IL-6/JAK2/STAT3 pathway
A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/ Jak2/Stat3 pathway
... of Stat3 (Y705) in chronic myeloid leukemia and multiple myeloma [32, ...and Stat3’s role in Icaritin-mediated HCICs inhibition have not been investigated ...targeted IL-6Rs, attenuated both ...
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The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells
... 25]. IL-6 is a mul- tifunctional cytokine, and its dysfunction and abnor- mal expression often lead to disease [26, ...serum IL-6 levels were significantly increased in CRC patients and that ...
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Induction of metastatic potential by TrkB via activation of IL6/ JAK2/STAT3 and PI3K/AKT signaling in breast cancer
... signal pathway-mediated tumor metastasis and EMT ...of JAK2/STAT3 by inducing c-Src- JAK2 complex ...to JAK2 and inhibits SOCS3-mediated JAK2 degradation, resulting in increased ...
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The Influence of Gastrodin on Expression of IL 10, STAT3 and JAK2 in Epileptic Rats’ Hippocampus
... of JAK2/STAT3 target, our experimental results show that the JAK2 and STAT3 expression in EP Group is significantly higher than that in NC group, and the JAK2 and STAT3 positive ...
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Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251
... of STAT3 inactivation, the activation of the JAK2-STAT3 pathway was ...or IL-6 family cytokines, JAK2 proteins bind receptors and trans- or auto-phosphory- late themselves ...
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Original Article IL-9 promotes proliferation and metastasis of hepatocellular cancer cells by activating JAK2/STAT3 pathway
... (JAK/STAT3) pathway is involved in the patho- genesis of different types of solid tumor [4, ...JAKs, STAT3 translocate to nucleus and induce expression of down- stream molecules, such as vascular ...
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<p>Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation</p>
... on STAT3 activation, we stimulated esophageal carcinoma cells with IL-6 to detect the effect of CTS on the STAT3 signaling ...of IL-6 (25 ng/mL) for 30 minutes could effectively ...
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Bacterial Lipopolysaccharide Vigorously Activate JAK2/STAT3 Induced Rheumatoid Arthritis Collate with Complete Freund's Adjuvant in Experimental Rats
... on JAK2/STAT3-induced RA, compared to the traditional Complete Freund’s Adjuvant (CFA)-induced ...phosphorylated JAK2 and STAT3, while serum samples used for biochemical evaluation of ...
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The JAK2 pathway is activated in idiopathic pulmonary fibrosis
... or IL-6/IL-13 as an enhancer of epithelial to mesenchymal transition, as both increased collagen type I and E-cadherin gene mRNA expression ...siRNA- JAK2 or siRNA-STAT3, and completely ...
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Regulatory effect of calcineurin inhibitor, tacrolimus, on IL 6/sIL 6R mediated RANKL expression through JAK2 STAT3 SOCS3 signaling pathway in fibroblast like synoviocytes
... of STAT3 in cell survival, growth, and differentiation [7], STAT3 is closely related to osteoclasto- genesis ...the IL-6/sIL-6R complex, requires activation of STAT3 ...of STAT3 ...
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Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/ STAT3
... suppressing JAK2/STAT3 signaling pathway, not associated with estrogen ...with STAT3-directed siRNA and non-specific siRNA (control), the success of STAT3 silencing was confirmed by ...
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Original Article MicroRNA-30b targets CBX3 and regulates cell proliferation, apoptosis, and migration in esophageal squamous cell carcinoma via the JAK2/STAT3 signaling pathway
... the JAK2/STAT3 signaling pathway was investigat- ...the JAK2/STAT3 signaling pathway widely occurs with high frequency in ESCC and disruption of this pathway can repress ...
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Associations of potentially functional variants in IL-6 JAKs and STAT3 with gastric cancer risk in an eastern Chinese population
... JAK1, JAK2, and STAT3 are considered the essential components of the IL-6/JAK/STAT3 signaling pathway involved in promoting tumorigenesis [11], and these genes were observed to ...
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Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
... Macroautophagy (hereafter referred to as autophagy) is an evolutionarily ancient and highly conserved cata- bolic process that transports cellular proteins and organ- elles to facilitate lysosomal degradation ...
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Original Article Downregulation of HSF2 inhibits inflammation in human intestinal epithelial cells by regulating IL-6/STAT3 signaling pathway
... as IL-1 and IL-6, and decreased secretion of anti-inflammatory factor IL-10, cause the development of inflam- mation, which stimulates leukocytes in the blood circulation to move and ...
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IL 17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis
... between IL-17 and disease markers including ESR, CRP, and BASDAI were varied as shown in Additional file 1: Figures S2 and S3 (ESR: r = − ...that IL- 17 contributes to osteogenesis and bone formation [32, ...
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Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats
... administration causes aberrations in the expression of genes involved in the oxidative stress pathway, resulting in DNA damage and hepatotoxicity. Rutin protects against this by enhancing antioxidant genes [29]. ...
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Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop
... and resistance to chemotherapy or radiotherapy. Several previous studies demonstrated that CD44-positive gastric cancer cells possessed the features of CSC. In severe combined immunodeficiency mice, CD44-positive gastric ...
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A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells
... For IL-6 and IFN-γ stimulation experiments, DLD1 and Hep3B cells were serum-starved for 12 hours and pretreated with LY5 ...ng/ml IL-6 or IFN-γ was added, and the cells were harvested 30 ...
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IRE1α XBP1 pathway promotes melanoma progression by regulating IL 6/STAT3 signaling
... nology), STAT3 (1:1000, Cell Signaling Technology) or GAPDH (1:5000, Abcam, Cambridge, UK) overnight at 4 °C, and this was followed by incubation with horserad- ish peroxidase-conjugated secondary ...
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