IL-6, IL-8, and ...
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Plasmodium berghei ANKA infection increases Foxp3, IL 10 and IL 2 in CXCL 10 deficient C57BL/6 mice
... cytes. IL-2 mediates signaling through IL-2Ra, and regu- lates Foxp3 expression in CD4+CD25+Foxp3+ ...by IL-2 [34]. The results showed that at days 2 and 4, IL-2 ...
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Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats
... modulates IL- 2 and IL-4 expression in skeletal ...in IL-4 and MyoD protein expression observed in the EDL may be related to increased activation and prolif- eration in stem cells after ...
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Assessment of Serum IL-2 and Immunohistochemistry Detection of IL-2 in Induced Hypothyroidism of Male Rats
... of IL-2 of the fourth group when compared with the first group , while the results revealed a significant increase when compared with the second group ,whereas a significance decrease when compared with the ...
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Cellular expression of interleukin 2 (IL-2) and its receptor (IL-2R, CD25) in lung tumours
... TNF, IL-1) by monocytes and macrophages [18, 19, ...with IL-2 remain far from ...of IL-2 by im- munocompetent cells isolated from the blood of tu- mour-bearing ...of IL-2 ...
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Novel interleukin 2 (IL 2) receptor appears to mediate IL 2 induced activation of natural killer cells
... recombinant IL-2 to the enriched NK cells promoted a rapid augmentation of cytolytic activity and a more delayed increase in cellular ...the IL-2-induced proliferative response in these cells, ...
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Altered regulation of IL 2 production in systemic lupus erythematosus: an evolving paradigm
... hinder IL-2 gene transcrip- tion and IL-2 production and contribute to impaired T cell effector functions in SLE ...of IL-2 ...
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