IL-7
Human articular chondrocytes produce IL 7 and respond to IL 7 with increased production of matrix metalloproteinase 13
... whether IL-7-mediated PYK2 phosphor- ylation was associated with production of matrix-degrading enzymes, as we had previously shown using fibronectin frag- ment ...of IL-7 for further ...
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Recombinant IL 7/HGFβ efficiently induces transplantable murine hematopoietic stem cells
... of IL-7 and other cytokines is reduced in the irradiated BM (27–29), it was possible that the ability of the culture-generated HSCs to home to, implant in, and/or repopu- late the host BM is ...
12
Increased production of IL 7 uncouples bone formation from bone resorption during estrogen deficiency
... that IL-7 is one such factor adds to the ongoing controver- sy regarding the relevance in vivo of the regulatory effects of each of the presently known E2-regulated fac- ...are IL-1 (38, 39), ...
9
IL-7–dependent STAT1 activation limits homeostatic CD4+ T cell expansion
... addition, IL-7 signaling activates the PI3K/AKT pathway, which constitutes a critical signal for survival and proliferation ...Whether IL-7–dependent STAT1 activation regulates AKT pathway ...
19
Stimulation of Bovine Whole Blood Samples Cultured in Media Supplemented with Recombinant Interleukin 7 (IL 7) and IL 12 Extends the Life Span of the Gamma Interferon Assay To Detect Mycobacterium bovis Infected Cattle
... In preliminary investigations, to determine the specificity of the IFN- ␥ response after tuberculin stimulation with bovine purified protein deriv- ative (PPDB) (M. bovis) and avian purified protein derivative (PPDAv) ...
6
IL 7 is a potent and proviral strain–specific inducer of latent HIV 1 cellular reservoirs of infected individuals on virally suppressive HAART
... that IL-7, at 6 hours after addi- tion, induced HIV-1 LTR activity by only 2-fold at a concentration of 100 ng/ml, while at lower concentrations ...ng/ml), IL-7 demonstrated no effect. ...
11
HIV infection of thymocytes inhibits IL 7 activity without altering CD127 expression
... the IL-7 pathway that occurs independent of its effect on CD127 ...reduced IL-7 responsiveness in CD127-expressing CD8 + T-cells from HIV + ...following IL-7 stimulation when ...
6
LNK/SH2B3 regulates IL 7 receptor signaling in normal and malignant B progenitors
... vation of AKT, S6, and pERK (Figure 9A), in addition to elevated basal pSTAT5 levels, although IL-7 did not induce pAKT, pS6, or pERK activation in freshly isolated B progenitors in our assay. This result ...
16
Immunomodulatory and anticancer potential of Gan cao (Glycyrrhiza uralensis Fisch ) polysaccharides by CT 26 colon carcinoma cell growth inhibition and cytokine IL 7 upregulation in vitro
... vivo, IL-7 is responsible for development, maturation, proliferation and homeostasis of T lymphocytes [58, ...secreted IL-7, though to a slight extend, enhanced proliferation of ...that, ...
8
Adjuvant IL 7 or IL 15 overcomes immunodominance and improves survival of the CD8+ memory cell pool
... If IL-7–mediated costimulation renders subthreshold peptide- TCR interactions sufficient for cells to undergo a proliferative burst, and if rhIL-15 enhances the size of the proliferative burst, one would ...
12
Increase of plasma IL 9 and decrease of plasma IL 5, IL 7, and IFN γ in patients with chronic heart failure
... in IL-9 levels in both ICM and NIDCM groups vs controls and that IL-9 levels inversely correlated with ejection fraction in ICM patients, but not in NIDCM ...of IL-7 in both ICM and NIDCM CHF ...
7
Dual Mechanism of Impairment of Interleukin-7 (IL-7) Responses in Human Immunodeficiency Virus Infection: Decreased IL-7 Binding and Abnormal Activation of the JAK/STAT5 Pathway
... of IL-7 to memory CD4 T cells of viremic ...whether IL-7 binding to patient CD4 ⫹ T cells would increase or ...assess IL-7 binding, using flow cytometry detection of biotinylated ...
13
IL 7 inhibits fibroblast TGF β production and signaling in pulmonary fibrosis
... production, IL-7 was found to potently induce Smad7 and subsequently block TGF- β ...Although IL-7 is known to induce IFN- γ , our current study indicates that IL-7 mediates ...
8
Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes
... microenvironment. IL-7 and IL-15, the members of common gamma-chain family cytokine, are essential for establishment of maintenance of normal immune system ...13], IL-15 plays an important ...
10
Elevated levels of circulating IL 7 and IL 15 in patients with early stage prostate cancer
... promoting IL-6, IL-7 and IL-15 gene expression and protein production in PCA is also ...including IL-6, have repeatedly been suggested to pro- mote prostate ...
9
Study of T Cell subsets and IL-7 protein expression in HIV-1-infected patients after 7 years HAART
... of Il-7 may be due to an incom- plete recovery of the Il-7/Cd127 regulation mecha- nisms after seven years of ...whereas Il-7- induced mitosis of transitional memory t cells can ...
7
Original Article Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells
... human IL-7 (20 ng/ml) for 24 h; siIL-7R+IL-7 group: cells transfected with IL-7R siRNA then incubated with recombinant human IL-7 (20 ng/ml) for 24 h; siIL-7R group: cells ...
12
Estrogen deficiency and bone loss: an inflammatory tale
... IL-7 has been reported to induce production of RANKL by human T cells 74, and injection of IL-7 into mice in vivo induces bone destruction by inducing T cell production of RANKL and TNF [r] ...
10
Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy
... increased IL-7 level in serum and IL-2 and IL-7 levels in CSF ...of IL-2 in CSF and not in serum in NB patients reflects a general T cell activation in the CNS ...
6
Interleukin 7 deficiency in rheumatoid arthritis: consequences for therapy induced lymphopenia
... RA. IL-7 deficiency may again be relevant. IL-7 is pro- duced in response to lymphopenia [7] and stimulates proliferation of both naïve and memory human ...of IL-7 in ...
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